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The map label for this gene is trpC

Identifier: 110633991

GI number: 110633991

Start: 1766563

End: 1767378

Strand: Direct

Name: trpC

Synonym: Meso_1639

Alternate gene names: 110633991

Gene position: 1766563-1767378 (Clockwise)

Preceding gene: 110633990

Following gene: 110633992

Centisome position: 40.04

GC content: 60.91

Gene sequence:

>816_bases
ATGGCTGACATTCTTCGAAAGATCGAAGCTTACAAGCGCGAGGAGATTGCGGCTGCGAAGCAAGCTCTACCTCTGGCCGA
GCAGGCTGCACGGGCACGGGATGCCGCTCCCATACGCGGGTTTGCGGCGGCGCTGCGCTCAAAGCATGCTGCAGGGCAGT
TCGCGCTGATCGCGGAGGTGAAGAAGGCAAGCCCCTCCAAGGGCCTCATTCGAGCCGATTTCGATCCCCCAACTCTTGCA
AAAGCCTATGAAGACGGTGGAGCTGCCTGCCTTTCCGTGCTCACGGACCGTCCCTCCTTCCAGGGCGCGCCCGAGTTCCT
GACTGCGGCGCGGGCTGCCACGAACCTGCCTGCCCTGCGCAAGGACTTCATGTTCGAGCCCTATCAGGTGTTCGAAGCAC
GCGCTTGGGGCGCGGATGCGATCCTGATCATTATGGCGAGCGTCTCGGATGACGAGGCTATCAATCTCTCGGAGACAGCG
GGCGAACTCGGCATGGACATCCTGCTGGAAGTCCACGACGAAGCCGAGCTGGAAAGGGCGCTAAAACTCCCCTCGCCCTT
GATCGGCATCAACAACCGCAATCTCCGCACCTTCGAAACGACCCTGGAAACCAGCGAACGCCTCGCGCCTCTGGTGCCGG
AGGATCGAGTCATCGTGGGTGAGAGCGGTATCTTCACCCACGCCGATTGTCTCCGGCTCAAGAAAGTCGGCATTTCCACA
TTCCTTGTGGGCGAAAGCCTGATGCGCCAGAACGATGTCGAGGCCGCAACGCGGAGCCTTCTTGGCCTACAGCGGAATAT
CGAGGCAGTGAGCTGA

Upstream 100 bases:

>100_bases
GCCCTCGCCTCGGAGTCGATCGAAAGTGGCCGGGCGCTGGCCGCGCTCGAGAAGCTCGTCGAGGTTTCCAACCGGAAACC
CTGAGGATAAACTTAGGATC

Downstream 100 bases:

>100_bases
TGGCCAATGAAGCCGGGAGCAGGCTAACCCATCTGCGTGCCGATGGCCGCGCTGAGATGGTCGATATCGGCGCCAAGCAG
GAGACCGAGCGCGCGGCGAT

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MADILRKIEAYKREEIAAAKQALPLAEQAARARDAAPIRGFAAALRSKHAAGQFALIAEVKKASPSKGLIRADFDPPTLA
KAYEDGGAACLSVLTDRPSFQGAPEFLTAARAATNLPALRKDFMFEPYQVFEARAWGADAILIIMASVSDDEAINLSETA
GELGMDILLEVHDEAELERALKLPSPLIGINNRNLRTFETTLETSERLAPLVPEDRVIVGESGIFTHADCLRLKKVGIST
FLVGESLMRQNDVEAATRSLLGLQRNIEAVS

Sequences:

>Translated_271_residues
MADILRKIEAYKREEIAAAKQALPLAEQAARARDAAPIRGFAAALRSKHAAGQFALIAEVKKASPSKGLIRADFDPPTLA
KAYEDGGAACLSVLTDRPSFQGAPEFLTAARAATNLPALRKDFMFEPYQVFEARAWGADAILIIMASVSDDEAINLSETA
GELGMDILLEVHDEAELERALKLPSPLIGINNRNLRTFETTLETSERLAPLVPEDRVIVGESGIFTHADCLRLKKVGIST
FLVGESLMRQNDVEAATRSLLGLQRNIEAVS
>Mature_270_residues
ADILRKIEAYKREEIAAAKQALPLAEQAARARDAAPIRGFAAALRSKHAAGQFALIAEVKKASPSKGLIRADFDPPTLAK
AYEDGGAACLSVLTDRPSFQGAPEFLTAARAATNLPALRKDFMFEPYQVFEARAWGADAILIIMASVSDDEAINLSETAG
ELGMDILLEVHDEAELERALKLPSPLIGINNRNLRTFETTLETSERLAPLVPEDRVIVGESGIFTHADCLRLKKVGISTF
LVGESLMRQNDVEAATRSLLGLQRNIEAVS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=39.463601532567, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=36.7521367521368, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_MESSB (Q11HU1)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674199.1
- ProteinModelPortal:   Q11HU1
- SMR:   Q11HU1
- STRING:   Q11HU1
- GeneID:   4179238
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1639
- NMPDR:   fig|266779.1.peg.385
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- PhylomeDB:   Q11HU1
- BioCyc:   MSP266779:MESO_1639-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29340; Mature: 29209

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADILRKIEAYKREEIAAAKQALPLAEQAARARDAAPIRGFAAALRSKHAAGQFALIAEV
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHH
KKASPSKGLIRADFDPPTLAKAYEDGGAACLSVLTDRPSFQGAPEFLTAARAATNLPALR
HHCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHH
KDFMFEPYQVFEARAWGADAILIIMASVSDDEAINLSETAGELGMDILLEVHDEAELERA
HHHCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHCHHHEEEECCHHHHHHH
LKLPSPLIGINNRNLRTFETTLETSERLAPLVPEDRVIVGESGIFTHADCLRLKKVGIST
HCCCCCEEECCCCCCEEHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHHHHHHHCHHH
FLVGESLMRQNDVEAATRSLLGLQRNIEAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADILRKIEAYKREEIAAAKQALPLAEQAARARDAAPIRGFAAALRSKHAAGQFALIAEV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHH
KKASPSKGLIRADFDPPTLAKAYEDGGAACLSVLTDRPSFQGAPEFLTAARAATNLPALR
HHCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHH
KDFMFEPYQVFEARAWGADAILIIMASVSDDEAINLSETAGELGMDILLEVHDEAELERA
HHHCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHCHHHEEEECCHHHHHHH
LKLPSPLIGINNRNLRTFETTLETSERLAPLVPEDRVIVGESGIFTHADCLRLKKVGIST
HCCCCCEEECCCCCCEEHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHHHHHHHCHHH
FLVGESLMRQNDVEAATRSLLGLQRNIEAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA