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The map label for this gene is pccB [H]

Identifier: 110634086

GI number: 110634086

Start: 1854499

End: 1856031

Strand: Direct

Name: pccB [H]

Synonym: Meso_1735

Alternate gene names: 110634086

Gene position: 1854499-1856031 (Clockwise)

Preceding gene: 110634085

Following gene: 110634088

Centisome position: 42.03

GC content: 58.71

Gene sequence:

>1533_bases
ATGAAGGACGTCCTTGAGGAACTCGAAAGGCGGCGTGCGGCGGCACGCGAGGGCGGCGGAAAGGCGCGCATCGCGCACCA
GCACGCCAAGGGAAAGCTCACCGCACGCGAGCGCCTCGAAGTGTTTCTGGACGAGGGCTCCTTCGAGGAGTTCGACATGT
TCGTCGAACATCGCTCGACTGATTTCGGCATGGAGAAGACGAAGATCGCCGGTGACGGAGTGGTAACCGGATGGGGCACG
GTGAATGGCCGTGCGGTCTTCGTCTTTGCCAAGGATTTTACTGTTTTCGGCGGCTCCCTCTCGGAGGCGCATGCGGAAAA
AGTGATGAAAGTCCAGGACATGGCACTCAAGAATCGAGCGCCGGTCATTGGCTTTTACGATGCAGGTGGCGCCCGGATTC
AGGAGGGCGTTGCAGCGCTCGGGGGTTATGCCGAGATATTCCAGCGCAATGTTCTGGCCTCCGGAGTAATCCCGCAAATA
TCCGTGATAATGGGCCCTTGCGCGGGCGGCGACGTCTATTCTCCGGCCATGACGGATTTCATCTTCATGGTCCGCGACAC
GTCCTACATGTTCGTCACAGGACCGGATGTGGTGAAAACCGTCACCAATGAATCGGTAACAGCGGAGGAGCTGGGCGGCG
CTCACGTCCACACGGTAAAATCTTCGATCGCGGATGGCGCCTATGACAACGATATCGAGGCATTGCTCCAGATGCGTCGA
CTGGTCGACTTCCTGCCCTCCTCGAACACGGCGGACATTCCCGATATAGAATTCAGTCCAGGCGACGGCGAGCCGGACCA
TTCCCTTGACCGGTTGATCCCGACCAATGCGAACAAGCCATACGACATTAAGGAGTTGATCCTGAAAACCGCCGATGAGG
GCGATTTCTTCGAAATACAGGAACACTTCGCCAGAAATATCGTCACCGGCTTCGGGCGCATCGAGGGGCGCACCGTCGGC
TTTGTCGCCAATCAGCCCATGGTGCTGGCCGGCGTGCTTGATTCCGATGCGTCGCGAAAAGCGGCGCGCTTCGTGCGCTT
CTGCGACTGCTTCAATATTCCGATCGTCACCTTTGTCGACGTGCCGGGATTTTTGCCCGGCACATCGCAGGAATATGGCG
GACTGATCAAACACGGCGCCAAGCTCCTTTTCGCCTATGCGGAGGCTACGGTGCCGAAAATAACGGTCATAACGCGCAAG
GCATTCGGCGGCGCCTATGACGTCATGGCCTCGAAGCATCTGCGCGGCGACATCAACTACGCCTGGCCGACGGCGCAGAT
CGCCGTGATGGGCGCCAAGGGCGCCGTCGAGATCATCTTCCGCAAGGACATCGCAGATGTGGAAAAGATTGCAGAGCACA
CCCGAAAATACGAGGAGCGTTTCCTCTCACCATTTGTCGCGGCGGAGCGCGGCTATGTGGACGAGGTGATCATGCCGCAC
TCCACCCGTCGGCGGATCGCCCGCGCGTTGCGAATGCTGCGTGGCAAGGATCTGCAAAATCCCTGGAAGAAGCACGACAA
CATTCCCCTTTGA

Upstream 100 bases:

>100_bases
GAATAAGGGAGTAAGGCAGCATGCAGCAGGGCCTCGAATAGGAAACCGAGCAAGTTCCCCCACTGCCCTGCTGCTGCCTG
CTCTGTCTGAGGGAGGGCAC

Downstream 100 bases:

>100_bases
GCATCAATGCAGGGTCGTCCCCTCGGGGTCGCGCAGTGGAGGGTGCGCCGGATAGGATTCGGGCCGTTCAAACAACATCG
CCGCGTCCATCGCCATCCCG

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKDVLEELERRRAAAREGGGKARIAHQHAKGKLTARERLEVFLDEGSFEEFDMFVEHRSTDFGMEKTKIAGDGVVTGWGT
VNGRAVFVFAKDFTVFGGSLSEAHAEKVMKVQDMALKNRAPVIGFYDAGGARIQEGVAALGGYAEIFQRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNESVTAEELGGAHVHTVKSSIADGAYDNDIEALLQMRR
LVDFLPSSNTADIPDIEFSPGDGEPDHSLDRLIPTNANKPYDIKELILKTADEGDFFEIQEHFARNIVTGFGRIEGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVDVPGFLPGTSQEYGGLIKHGAKLLFAYAEATVPKITVITRK
AFGGAYDVMASKHLRGDINYAWPTAQIAVMGAKGAVEIIFRKDIADVEKIAEHTRKYEERFLSPFVAAERGYVDEVIMPH
STRRRIARALRMLRGKDLQNPWKKHDNIPL

Sequences:

>Translated_510_residues
MKDVLEELERRRAAAREGGGKARIAHQHAKGKLTARERLEVFLDEGSFEEFDMFVEHRSTDFGMEKTKIAGDGVVTGWGT
VNGRAVFVFAKDFTVFGGSLSEAHAEKVMKVQDMALKNRAPVIGFYDAGGARIQEGVAALGGYAEIFQRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNESVTAEELGGAHVHTVKSSIADGAYDNDIEALLQMRR
LVDFLPSSNTADIPDIEFSPGDGEPDHSLDRLIPTNANKPYDIKELILKTADEGDFFEIQEHFARNIVTGFGRIEGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVDVPGFLPGTSQEYGGLIKHGAKLLFAYAEATVPKITVITRK
AFGGAYDVMASKHLRGDINYAWPTAQIAVMGAKGAVEIIFRKDIADVEKIAEHTRKYEERFLSPFVAAERGYVDEVIMPH
STRRRIARALRMLRGKDLQNPWKKHDNIPL
>Mature_510_residues
MKDVLEELERRRAAAREGGGKARIAHQHAKGKLTARERLEVFLDEGSFEEFDMFVEHRSTDFGMEKTKIAGDGVVTGWGT
VNGRAVFVFAKDFTVFGGSLSEAHAEKVMKVQDMALKNRAPVIGFYDAGGARIQEGVAALGGYAEIFQRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVRDTSYMFVTGPDVVKTVTNESVTAEELGGAHVHTVKSSIADGAYDNDIEALLQMRR
LVDFLPSSNTADIPDIEFSPGDGEPDHSLDRLIPTNANKPYDIKELILKTADEGDFFEIQEHFARNIVTGFGRIEGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVDVPGFLPGTSQEYGGLIKHGAKLLFAYAEATVPKITVITRK
AFGGAYDVMASKHLRGDINYAWPTAQIAVMGAKGAVEIIFRKDIADVEKIAEHTRKYEERFLSPFVAAERGYVDEVIMPH
STRRRIARALRMLRGKDLQNPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=60.7072691552063, Blast_Score=634, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=58.6011342155009, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI11545863, Length=500, Percent_Identity=32.6, Blast_Score=229, Evalue=5e-60,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=61.5384615384615, Blast_Score=657, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=61.5384615384615, Blast_Score=656, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=525, Percent_Identity=32.3809523809524, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24586065, Length=524, Percent_Identity=32.2519083969466, Blast_Score=240, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56119; Mature: 56119

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVLEELERRRAAAREGGGKARIAHQHAKGKLTARERLEVFLDEGSFEEFDMFVEHRST
CHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCC
DFGMEKTKIAGDGVVTGWGTVNGRAVFVFAKDFTVFGGSLSEAHAEKVMKVQDMALKNRA
CCCCCCEEECCCCEEEECCCCCCEEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHCCC
PVIGFYDAGGARIQEGVAALGGYAEIFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPDVVKTVTNESVTAEELGGAHVHTVKSSIADGAYDNDIEALLQMRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LVDFLPSSNTADIPDIEFSPGDGEPDHSLDRLIPTNANKPYDIKELILKTADEGDFFEIQ
HHHHCCCCCCCCCCCCEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHH
EHFARNIVTGFGRIEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVD
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTSQEYGGLIKHGAKLLFAYAEATVPKITVITRKAFGGAYDVMASKHLRGDINY
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEEHHCCCHHHHHHHHHHCCCCCC
AWPTAQIAVMGAKGAVEIIFRKDIADVEKIAEHTRKYEERFLSPFVAAERGYVDEVIMPH
CCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
STRRRIARALRMLRGKDLQNPWKKHDNIPL
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKDVLEELERRRAAAREGGGKARIAHQHAKGKLTARERLEVFLDEGSFEEFDMFVEHRST
CHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCC
DFGMEKTKIAGDGVVTGWGTVNGRAVFVFAKDFTVFGGSLSEAHAEKVMKVQDMALKNRA
CCCCCCEEECCCCEEEECCCCCCEEEEEEEECEEEECCCHHHHHHHHHHHHHHHHHHCCC
PVIGFYDAGGARIQEGVAALGGYAEIFQRNVLASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVRDTSYMFVTGPDVVKTVTNESVTAEELGGAHVHTVKSSIADGAYDNDIEALLQMRR
EEEEECCCEEEEECCHHHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LVDFLPSSNTADIPDIEFSPGDGEPDHSLDRLIPTNANKPYDIKELILKTADEGDFFEIQ
HHHHCCCCCCCCCCCCEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHH
EHFARNIVTGFGRIEGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDCFNIPIVTFVD
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTSQEYGGLIKHGAKLLFAYAEATVPKITVITRKAFGGAYDVMASKHLRGDINY
CCCCCCCCCHHHCHHHHHHHHHEEHHHHCCCCEEEEEEEHHCCCHHHHHHHHHHCCCCCC
AWPTAQIAVMGAKGAVEIIFRKDIADVEKIAEHTRKYEERFLSPFVAAERGYVDEVIMPH
CCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
STRRRIARALRMLRGKDLQNPWKKHDNIPL
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]