Click here to switch to the map view.

The map label for this gene is kdsA

Identifier: 110633985

GI number: 110633985

Start: 1759311

End: 1760141

Strand: Reverse

Name: kdsA

Synonym: Meso_1633

Alternate gene names: 110633985

Gene position: 1760141-1759311 (Counterclockwise)

Preceding gene: 110633986

Following gene: 110633984

Centisome position: 39.89

GC content: 62.94

Gene sequence:

>831_bases
ATGATACCCAATCCACGGGTGGAAATCGGCCAAGCCGTCTTCGCCAACGACGCCCCGCTCGCGCTGATCGCGGGACCTTG
CCAGCTCGAAAGCCGCGAGCATGCGTTCGAAATGGCCGGCCGGCTGAAGGAGATGGCGGAAAAGCTCGGTCTCGGTTTCG
TCTACAAGACGAGCTTCGACAAGGCGAACCGCACCTCGCTGCTGGGCAAACGCGGAGCCGGCCTGGATGCTGCGCTCCCG
ATTTTCGCCGATCTCCGGCGTGAGCTCGGCGTGCCCGTGCTCACCGATGTCCACACGGAAGGGCAATGCGAAATCTTGGC
GGATGCTGTGGATGTGCTGCAGATCCCGGCTTTCCTTTGCCGGCAGACAGACCTGCTCGTCGCTGCTGCCAAGACGGGCA
AGGTCGTAAACGTGAAAAAGGGACAATTTCTGGCACCCTGGGACATGAAGAATGTCGTCGCCAAGATCACGGCTTCCGGC
AATCCGAACGTGCTGACAACCGAACGCGGCGTCTCCTTCGGCTACAACACTCTCGTCACCGACATGCGCGCCCTACCCAT
CATGGCGGAGATCGGCGCGCCCGTGATTTTCGATGCCACCCATTCGGTGCAGCAGCCGGGCGGGCAGGGGAGCTCCTCCG
GCGGCGACCGGCGCTTCGTGGAAACCCTTGCGCGGGCTGCGGTGGCGGTCGGCGTGGCTGGCGTCTTCATTGAGACTCAT
CAGGACCCCGATAATGCCCCCTCCGATGGGCCGAATATGGTGCAGCTCGACAAAATGCCGGCGCTCCTGGAGCGGCTGAT
GGCCTTCGACCGGATCGCGAAGAGCAAGTGA

Upstream 100 bases:

>100_bases
TGACCTGGGGATCCGCGCCTGATTATCGGGGCTTTGCCGGCAGTCGAAAGTAGCTTCGATTGGCCGTTGCCCGAGGGGGC
CGCCAGATGGAGTTCGAACA

Downstream 100 bases:

>100_bases
ACCGGTAGCCTTCAGGCCGGAGAGGATGCGCCAAAGCGCTTCCCAAAGCAGCGCAACCGCATTGTCTTTTTTGTCGTGTA
GGGTAAGAGGAGCGCAATTT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MIPNPRVEIGQAVFANDAPLALIAGPCQLESREHAFEMAGRLKEMAEKLGLGFVYKTSFDKANRTSLLGKRGAGLDAALP
IFADLRRELGVPVLTDVHTEGQCEILADAVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVAKITASG
NPNVLTTERGVSFGYNTLVTDMRALPIMAEIGAPVIFDATHSVQQPGGQGSSSGGDRRFVETLARAAVAVGVAGVFIETH
QDPDNAPSDGPNMVQLDKMPALLERLMAFDRIAKSK

Sequences:

>Translated_276_residues
MIPNPRVEIGQAVFANDAPLALIAGPCQLESREHAFEMAGRLKEMAEKLGLGFVYKTSFDKANRTSLLGKRGAGLDAALP
IFADLRRELGVPVLTDVHTEGQCEILADAVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVAKITASG
NPNVLTTERGVSFGYNTLVTDMRALPIMAEIGAPVIFDATHSVQQPGGQGSSSGGDRRFVETLARAAVAVGVAGVFIETH
QDPDNAPSDGPNMVQLDKMPALLERLMAFDRIAKSK
>Mature_276_residues
MIPNPRVEIGQAVFANDAPLALIAGPCQLESREHAFEMAGRLKEMAEKLGLGFVYKTSFDKANRTSLLGKRGAGLDAALP
IFADLRRELGVPVLTDVHTEGQCEILADAVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVAKITASG
NPNVLTTERGVSFGYNTLVTDMRALPIMAEIGAPVIFDATHSVQQPGGQGSSSGGDRRFVETLARAAVAVGVAGVFIETH
QDPDNAPSDGPNMVQLDKMPALLERLMAFDRIAKSK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=270, Percent_Identity=46.6666666666667, Blast_Score=244, Evalue=3e-66,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_MESSB (Q11HU7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_674193.1
- ProteinModelPortal:   Q11HU7
- SMR:   Q11HU7
- STRING:   Q11HU7
- GeneID:   4179232
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1633
- NMPDR:   fig|266779.1.peg.379
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   RSLPIMA
- PhylomeDB:   Q11HU7
- ProtClustDB:   PRK05198
- BioCyc:   MSP266779:MESO_1633-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 29463; Mature: 29463

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNPRVEIGQAVFANDAPLALIAGPCQLESREHAFEMAGRLKEMAEKLGLGFVYKTSFD
CCCCCCCHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCC
KANRTSLLGKRGAGLDAALPIFADLRRELGVPVLTDVHTEGQCEILADAVDVLQIPAFLC
CCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
RQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVAKITASGNPNVLTTERGVSFGYNTLVT
CCCCCEEEEECCCCEEEECCCCEECCCCHHHHHEEEECCCCCCEEEECCCCCCCHHHHHH
DMRALPIMAEIGAPVIFDATHSVQQPGGQGSSSGGDRRFVETLARAAVAVGVAGVFIETH
HHHHHHHHHHCCCCEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
QDPDNAPSDGPNMVQLDKMPALLERLMAFDRIAKSK
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPNPRVEIGQAVFANDAPLALIAGPCQLESREHAFEMAGRLKEMAEKLGLGFVYKTSFD
CCCCCCCHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCC
KANRTSLLGKRGAGLDAALPIFADLRRELGVPVLTDVHTEGQCEILADAVDVLQIPAFLC
CCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
RQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVAKITASGNPNVLTTERGVSFGYNTLVT
CCCCCEEEEECCCCEEEECCCCEECCCCHHHHHEEEECCCCCCEEEECCCCCCCHHHHHH
DMRALPIMAEIGAPVIFDATHSVQQPGGQGSSSGGDRRFVETLARAAVAVGVAGVFIETH
HHHHHHHHHHCCCCEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
QDPDNAPSDGPNMVQLDKMPALLERLMAFDRIAKSK
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA