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The map label for this gene is pleC [H]

Identifier: 110633906

GI number: 110633906

Start: 1670690

End: 1672207

Strand: Reverse

Name: pleC [H]

Synonym: Meso_1553

Alternate gene names: 110633906

Gene position: 1672207-1670690 (Counterclockwise)

Preceding gene: 110633909

Following gene: 110633904

Centisome position: 37.9

GC content: 57.05

Gene sequence:

>1518_bases
ATGGTGTTGAATCAAAACCAAATGGCGGACAAGTTCATAGTGAACCGCACGAAACCGCATCGCAACAGCGACGTGGCAAA
GGCTGTTCGGCACACGCGCGACCAGCTCTCGCGGAAGGCTGGTAATCGCTCCTTCGACAGGGAAATGCTGAAGATCCATG
CGCGCACGATCATCAGCAGCGCACCTGCGGTTCTCTTCGTCCTGCTGCTGATCGGCGCCGCCGGCTACGCGGTGGGCCCC
GCGCGCGAAATGGCCATCTGGGGAATGCTGGCGGCGGCAGGCTATACAGCGCTTTATCTTTTCGCGCGGTATATCGACAA
GCGATCCATCGACCAGATCGATGCGCGCAAGGTGCACGTTCAATTCCTGCTTTTGCATTTTTTCAGCGGCATCAGCTGGA
TCTATCTCGTATCGTTCGAGTGTCGTTGCGGCTTCCTGAATTTCTCGTTTTTCGTAGCGATTGTACTTCTGATGATGATT
GCAGCCACGGCGCTTGTTTGCTCCTCCCTGCGCGGCGCCGTCCTCGCCACTTTTGGCCTGCCAGTTGCCATACATGCACT
GCTGCATCTGGAATTTCCCTTGGGCGTAGAACCAGTTATGACGCTGTTGCTGGTTCTGTCCCTCCCATTTTTCGGGCATG
TTGCGCATCATCGCAACCAGGCGGCCATCAGCCTCCTAAGCTTCCGTAGCGAGAATGAATCCCTCATCGCAGAACTGGAG
ACGGCGAAGGCTGTATCCGACGAGGCGCGCCACCGTGCGGAAGAGGCCAATTTGGCGAAGTCCCGCTTCCTCGCTTCGAT
GAGCCACGAATTGCGGACGCCGCTCAACGCAATCCTCGGGTTTTCGGAGGTCATGGCGAAGGAAGTGCTCGGCCCCGTCC
AGAACGTGACTTATCGGGAATACGCCAAGGATGTCCATCAATCGGGACAACATCTGCTCGAACTGATCAACGAGATTCTC
GACCTTTCCCGCATTGAGGCCGGACGCTACCAGCTCAACGAGGAGCCGCTTGCGCTTGCCGACATTGTCCATGAATGCTG
CCGGATGATGGATCTCAAGCTGAAGGCGAAGGATATAAAGCTTGTCCAGCAGTTCGAACCTTCGCTGCTGAACCTTATGG
CCGACGAGCGGGCGGTGCGGCAGATTTCGCTCAATCTGCTTTCGAATGCGGTGAAGTTCACGCCGTCCGGAGGGGAAATC
CGCGTTCGGGTCGGCTGGACGTCCGGAGGTGGCCAGTACATTTCAATCTGCGACAACGGCCCCGGAATTTCGGAAGAAGA
GATGCCGCTTGTCCTTTCCGCCTTTGGTCAAGGTTCCGTTGCGATCAAGAGTGCGGAACAGGGAACCGGACTGGGACTGC
CAATCGTCCAGGGTTTGACACATCTGCACGGAGGGCTATTGCGTTTGAAATCAAAGCTGCGGGAAGGAACCGTCGCAACT
GTGATCTTTCCACGAAGTCGTGTGGTCGAGGAAGCCGTCGCGCCGCCAGTCCGCCAAAAAAAGCGTGCCGTTGGCTGA

Upstream 100 bases:

>100_bases
TACTACGCCAATAATTTCTACGACTTACACGCATTAACTGAAGGGTCTCTTAATTATTCGCCGGTATTTATGGAACCATG
CCGGAAATGCGACGCGTCCG

Downstream 100 bases:

>100_bases
AGTTTCAGGCGCGCAGCCGCGCGTTCACCTCCGCCCTCCGCGCCGAGATTTCACTCGCTCCCCGGACCACCCCTGCGGCA
AGAGCGCCCGCGACACCGCC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MVLNQNQMADKFIVNRTKPHRNSDVAKAVRHTRDQLSRKAGNRSFDREMLKIHARTIISSAPAVLFVLLLIGAAGYAVGP
AREMAIWGMLAAAGYTALYLFARYIDKRSIDQIDARKVHVQFLLLHFFSGISWIYLVSFECRCGFLNFSFFVAIVLLMMI
AATALVCSSLRGAVLATFGLPVAIHALLHLEFPLGVEPVMTLLLVLSLPFFGHVAHHRNQAAISLLSFRSENESLIAELE
TAKAVSDEARHRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMAKEVLGPVQNVTYREYAKDVHQSGQHLLELINEIL
DLSRIEAGRYQLNEEPLALADIVHECCRMMDLKLKAKDIKLVQQFEPSLLNLMADERAVRQISLNLLSNAVKFTPSGGEI
RVRVGWTSGGGQYISICDNGPGISEEEMPLVLSAFGQGSVAIKSAEQGTGLGLPIVQGLTHLHGGLLRLKSKLREGTVAT
VIFPRSRVVEEAVAPPVRQKKRAVG

Sequences:

>Translated_505_residues
MVLNQNQMADKFIVNRTKPHRNSDVAKAVRHTRDQLSRKAGNRSFDREMLKIHARTIISSAPAVLFVLLLIGAAGYAVGP
AREMAIWGMLAAAGYTALYLFARYIDKRSIDQIDARKVHVQFLLLHFFSGISWIYLVSFECRCGFLNFSFFVAIVLLMMI
AATALVCSSLRGAVLATFGLPVAIHALLHLEFPLGVEPVMTLLLVLSLPFFGHVAHHRNQAAISLLSFRSENESLIAELE
TAKAVSDEARHRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMAKEVLGPVQNVTYREYAKDVHQSGQHLLELINEIL
DLSRIEAGRYQLNEEPLALADIVHECCRMMDLKLKAKDIKLVQQFEPSLLNLMADERAVRQISLNLLSNAVKFTPSGGEI
RVRVGWTSGGGQYISICDNGPGISEEEMPLVLSAFGQGSVAIKSAEQGTGLGLPIVQGLTHLHGGLLRLKSKLREGTVAT
VIFPRSRVVEEAVAPPVRQKKRAVG
>Mature_505_residues
MVLNQNQMADKFIVNRTKPHRNSDVAKAVRHTRDQLSRKAGNRSFDREMLKIHARTIISSAPAVLFVLLLIGAAGYAVGP
AREMAIWGMLAAAGYTALYLFARYIDKRSIDQIDARKVHVQFLLLHFFSGISWIYLVSFECRCGFLNFSFFVAIVLLMMI
AATALVCSSLRGAVLATFGLPVAIHALLHLEFPLGVEPVMTLLLVLSLPFFGHVAHHRNQAAISLLSFRSENESLIAELE
TAKAVSDEARHRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMAKEVLGPVQNVTYREYAKDVHQSGQHLLELINEIL
DLSRIEAGRYQLNEEPLALADIVHECCRMMDLKLKAKDIKLVQQFEPSLLNLMADERAVRQISLNLLSNAVKFTPSGGEI
RVRVGWTSGGGQYISICDNGPGISEEEMPLVLSAFGQGSVAIKSAEQGTGLGLPIVQGLTHLHGGLLRLKSKLREGTVAT
VIFPRSRVVEEAVAPPVRQKKRAVG

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=275, Percent_Identity=32.7272727272727, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1788713, Length=259, Percent_Identity=35.1351351351351, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87081816, Length=294, Percent_Identity=34.3537414965986, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI48994928, Length=257, Percent_Identity=29.9610894941634, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=27.2357723577236, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI145693157, Length=268, Percent_Identity=30.9701492537313, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=30.4721030042918, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=26.8595041322314, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=23.9837398373984, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=24.4897959183673, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790300, Length=246, Percent_Identity=24.390243902439, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=24.3346007604563, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=232, Percent_Identity=27.1551724137931, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=25.9615384615385, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=148, Percent_Identity=33.1081081081081, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55644; Mature: 55644

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLNQNQMADKFIVNRTKPHRNSDVAKAVRHTRDQLSRKAGNRSFDREMLKIHARTIISS
CCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
APAVLFVLLLIGAAGYAVGPAREMAIWGMLAAAGYTALYLFARYIDKRSIDQIDARKVHV
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QFLLLHFFSGISWIYLVSFECRCGFLNFSFFVAIVLLMMIAATALVCSSLRGAVLATFGL
HHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVAIHALLHLEFPLGVEPVMTLLLVLSLPFFGHVAHHRNQAAISLLSFRSENESLIAELE
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHH
TAKAVSDEARHRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMAKEVLGPVQNVTYRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
YAKDVHQSGQHLLELINEILDLSRIEAGRYQLNEEPLALADIVHECCRMMDLKLKAKDIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LVQQFEPSLLNLMADERAVRQISLNLLSNAVKFTPSGGEIRVRVGWTSGGGQYISICDNG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCEEEEECCC
PGISEEEMPLVLSAFGQGSVAIKSAEQGTGLGLPIVQGLTHLHGGLLRLKSKLREGTVAT
CCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
VIFPRSRVVEEAVAPPVRQKKRAVG
EEECHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure
MVLNQNQMADKFIVNRTKPHRNSDVAKAVRHTRDQLSRKAGNRSFDREMLKIHARTIISS
CCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
APAVLFVLLLIGAAGYAVGPAREMAIWGMLAAAGYTALYLFARYIDKRSIDQIDARKVHV
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QFLLLHFFSGISWIYLVSFECRCGFLNFSFFVAIVLLMMIAATALVCSSLRGAVLATFGL
HHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVAIHALLHLEFPLGVEPVMTLLLVLSLPFFGHVAHHRNQAAISLLSFRSENESLIAELE
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHH
TAKAVSDEARHRAEEANLAKSRFLASMSHELRTPLNAILGFSEVMAKEVLGPVQNVTYRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
YAKDVHQSGQHLLELINEILDLSRIEAGRYQLNEEPLALADIVHECCRMMDLKLKAKDIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LVQQFEPSLLNLMADERAVRQISLNLLSNAVKFTPSGGEIRVRVGWTSGGGQYISICDNG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCEEEEECCC
PGISEEEMPLVLSAFGQGSVAIKSAEQGTGLGLPIVQGLTHLHGGLLRLKSKLREGTVAT
CCCCCCCCCHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
VIFPRSRVVEEAVAPPVRQKKRAVG
EEECHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]