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The map label for this gene is moaA [H]

Identifier: 110633911

GI number: 110633911

Start: 1676364

End: 1677368

Strand: Direct

Name: moaA [H]

Synonym: Meso_1558

Alternate gene names: 110633911

Gene position: 1676364-1677368 (Clockwise)

Preceding gene: 110633908

Following gene: 110633912

Centisome position: 37.99

GC content: 58.31

Gene sequence:

>1005_bases
ATGAACCTGAGCAGCATGATCGATCCTTTTGGCCGGGCTATTACTTATCTGCGTGTCTCGGTGACGGACCGCTGCGATTT
CCGCTGTGTCTATTGCATGGCGGAAGATATGCATTTCCTTCCCAAGAAGGATCTCTTGAGCTTGGAGGAGCTCGATCGGC
TCTGCACCGTCTTCATCGAGAAGGGTGTCCGGCGCTTGCGGCTCACGGGCGGCGAGCCCCTGGTGCGCAAGAATATCATG
CATCTTATGCGTCAGCTTTCGCGTCATCTCAAGTCGGGCGCTCTTGAGGAGCTGACACTTACGACAAACGGCTCGCAGCT
TGAGCGTTTCGCCGCCGAACTTTCCGATTGCGGCGTCAAGCGGGTCAATGTTTCGCTGGATACTCTCGATCCGGAAAAGT
TCCGCGCGATCACGCGCTGGGGCGTTCTTGACCGCGTTGGTCGGGGGATCGATGCCGCGCAGGCAGCAGGTCTCAAGATA
AAGATCAATACCGTCGCCCTCCGCGGCTTCAATGAGGCGGAAATACCCGAAATCATGCGCTGGGCCCATGGACGGAACAT
GGACATGACCGTCATCGAGACGATGCCGCTTGGCGAGGTGGATGTCGACCGCACGGATCAATACCTGCCGCTTTCGGAAC
TTCGCGCTGGCCTTGAGCGTCAATTCACCCTTACCGATATACCCTATAAGACCGGCGGCCCCGCTCGCTATGTCTCGGTG
TCGGAAACCGGCGGGAGACTGGGCTTTATCACGCCGCTCACCCATAATTTCTGCGAGAGCTGTAACCGTGTGCGCGTCAC
CTGTACCGGCACGCTCTATATGTGCCTTGGACAGGAGGATGCTGCCGATCTGCGAACACCCCTACGCACCTCGGAGGGAA
ACGAACTTCTCTCACGCGCCATCGACGAAGCGATCACCCGCAAACCAAAGGGCCACGATTTCGTCATTGATCGGCGCACC
CGCCGTCCCGCCGTTTCACGCCACATGAGTGTAACAGGCGGCTGA

Upstream 100 bases:

>100_bases
AAGATCAGATCGAAATCATTGCGGGGTATAAGCGGAGGATGCTAGCCTTGCTTGAAAAACGACGCTCCCGATCCGAAGTG
GGATCGTGGAGGAGGACTGA

Downstream 100 bases:

>100_bases
CAATCATTTTCGCTAATCTGGACCGATTGCTTTCGGCAGCTATCGGTCATAAGCGATACTTACGAGTCTTCCTTTCGGAG
CCAAAGTGGCCCTTAACGCA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNLSSMIDPFGRAITYLRVSVTDRCDFRCVYCMAEDMHFLPKKDLLSLEELDRLCTVFIEKGVRRLRLTGGEPLVRKNIM
HLMRQLSRHLKSGALEELTLTTNGSQLERFAAELSDCGVKRVNVSLDTLDPEKFRAITRWGVLDRVGRGIDAAQAAGLKI
KINTVALRGFNEAEIPEIMRWAHGRNMDMTVIETMPLGEVDVDRTDQYLPLSELRAGLERQFTLTDIPYKTGGPARYVSV
SETGGRLGFITPLTHNFCESCNRVRVTCTGTLYMCLGQEDAADLRTPLRTSEGNELLSRAIDEAITRKPKGHDFVIDRRT
RRPAVSRHMSVTGG

Sequences:

>Translated_334_residues
MNLSSMIDPFGRAITYLRVSVTDRCDFRCVYCMAEDMHFLPKKDLLSLEELDRLCTVFIEKGVRRLRLTGGEPLVRKNIM
HLMRQLSRHLKSGALEELTLTTNGSQLERFAAELSDCGVKRVNVSLDTLDPEKFRAITRWGVLDRVGRGIDAAQAAGLKI
KINTVALRGFNEAEIPEIMRWAHGRNMDMTVIETMPLGEVDVDRTDQYLPLSELRAGLERQFTLTDIPYKTGGPARYVSV
SETGGRLGFITPLTHNFCESCNRVRVTCTGTLYMCLGQEDAADLRTPLRTSEGNELLSRAIDEAITRKPKGHDFVIDRRT
RRPAVSRHMSVTGG
>Mature_334_residues
MNLSSMIDPFGRAITYLRVSVTDRCDFRCVYCMAEDMHFLPKKDLLSLEELDRLCTVFIEKGVRRLRLTGGEPLVRKNIM
HLMRQLSRHLKSGALEELTLTTNGSQLERFAAELSDCGVKRVNVSLDTLDPEKFRAITRWGVLDRVGRGIDAAQAAGLKI
KINTVALRGFNEAEIPEIMRWAHGRNMDMTVIETMPLGEVDVDRTDQYLPLSELRAGLERQFTLTDIPYKTGGPARYVSV
SETGGRLGFITPLTHNFCESCNRVRVTCTGTLYMCLGQEDAADLRTPLRTSEGNELLSRAIDEAITRKPKGHDFVIDRRT
RRPAVSRHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=34.2507645259939, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=34.2507645259939, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1786999, Length=334, Percent_Identity=32.6347305389222, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32566331, Length=334, Percent_Identity=35.6287425149701, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=36.1022364217252, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=313, Percent_Identity=35.4632587859425, Blast_Score=203, Evalue=8e-53,
Organism=Drosophila melanogaster, GI28574490, Length=313, Percent_Identity=38.3386581469649, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI28574488, Length=313, Percent_Identity=38.3386581469649, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37578; Mature: 37578

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSSMIDPFGRAITYLRVSVTDRCDFRCVYCMAEDMHFLPKKDLLSLEELDRLCTVFIE
CCHHHHHHHHHHHEEEEEEEECCCCCCEEEEEEHHHHHCCCCHHCCCHHHHHHHHHHHHH
KGVRRLRLTGGEPLVRKNIMHLMRQLSRHLKSGALEELTLTTNGSQLERFAAELSDCGVK
HCHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCE
RVNVSLDTLDPEKFRAITRWGVLDRVGRGIDAAQAAGLKIKINTVALRGFNEAEIPEIMR
EEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEEEEEEECCCCCHHHHHHH
WAHGRNMDMTVIETMPLGEVDVDRTDQYLPLSELRAGLERQFTLTDIPYKTGGPARYVSV
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCHHCEEEEEECCCCCCCCEEEEEE
SETGGRLGFITPLTHNFCESCNRVRVTCTGTLYMCLGQEDAADLRTPLRTSEGNELLSRA
ECCCCCEEEECHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHCCCCCCCCHHHHHHH
IDEAITRKPKGHDFVIDRRTRRPAVSRHMSVTGG
HHHHHHCCCCCCCEEEECCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MNLSSMIDPFGRAITYLRVSVTDRCDFRCVYCMAEDMHFLPKKDLLSLEELDRLCTVFIE
CCHHHHHHHHHHHEEEEEEEECCCCCCEEEEEEHHHHHCCCCHHCCCHHHHHHHHHHHHH
KGVRRLRLTGGEPLVRKNIMHLMRQLSRHLKSGALEELTLTTNGSQLERFAAELSDCGVK
HCHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCE
RVNVSLDTLDPEKFRAITRWGVLDRVGRGIDAAQAAGLKIKINTVALRGFNEAEIPEIMR
EEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEEEEEEECCCCCHHHHHHH
WAHGRNMDMTVIETMPLGEVDVDRTDQYLPLSELRAGLERQFTLTDIPYKTGGPARYVSV
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHCHHCEEEEEECCCCCCCCEEEEEE
SETGGRLGFITPLTHNFCESCNRVRVTCTGTLYMCLGQEDAADLRTPLRTSEGNELLSRA
ECCCCCEEEECHHHHHHHHCCCCEEEEEEEEEEEEECCCCHHHHHCCCCCCCCHHHHHHH
IDEAITRKPKGHDFVIDRRTRRPAVSRHMSVTGG
HHHHHHCCCCCCCEEEECCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]