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The map label for this gene is pyrG [H]

Identifier: 110633986

GI number: 110633986

Start: 1760329

End: 1761966

Strand: Reverse

Name: pyrG [H]

Synonym: Meso_1634

Alternate gene names: 110633986

Gene position: 1761966-1760329 (Counterclockwise)

Preceding gene: 110633987

Following gene: 110633985

Centisome position: 39.93

GC content: 61.36

Gene sequence:

>1638_bases
ATGAGTCCCATGGCGCGATATGTTTTCATAACCGGCGGCGTGGTTTCCTCCCTCGGCAAAGGCATTGCATCGGCGGCTCT
CGGCGCGCTGCTGCAGGCACGCGGGTACCGCGTCCGATTGAGGAAGCTCGATCCCTATCTCAACGTCGATCCCGGCACGA
TGTCGCCGTATCAGCACGGCGAGGTTTTCGTTACCGACGACGGGGCGGAGACGGATCTCGATCTCGGGCATTACGAGCGC
TTCACAGGGCGCTCGGCCAACAAGCGGGATAACATCACCACGGGCCGCATCTACCAGAATATCATCGAGAAGGAGCGGCG
CGGCGATTACCTCGGCGCCACAGTGCAGGTGATCCCTCACGTCACTGACGAGATCAAGCAATTCGTACTCGAAGGCAACG
AGGAGTTTGATTTCGTGCTCTGCGAAATCGGCGGCACGGTGGGCGATATCGAGGCGATGCCCTTCCTCGAAGCCATCCGC
CAACTTGGCAACGAACTGCCGCGCGGCAACGCCGTCTACATCCATCTGACGCTGATGCCCTGGATTCCGGCGGCGGGCGA
GCTCAAGACCAAGCCCACCCAGCACTCCGTCAAGGAGCTTCGCTCGATCGGTATCGCACCCGATATCCTGCTCGTGCGGG
CCGACCGGCCGGTTCCGCCTGAGGAGCGACGTAAGCTCTCGCTCTTTTGCAATGTGCGCGAATCGGCCGTCATCCAGGCC
CTCGATGTGGCGCATATCTACGATGTTCCGATGGCCTATCATAAGGAAGGCCTTGATTCGGAGGTGCTTGCCGCCTTCGG
GATCGACCCTGCGCCCAAGCCGCGGATGGAGCGTTGGGAGGAGGTCTCGAACCGGATTCACAATCCGGAAGGCGAGGTGA
CGATTGCAATCGTCGGCAAATATACCGGCCTCAAGGATGCCTATAAGTCGCTTAACGAGGCGCTTACGCATGGCGGCATC
GCCAATCGGGTGCGCGTGAAGCTGGATTGGATCGAATCTGAGATTTTCGAGAAGGAAGATCCGGCGCCGTGGCTGGAGAA
GGTGCACGGCATTCTGGTGCCCGGCGGCTTTGGCGAGCGTGGCTCCGAGGGCAAGATCCTGGCAGCGAAATTCGCGCGCG
AGCGGAAAGTGCCCTATTTCGGCATATGTTTCGGCATGCAGATGGCCTGCATAGAGGCTGCCCGCTCGCTCGCGGGCATC
GAGAAGGCGTCCTCCACCGAATTCGGACCGACAAAGGAGCCGGTGGTTGGCCTGATGACCGAGTGGCTGCGCGGCAACAT
GCTGGAGAAGCGCACGGCGGCCGGCGATCTGGGCGGTACGATGCGGCTCGGCGCTTACGAGGCACGGCTCCAGCCTGGCT
CAAAAATCGCGGAAATCTACGGCAGCGAAGAGATATCCGAACGCCACCGCCATCGCTATGAGGTCAATATCGGCTACCGC
GAGAAGCTTGAGGCGTGCGGACTTGTCTTCGCCGGCCTTTCGCCTGACGGCGTGCTGCCGGAAACGATAGAGTACCCAGA
CCACCCCTGGTTTGTCGGCGTGCAGTACCATCCGGAACTGAAGAGCCGGCCCTTCGAGCCGCACCCGCTTTTTGCTTCCT
TCATCGCCGCCGCCGTGGAGCAGTCGCGTCTGGTTTAG

Upstream 100 bases:

>100_bases
CTTCAAGCCGCCCGCGCGAATGCGTCGAACCCGTTATACATAGAAAAGAAGCAGGCATGGGCATTTTGTTGTGGCGGAAT
CGCTCGCGCCGAGCTATGCG

Downstream 100 bases:

>100_bases
CGCCGCGGAGATGCCGAACATTCCCGAGGACGGGTTCGTTTTGATGCGCTTGCGATTTTGAGACCGCTCAGGCAAGGATC
CCGATCTTGACCTGGGGATC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MSPMARYVFITGGVVSSLGKGIASAALGALLQARGYRVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYER
FTGRSANKRDNITTGRIYQNIIEKERRGDYLGATVQVIPHVTDEIKQFVLEGNEEFDFVLCEIGGTVGDIEAMPFLEAIR
QLGNELPRGNAVYIHLTLMPWIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADRPVPPEERRKLSLFCNVRESAVIQA
LDVAHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMERWEEVSNRIHNPEGEVTIAIVGKYTGLKDAYKSLNEALTHGGI
ANRVRVKLDWIESEIFEKEDPAPWLEKVHGILVPGGFGERGSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGI
EKASSTEFGPTKEPVVGLMTEWLRGNMLEKRTAAGDLGGTMRLGAYEARLQPGSKIAEIYGSEEISERHRHRYEVNIGYR
EKLEACGLVFAGLSPDGVLPETIEYPDHPWFVGVQYHPELKSRPFEPHPLFASFIAAAVEQSRLV

Sequences:

>Translated_545_residues
MSPMARYVFITGGVVSSLGKGIASAALGALLQARGYRVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYER
FTGRSANKRDNITTGRIYQNIIEKERRGDYLGATVQVIPHVTDEIKQFVLEGNEEFDFVLCEIGGTVGDIEAMPFLEAIR
QLGNELPRGNAVYIHLTLMPWIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADRPVPPEERRKLSLFCNVRESAVIQA
LDVAHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMERWEEVSNRIHNPEGEVTIAIVGKYTGLKDAYKSLNEALTHGGI
ANRVRVKLDWIESEIFEKEDPAPWLEKVHGILVPGGFGERGSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGI
EKASSTEFGPTKEPVVGLMTEWLRGNMLEKRTAAGDLGGTMRLGAYEARLQPGSKIAEIYGSEEISERHRHRYEVNIGYR
EKLEACGLVFAGLSPDGVLPETIEYPDHPWFVGVQYHPELKSRPFEPHPLFASFIAAAVEQSRLV
>Mature_544_residues
SPMARYVFITGGVVSSLGKGIASAALGALLQARGYRVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERF
TGRSANKRDNITTGRIYQNIIEKERRGDYLGATVQVIPHVTDEIKQFVLEGNEEFDFVLCEIGGTVGDIEAMPFLEAIRQ
LGNELPRGNAVYIHLTLMPWIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADRPVPPEERRKLSLFCNVRESAVIQAL
DVAHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMERWEEVSNRIHNPEGEVTIAIVGKYTGLKDAYKSLNEALTHGGIA
NRVRVKLDWIESEIFEKEDPAPWLEKVHGILVPGGFGERGSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGIE
KASSTEFGPTKEPVVGLMTEWLRGNMLEKRTAAGDLGGTMRLGAYEARLQPGSKIAEIYGSEEISERHRHRYEVNIGYRE
KLEACGLVFAGLSPDGVLPETIEYPDHPWFVGVQYHPELKSRPFEPHPLFASFIAAAVEQSRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=43.6265709156194, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI28559085, Length=563, Percent_Identity=43.6944937833037, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=563, Percent_Identity=43.6944937833037, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=563, Percent_Identity=43.6944937833037, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=57.4349442379182, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=36.9458128078818, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322563, Length=570, Percent_Identity=41.4035087719298, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319432, Length=567, Percent_Identity=40.0352733686067, Blast_Score=416, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.5483870967742, Blast_Score=454, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=42.8571428571429, Blast_Score=388, Evalue=1e-108,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60489; Mature: 60358

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPMARYVFITGGVVSSLGKGIASAALGALLQARGYRVRLRKLDPYLNVDPGTMSPYQHG
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCC
EVFVTDDGAETDLDLGHYERFTGRSANKRDNITTGRIYQNIIEKERRGDYLGATVQVIPH
EEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
VTDEIKQFVLEGNEEFDFVLCEIGGTVGDIEAMPFLEAIRQLGNELPRGNAVYIHLTLMP
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
WIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADRPVPPEERRKLSLFCNVRESAVIQA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCEEEEEEECHHHHHHHH
LDVAHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMERWEEVSNRIHNPEGEVTIAIVGK
HHHHHHHHCCHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEC
YTGLKDAYKSLNEALTHGGIANRVRVKLDWIESEIFEKEDPAPWLEKVHGILVPGGFGER
CCCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCHHHHHHCCEEECCCCCCC
GSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGIEKASSTEFGPTKEPVVGLMT
CCCCCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
EWLRGNMLEKRTAAGDLGGTMRLGAYEARLQPGSKIAEIYGSEEISERHRHRYEVNIGYR
HHHHCCHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHCCHHHHHHHCCEEEEECCHH
EKLEACGLVFAGLSPDGVLPETIEYPDHPWFVGVQYHPELKSRPFEPHPLFASFIAAAVE
HHHHHHCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHH
QSRLV
HHCCC
>Mature Secondary Structure 
SPMARYVFITGGVVSSLGKGIASAALGALLQARGYRVRLRKLDPYLNVDPGTMSPYQHG
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCC
EVFVTDDGAETDLDLGHYERFTGRSANKRDNITTGRIYQNIIEKERRGDYLGATVQVIPH
EEEEECCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
VTDEIKQFVLEGNEEFDFVLCEIGGTVGDIEAMPFLEAIRQLGNELPRGNAVYIHLTLMP
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
WIPAAGELKTKPTQHSVKELRSIGIAPDILLVRADRPVPPEERRKLSLFCNVRESAVIQA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCEEEEEEECHHHHHHHH
LDVAHIYDVPMAYHKEGLDSEVLAAFGIDPAPKPRMERWEEVSNRIHNPEGEVTIAIVGK
HHHHHHHHCCHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEC
YTGLKDAYKSLNEALTHGGIANRVRVKLDWIESEIFEKEDPAPWLEKVHGILVPGGFGER
CCCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCHHHHHHCCEEECCCCCCC
GSEGKILAAKFARERKVPYFGICFGMQMACIEAARSLAGIEKASSTEFGPTKEPVVGLMT
CCCCCEEHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
EWLRGNMLEKRTAAGDLGGTMRLGAYEARLQPGSKIAEIYGSEEISERHRHRYEVNIGYR
HHHHCCHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHCCHHHHHHHCCEEEEECCHH
EKLEACGLVFAGLSPDGVLPETIEYPDHPWFVGVQYHPELKSRPFEPHPLFASFIAAAVE
HHHHHHCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHCCCCCCCHHHHHHHHHHHH
QSRLV
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA