Click here to switch to the map view.

The map label for this gene is tig

Identifier: 110634141

GI number: 110634141

Start: 1914636

End: 1916066

Strand: Reverse

Name: tig

Synonym: Meso_1790

Alternate gene names: 110634141

Gene position: 1916066-1914636 (Counterclockwise)

Preceding gene: 110634144

Following gene: 110634137

Centisome position: 43.42

GC content: 60.59

Gene sequence:

>1431_bases
ATGCAGGTTAGCGAGATTCTCAACTCCGGTCTTAAGCGCGAGATCAAGATCACCGTGCCGGCCGAGGACATGGAAGCCCG
CCTCATGGCGCGCCTGGAAGATGCCAAGAACAAGGTGCGGCTGAAGGGCTTCCGGCCTGGCAAGGTGCCGTTGCAGCACC
TGCGCCGCATGTACGGCAAGTCCTTCATGGCCGAGGTCGTGAACGAGATCCTCAACGATTCCTCGCGCACCATCATCTCC
GACCGCGGTGAAAAGCCTGCGATGCAGCCGGAAATCTCCATGACGGAGGACGAGAAGGAAGCCGAGAAGGTGCTCGCCGG
CGCGGCTGATTTCGAATTCTCGCTTTCCTACGAGGTGATCCCGCCGATCGAAATCAAGGATCTCGCCGGTATAAAGATCA
CGCGTCCGGTCTATGACGTGCCGGACGAGGAGGTGGACGAGCAGGTGAAGCGCGTTGCCGACTCCGTCCGCACCTATGAG
GCGAAGAAGGGAAAAGCCGAGAAGGGCGACAAGGTCACCCTCGATTATGTCGGCAAGCTTGACGGCGAGCCATTCGACGG
GGGCTCAGCCAACGACTCGGAAGTCGTGATCGGCCACGGCCAGTTCATCCCGGGCTTCGAGGACGAGTTGATCGGCCTCA
AGGCTGGCGACACGAAAACCTTCAAGATCACATTCCCGGAAACCTACGGGGCTCAGCATCTGGCTGGCAAGGAAGCTGAA
TTCGACGTCACCGTGAAAGAGGTGGCCGCGGCCGAGGAACTGGTGATCGACGACGAACTGGCCAAGAAGCTTGGGCTCGA
GTCGGCAGAGAAGCTGCGCGAGATCATCCGCAGCCAGCTCGAGAACCAGTACGGCCAGATGACCCGCCAGAAGGCCAAGC
GCCAGCTGCTCGACGCGTTGGACGAGAGTTACAAGTTCGAGGCGCCCTCCAAGCTGGTCGAGGCGGAGTTCAACAATATT
TGGTCGCAGGTTACGCGCGACCTTGAGTCTGCCGGCCGTACTTTCGAAGACGAAGAGACGACCGAGGACGACGCGCGTCA
GGAATATCAGCGCCTTGCCGAACGCCGTGTTCGCCTGGGCCTGGTGCTCGCGCAGATCGGCGAAGAGGCCAGTATTCAGG
TTTCCGACGACGAGATGCAGCGGGCGCTCATCGAGACGATCCGCCGCTATCCCGCCCAGCAACAGCAGGAGATCTACGAC
TTCTATCGCCAGAACCCGCAAGCGCTGGCGTCGGTACGCGCTCCGCTCTTCGAGGAGAAGGTGGTCGATCAATTGCTTTC
GCAGGTCGATGTGACCGACCAGAAGGTCAGCCGCGACGAACTCCTGGCCGAGGATGAGGCCGAGGGGGAAGAAAAGAAGG
CTGCGGGCGAGACCAAGAAGAAGGCGGCACCTAAGAAGAAGGCCGCCAAGAAGGAAAGCGCCGCAGAATAG

Upstream 100 bases:

>100_bases
CCCTCCACCCGCACCAGGCCACCCCTGGACACGGATTTTCGGCAGGCTGGCGGCGGGTGCCGCGGAGCCGCTGGCACGAA
TGAACATAAAGGTTTGATGA

Downstream 100 bases:

>100_bases
GCGTTTGCGAAAAACCAAAAAACCCCGGTTCGCCCCGGGGTTTTTTATTTCACGATTTTCAAGTCATGCCGGCTGCGCCT
TCAGGCGCGGCAGCGGCGGG

Product: trigger factor

Products: peptidylproline (w =0) [C]

Alternate protein names: TF

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MQVSEILNSGLKREIKITVPAEDMEARLMARLEDAKNKVRLKGFRPGKVPLQHLRRMYGKSFMAEVVNEILNDSSRTIIS
DRGEKPAMQPEISMTEDEKEAEKVLAGAADFEFSLSYEVIPPIEIKDLAGIKITRPVYDVPDEEVDEQVKRVADSVRTYE
AKKGKAEKGDKVTLDYVGKLDGEPFDGGSANDSEVVIGHGQFIPGFEDELIGLKAGDTKTFKITFPETYGAQHLAGKEAE
FDVTVKEVAAAEELVIDDELAKKLGLESAEKLREIIRSQLENQYGQMTRQKAKRQLLDALDESYKFEAPSKLVEAEFNNI
WSQVTRDLESAGRTFEDEETTEDDARQEYQRLAERRVRLGLVLAQIGEEASIQVSDDEMQRALIETIRRYPAQQQQEIYD
FYRQNPQALASVRAPLFEEKVVDQLLSQVDVTDQKVSRDELLAEDEAEGEEKKAAGETKKKAAPKKKAAKKESAAE

Sequences:

>Translated_476_residues
MQVSEILNSGLKREIKITVPAEDMEARLMARLEDAKNKVRLKGFRPGKVPLQHLRRMYGKSFMAEVVNEILNDSSRTIIS
DRGEKPAMQPEISMTEDEKEAEKVLAGAADFEFSLSYEVIPPIEIKDLAGIKITRPVYDVPDEEVDEQVKRVADSVRTYE
AKKGKAEKGDKVTLDYVGKLDGEPFDGGSANDSEVVIGHGQFIPGFEDELIGLKAGDTKTFKITFPETYGAQHLAGKEAE
FDVTVKEVAAAEELVIDDELAKKLGLESAEKLREIIRSQLENQYGQMTRQKAKRQLLDALDESYKFEAPSKLVEAEFNNI
WSQVTRDLESAGRTFEDEETTEDDARQEYQRLAERRVRLGLVLAQIGEEASIQVSDDEMQRALIETIRRYPAQQQQEIYD
FYRQNPQALASVRAPLFEEKVVDQLLSQVDVTDQKVSRDELLAEDEAEGEEKKAAGETKKKAAPKKKAAKKESAAE
>Mature_476_residues
MQVSEILNSGLKREIKITVPAEDMEARLMARLEDAKNKVRLKGFRPGKVPLQHLRRMYGKSFMAEVVNEILNDSSRTIIS
DRGEKPAMQPEISMTEDEKEAEKVLAGAADFEFSLSYEVIPPIEIKDLAGIKITRPVYDVPDEEVDEQVKRVADSVRTYE
AKKGKAEKGDKVTLDYVGKLDGEPFDGGSANDSEVVIGHGQFIPGFEDELIGLKAGDTKTFKITFPETYGAQHLAGKEAE
FDVTVKEVAAAEELVIDDELAKKLGLESAEKLREIIRSQLENQYGQMTRQKAKRQLLDALDESYKFEAPSKLVEAEFNNI
WSQVTRDLESAGRTFEDEETTEDDARQEYQRLAERRVRLGLVLAQIGEEASIQVSDDEMQRALIETIRRYPAQQQQEIYD
FYRQNPQALASVRAPLFEEKVVDQLLSQVDVTDQKVSRDELLAEDEAEGEEKKAAGETKKKAAPKKKAAKKESAAE

Specific function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation

COG id: COG0544

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain

Homologues:

Organism=Escherichia coli, GI1786640, Length=444, Percent_Identity=30.6306306306306, Blast_Score=216, Evalue=3e-57,

Paralogues:

None

Copy number: 1070 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 500 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 340 Molecules/Cell In: Growth-Phase, Mini

Swissprot (AC and ID): TIG_MESSB (Q11HE1)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674349.1
- ProteinModelPortal:   Q11HE1
- SMR:   Q11HE1
- STRING:   Q11HE1
- GeneID:   4182760
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1790
- NMPDR:   fig|266779.1.peg.3731
- eggNOG:   COG0544
- HOGENOM:   HBG635105
- OMA:   RFIPGFE
- PhylomeDB:   Q11HE1
- ProtClustDB:   PRK01490
- BioCyc:   MSP266779:MESO_1790-MONOMER
- HAMAP:   MF_00303
- InterPro:   IPR001179
- InterPro:   IPR005215
- InterPro:   IPR008880
- InterPro:   IPR008881
- Gene3D:   G3DSA:1.10.3120.10
- Gene3D:   G3DSA:3.30.70.1050
- PANTHER:   PTHR10516
- PIRSF:   PIRSF003095
- TIGRFAMs:   TIGR00115

Pfam domain/function: PF00254 FKBP_C; PF05698 Trigger_C; PF05697 Trigger_N; SSF109998 Trigger_fac_C_bac; SSF102735 Trigger_fac_ribosome-bd_bac

EC number: NA

Molecular weight: Translated: 53539; Mature: 53539

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVSEILNSGLKREIKITVPAEDMEARLMARLEDAKNKVRLKGFRPGKVPLQHLRRMYGK
CCHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHH
SFMAEVVNEILNDSSRTIISDRGEKPAMQPEISMTEDEKEAEKVLAGAADFEFSLSYEVI
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEC
PPIEIKDLAGIKITRPVYDVPDEEVDEQVKRVADSVRTYEAKKGKAEKGDKVTLDYVGKL
CCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCC
DGEPFDGGSANDSEVVIGHGQFIPGFEDELIGLKAGDTKTFKITFPETYGAQHLAGKEAE
CCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHCCCCCC
FDVTVKEVAAAEELVIDDELAKKLGLESAEKLREIIRSQLENQYGQMTRQKAKRQLLDAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DESYKFEAPSKLVEAEFNNIWSQVTRDLESAGRTFEDEETTEDDARQEYQRLAERRVRLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LVLAQIGEEASIQVSDDEMQRALIETIRRYPAQQQQEIYDFYRQNPQALASVRAPLFEEK
HHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VVDQLLSQVDVTDQKVSRDELLAEDEAEGEEKKAAGETKKKAAPKKKAAKKESAAE
HHHHHHHHCCCCHHHHCHHHHHHCCCCCCHHHHHCCCHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQVSEILNSGLKREIKITVPAEDMEARLMARLEDAKNKVRLKGFRPGKVPLQHLRRMYGK
CCHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHH
SFMAEVVNEILNDSSRTIISDRGEKPAMQPEISMTEDEKEAEKVLAGAADFEFSLSYEVI
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEC
PPIEIKDLAGIKITRPVYDVPDEEVDEQVKRVADSVRTYEAKKGKAEKGDKVTLDYVGKL
CCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHCC
DGEPFDGGSANDSEVVIGHGQFIPGFEDELIGLKAGDTKTFKITFPETYGAQHLAGKEAE
CCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHCCCCCC
FDVTVKEVAAAEELVIDDELAKKLGLESAEKLREIIRSQLENQYGQMTRQKAKRQLLDAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DESYKFEAPSKLVEAEFNNIWSQVTRDLESAGRTFEDEETTEDDARQEYQRLAERRVRLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LVLAQIGEEASIQVSDDEMQRALIETIRRYPAQQQQEIYDFYRQNPQALASVRAPLFEEK
HHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VVDQLLSQVDVTDQKVSRDELLAEDEAEGEEKKAAGETKKKAAPKKKAAKKESAAE
HHHHHHHHCCCCHHHHCHHHHHHCCCCCCHHHHHCCCHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: peptidylproline (w =180) [C]

Specific reaction: peptidylproline (w =180) = peptidylproline (w =0) [C]

General reaction: Isomerases; cis-trans-Isomerases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA