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The map label for this gene is trpD

Identifier: 110633990

GI number: 110633990

Start: 1765530

End: 1766546

Strand: Direct

Name: trpD

Synonym: Meso_1638

Alternate gene names: 110633990

Gene position: 1765530-1766546 (Clockwise)

Preceding gene: 110633989

Following gene: 110633991

Centisome position: 40.01

GC content: 64.7

Gene sequence:

>1017_bases
ATGGCTGATCTCAAGGCACATATCGCCAAAGTGGCTTCCGGAGCTGCGCTGAGCTTTGCCGAAGCGCGTGAAGCTTTCGG
GATCATCATGTCCGGCGAGGCCACACCAAGCCAGATCGGCGGATTTCTGATGGCGCTGCGCGTGCGCGGCGAGACGGTGG
ATGAAATCAGCGGCGCGGTCGATACGATGCGCTCCAAGATGCTGCCGGTCACCGCTCCGGCCGAAGCGGTCGATATCGTG
GGCACCGGGGGCGACGCTTCGGGAACCTACAATGTCTCGACCTGCGCAGCCTTCATAGTCGCCGGCTGCGGCGTTCCGGT
TGCCAAGCATGGCAACCGCGCACTCTCCTCGAAATCGGGAGCAGCCGACAGCCTCGTCGCGCTCGGCGTCAATATCGAGC
TCGGGCCTGACCAGATAGCCGCCTGCATCGCCGAGGCCGGTGTCGGCTTCATGTTCGCACCCAGCCACCACGCGGCGATG
CGCCATGTGGGGCCGACGCGTGTGGAGCTCGGCACCAGAACGATCTTCAATCTCTTAGGGCCTCTATCGAATCCGGCGGG
CGTTAAAAGGCAGCTCGTCGGAGTCTTCTCGGCCCAATGGGTGGAGCCTCTGGCGCATGTCCTGCGGCAGTTGGGAACGG
AAAAGGCCTGGGTCGTGCACGGAGACGGGCTTGACGAAATGACGACCGCCGGCGTCACCCGGGTGGCCTCCCTGGAGTAT
GGCGAGGTGAGGACCTTCGAAATCACCCCCGAAGAGGTTGGATTGCAGCGGTCTGCGGCCGCGGCCCTCAAGGGCGGCGA
CGGCGAGTATAACGGCAAGGCTCTGCGCCGGGTGCTTGAGGGCGAACGGAACGCCTATCGCGACATCGCCGTTCTGAATG
CCGGCGGCGCGCTGATCGTCGCGGGCAAGGCAGAGACCCTGAAAGACGCTGTCGCCCTCGCCTCGGAGTCGATCGAAAGT
GGCCGGGCGCTGGCCGCGCTCGAGAAGCTCGTCGAGGTTTCCAACCGGAAACCCTGA

Upstream 100 bases:

>100_bases
GGAAAACGACCTTCTCGACCAGCTCGTGACGCGCCTCCAGGCCGAGCATGGCGTCACGGTAAATCGCACGGCAATGCAGC
AAGCACTCGCCTTCTGACCA

Downstream 100 bases:

>100_bases
GGATAAACTTAGGATCATGGCTGACATTCTTCGAAAGATCGAAGCTTACAAGCGCGAGGAGATTGCGGCTGCGAAGCAAG
CTCTACCTCTGGCCGAGCAG

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MADLKAHIAKVASGAALSFAEAREAFGIIMSGEATPSQIGGFLMALRVRGETVDEISGAVDTMRSKMLPVTAPAEAVDIV
GTGGDASGTYNVSTCAAFIVAGCGVPVAKHGNRALSSKSGAADSLVALGVNIELGPDQIAACIAEAGVGFMFAPSHHAAM
RHVGPTRVELGTRTIFNLLGPLSNPAGVKRQLVGVFSAQWVEPLAHVLRQLGTEKAWVVHGDGLDEMTTAGVTRVASLEY
GEVRTFEITPEEVGLQRSAAAALKGGDGEYNGKALRRVLEGERNAYRDIAVLNAGGALIVAGKAETLKDAVALASESIES
GRALAALEKLVEVSNRKP

Sequences:

>Translated_338_residues
MADLKAHIAKVASGAALSFAEAREAFGIIMSGEATPSQIGGFLMALRVRGETVDEISGAVDTMRSKMLPVTAPAEAVDIV
GTGGDASGTYNVSTCAAFIVAGCGVPVAKHGNRALSSKSGAADSLVALGVNIELGPDQIAACIAEAGVGFMFAPSHHAAM
RHVGPTRVELGTRTIFNLLGPLSNPAGVKRQLVGVFSAQWVEPLAHVLRQLGTEKAWVVHGDGLDEMTTAGVTRVASLEY
GEVRTFEITPEEVGLQRSAAAALKGGDGEYNGKALRRVLEGERNAYRDIAVLNAGGALIVAGKAETLKDAVALASESIES
GRALAALEKLVEVSNRKP
>Mature_337_residues
ADLKAHIAKVASGAALSFAEAREAFGIIMSGEATPSQIGGFLMALRVRGETVDEISGAVDTMRSKMLPVTAPAEAVDIVG
TGGDASGTYNVSTCAAFIVAGCGVPVAKHGNRALSSKSGAADSLVALGVNIELGPDQIAACIAEAGVGFMFAPSHHAAMR
HVGPTRVELGTRTIFNLLGPLSNPAGVKRQLVGVFSAQWVEPLAHVLRQLGTEKAWVVHGDGLDEMTTAGVTRVASLEYG
EVRTFEITPEEVGLQRSAAAALKGGDGEYNGKALRRVLEGERNAYRDIAVLNAGGALIVAGKAETLKDAVALASESIESG
RALAALEKLVEVSNRKP

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=280, Percent_Identity=41.7857142857143, Blast_Score=220, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320561, Length=363, Percent_Identity=28.9256198347107, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_MESSB (Q11HU2)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674198.1
- ProteinModelPortal:   Q11HU2
- SMR:   Q11HU2
- STRING:   Q11HU2
- GeneID:   4179237
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1638
- NMPDR:   fig|266779.1.peg.384
- eggNOG:   COG0547
- HOGENOM:   HBG559996
- OMA:   ATPSQMG
- PhylomeDB:   Q11HU2
- ProtClustDB:   PRK00188
- BioCyc:   MSP266779:MESO_1638-MONOMER
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 34865; Mature: 34734

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLKAHIAKVASGAALSFAEAREAFGIIMSGEATPSQIGGFLMALRVRGETVDEISGAV
CCCHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHH
DTMRSKMLPVTAPAEAVDIVGTGGDASGTYNVSTCAAFIVAGCGVPVAKHGNRALSSKSG
HHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCHHHCCCCC
AADSLVALGVNIELGPDQIAACIAEAGVGFMFAPSHHAAMRHVGPTRVELGTRTIFNLLG
CCCCEEEEEEEEEECHHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHHHHHHHHHHHC
PLSNPAGVKRQLVGVFSAQWVEPLAHVLRQLGTEKAWVVHGDGLDEMTTAGVTRVASLEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCC
GEVRTFEITPEEVGLQRSAAAALKGGDGEYNGKALRRVLEGERNAYRDIAVLNAGGALIV
CCEEEEEECHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHEEEEEECCCEEEE
AGKAETLKDAVALASESIESGRALAALEKLVEVSNRKP
ECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADLKAHIAKVASGAALSFAEAREAFGIIMSGEATPSQIGGFLMALRVRGETVDEISGAV
CCHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHH
DTMRSKMLPVTAPAEAVDIVGTGGDASGTYNVSTCAAFIVAGCGVPVAKHGNRALSSKSG
HHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCHHHCCCCC
AADSLVALGVNIELGPDQIAACIAEAGVGFMFAPSHHAAMRHVGPTRVELGTRTIFNLLG
CCCCEEEEEEEEEECHHHHHHHHHHCCCCEEECCCHHHHHHCCCCCHHHHHHHHHHHHHC
PLSNPAGVKRQLVGVFSAQWVEPLAHVLRQLGTEKAWVVHGDGLDEMTTAGVTRVASLEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCC
GEVRTFEITPEEVGLQRSAAAALKGGDGEYNGKALRRVLEGERNAYRDIAVLNAGGALIV
CCEEEEEECHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHEEEEEECCCEEEE
AGKAETLKDAVALASESIESGRALAALEKLVEVSNRKP
ECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA