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The map label for this gene is gloA [H]

Identifier: 110634085

GI number: 110634085

Start: 1853950

End: 1854390

Strand: Direct

Name: gloA [H]

Synonym: Meso_1734

Alternate gene names: 110634085

Gene position: 1853950-1854390 (Clockwise)

Preceding gene: 110634077

Following gene: 110634086

Centisome position: 42.02

GC content: 57.82

Gene sequence:

>441_bases
ATGCGTTACCTGCACACGATGGTCCGCGTACGCGATATCGGTGAATCGCTGGATTTTTATTGCAACAAGCTCGGCATGAA
GGAGGTGCGGCGCATTGAGAATGAGGCAGGGCGCTTTACGCTGATCTTTCTCGCCGCTCCAGAGGACGTCGAAGCAGCCG
AGCGCCACAAGGCGCCGCTCGTGGAATTGACCTACAACTGGGATCCGGAAGATTATCAAGGCGGCCGCAATTTCGGCCAT
CTGGCCTATGAGGTGGACGACATTTACGCATTTTGCCAGCACCTTATGGACGCAGGCATCACCATTAACCGTCCTCCCCG
TGACGGCAACATGGCATTCATCCGTTCACCCGACGGCATCTCCATCGAGATTCTGCAGAAGGGCGAAGCCAAGCCCAAGG
CCGAGCCGTGGGCCTCTATGCCGAACACGGGGGCGTGGTAG

Upstream 100 bases:

>100_bases
GCATAATTCCGGCATAAGTGGGAACGGGGAATTGCCCATTGGCGCTTCATGCGCCAGCGCTCTATCTTGCTATCGAACCG
GAAGAAGAAAAGGAGAGCCC

Downstream 100 bases:

>100_bases
CATCAAGGGAATAAGGGAGTAAGGCAGCATGCAGCAGGGCCTCGAATAGGAAACCGAGCAAGTTCCCCCACTGCCCTGCT
GCTGCCTGCTCTGTCTGAGG

Product: glyoxalase/bleomycin resistance protein/dioxygenase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MRYLHTMVRVRDIGESLDFYCNKLGMKEVRRIENEAGRFTLIFLAAPEDVEAAERHKAPLVELTYNWDPEDYQGGRNFGH
LAYEVDDIYAFCQHLMDAGITINRPPRDGNMAFIRSPDGISIEILQKGEAKPKAEPWASMPNTGAW

Sequences:

>Translated_146_residues
MRYLHTMVRVRDIGESLDFYCNKLGMKEVRRIENEAGRFTLIFLAAPEDVEAAERHKAPLVELTYNWDPEDYQGGRNFGH
LAYEVDDIYAFCQHLMDAGITINRPPRDGNMAFIRSPDGISIEILQKGEAKPKAEPWASMPNTGAW
>Mature_146_residues
MRYLHTMVRVRDIGESLDFYCNKLGMKEVRRIENEAGRFTLIFLAAPEDVEAAERHKAPLVELTYNWDPEDYQGGRNFGH
LAYEVDDIYAFCQHLMDAGITINRPPRDGNMAFIRSPDGISIEILQKGEAKPKAEPWASMPNTGAW

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

Organism=Homo sapiens, GI118402586, Length=143, Percent_Identity=38.4615384615385, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787940, Length=136, Percent_Identity=38.2352941176471, Blast_Score=93, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323639, Length=142, Percent_Identity=34.5070422535211, Blast_Score=81, Evalue=8e-17,
Organism=Drosophila melanogaster, GI20129743, Length=144, Percent_Identity=34.0277777777778, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 16689; Mature: 16689

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLHTMVRVRDIGESLDFYCNKLGMKEVRRIENEAGRFTLIFLAAPEDVEAAERHKAPL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCE
VELTYNWDPEDYQGGRNFGHLAYEVDDIYAFCQHLMDAGITINRPPRDGNMAFIRSPDGI
EEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCC
SIEILQKGEAKPKAEPWASMPNTGAW
EEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRYLHTMVRVRDIGESLDFYCNKLGMKEVRRIENEAGRFTLIFLAAPEDVEAAERHKAPL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCE
VELTYNWDPEDYQGGRNFGHLAYEVDDIYAFCQHLMDAGITINRPPRDGNMAFIRSPDGI
EEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCC
SIEILQKGEAKPKAEPWASMPNTGAW
EEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]