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The map label for this gene is gmk

Identifier: 110634114

GI number: 110634114

Start: 1885199

End: 1885855

Strand: Reverse

Name: gmk

Synonym: Meso_1763

Alternate gene names: 110634114

Gene position: 1885855-1885199 (Counterclockwise)

Preceding gene: 110634115

Following gene: 110634107

Centisome position: 42.74

GC content: 62.56

Gene sequence:

>657_bases
ATGGAATCCGCCTCGCCATCCGCCACGATCCGCCGCAGGGGAGTGATGCTGGTTCTCTCCTCGCCTTCGGGTGCCGGCAA
ATCGACCATTGCAAGGAGTCTGCTCGAGAACGATCACGAATTCGAGCTGTCGGTGAGTGTCACCACGCGCCCGCGCCGCC
CCAGCGAGATCGAGGGTGTGCATTATCATTTCAAGACGCAGCGCGATTTTGAGATGATGCGTGATGGCGGCGATCTGCTC
GAATGGGCCGAGGTGCATGGCAACTGCTACGGCACGCCCCGCGGCCCAGTCGAACGGGCGATCGCGGGTGGACGCGACAT
GCTCTTCGACATCGACTGGCAGGGGGCCGCGCAGTTGCGCGAAAAGATGCCGGACGATATCGTCTCCGTCTTCATCCTGC
CGCCGACCATGAAGGAATTGCTGGCGCGCCTCACAAGGCGGGCGGAGGATACGCCCGAGATCATTGAGCGGCGCCTAAGG
AACGCCCATCACGAGATCGAGCAGTGGCGAGACTACGATTATGTCGTCATAAACGACGATCTGGACCGCGCCTTTGCATC
CGTCCGCGCGATCGTGTCGGCGGAGCGTCTACGGCACGAGCGGCGGCCGGGACTTGAGGATTTCGTGGCGGGGCTTTTGG
CGGAGAGACCGGAATAG

Upstream 100 bases:

>100_bases
TCTGCTCCAAGTCAAACGCCTCTTCCGTCACGGCGATCGGCCTTGAATTGAAGGCTGTCGTCGATCAGTTTCGGGAGCAG
GTGCAGAATTTGGAGTAGCA

Downstream 100 bases:

>100_bases
GATTGCTGGATCTTCCTGTTCGCCTCTCTTCCTCGATCGCTGGTGACGGGTTCAGGTTCAGGCATGGATCCTCGGGTCAA
GCCCGAGGATCCATGCCTGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MESASPSATIRRRGVMLVLSSPSGAGKSTIARSLLENDHEFELSVSVTTRPRRPSEIEGVHYHFKTQRDFEMMRDGGDLL
EWAEVHGNCYGTPRGPVERAIAGGRDMLFDIDWQGAAQLREKMPDDIVSVFILPPTMKELLARLTRRAEDTPEIIERRLR
NAHHEIEQWRDYDYVVINDDLDRAFASVRAIVSAERLRHERRPGLEDFVAGLLAERPE

Sequences:

>Translated_218_residues
MESASPSATIRRRGVMLVLSSPSGAGKSTIARSLLENDHEFELSVSVTTRPRRPSEIEGVHYHFKTQRDFEMMRDGGDLL
EWAEVHGNCYGTPRGPVERAIAGGRDMLFDIDWQGAAQLREKMPDDIVSVFILPPTMKELLARLTRRAEDTPEIIERRLR
NAHHEIEQWRDYDYVVINDDLDRAFASVRAIVSAERLRHERRPGLEDFVAGLLAERPE
>Mature_218_residues
MESASPSATIRRRGVMLVLSSPSGAGKSTIARSLLENDHEFELSVSVTTRPRRPSEIEGVHYHFKTQRDFEMMRDGGDLL
EWAEVHGNCYGTPRGPVERAIAGGRDMLFDIDWQGAAQLREKMPDDIVSVFILPPTMKELLARLTRRAEDTPEIIERRLR
NAHHEIEQWRDYDYVVINDDLDRAFASVRAIVSAERLRHERRPGLEDFVAGLLAERPE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=37.6288659793814, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=37.6288659793814, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=37.6288659793814, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI38570142, Length=193, Percent_Identity=27.979274611399, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=25, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI21361598, Length=199, Percent_Identity=28.643216080402, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=206, Percent_Identity=43.2038834951456, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=35.632183908046, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=35.632183908046, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=34.9726775956284, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=35.2331606217617, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI85724806, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007136, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554481, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554489, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640542, Length=194, Percent_Identity=28.3505154639175, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI161077626, Length=194, Percent_Identity=28.3505154639175, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_MESSB (Q11HG8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674322.1
- ProteinModelPortal:   Q11HG8
- SMR:   Q11HG8
- STRING:   Q11HG8
- GeneID:   4181199
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1763
- NMPDR:   fig|266779.1.peg.3704
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q11HG8
- ProtClustDB:   PRK00300
- BioCyc:   MSP266779:MESO_1763-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24890; Mature: 24890

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESASPSATIRRRGVMLVLSSPSGAGKSTIARSLLENDHEFELSVSVTTRPRRPSEIEGV
CCCCCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCE
HYHFKTQRDFEMMRDGGDLLEWAEVHGNCYGTPRGPVERAIAGGRDMLFDIDWQGAAQLR
EEEECCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHH
EKMPDDIVSVFILPPTMKELLARLTRRAEDTPEIIERRLRNAHHEIEQWRDYDYVVINDD
HHCCHHHHEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
LDRAFASVRAIVSAERLRHERRPGLEDFVAGLLAERPE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MESASPSATIRRRGVMLVLSSPSGAGKSTIARSLLENDHEFELSVSVTTRPRRPSEIEGV
CCCCCCCHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCE
HYHFKTQRDFEMMRDGGDLLEWAEVHGNCYGTPRGPVERAIAGGRDMLFDIDWQGAAQLR
EEEECCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHH
EKMPDDIVSVFILPPTMKELLARLTRRAEDTPEIIERRLRNAHHEIEQWRDYDYVVINDD
HHCCHHHHEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
LDRAFASVRAIVSAERLRHERRPGLEDFVAGLLAERPE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA