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The map label for this gene is ywrD [H]

Identifier: 110633862

GI number: 110633862

Start: 1607312

End: 1608916

Strand: Direct

Name: ywrD [H]

Synonym: Meso_1509

Alternate gene names: 110633862

Gene position: 1607312-1608916 (Clockwise)

Preceding gene: 110633861

Following gene: 110633863

Centisome position: 36.43

GC content: 62.49

Gene sequence:

>1605_bases
ATGATCAGCGACACCATCATAGAGCGGGATTTCATGCGACCTGGCAAATCGGTCGCGCTGGCTGGAACGGCGATGATCGC
TACGTCGCACCCGCAGGCGACCATGGCAGGCCTGAAAATCCTTGAAGCTGGCGGCAACGCTGTCGATGCGGCAATTGCCG
CTGTTGCGCTTCAGGGTGTTATCGATCCTCATATGACCGGTATCGGCGGCGACTGTTTCGCACTCTACGCCGCAGCCGGG
AAAGCGCCCATCGCCATCAACGGTTCCGGCCGAGCGCCTGCAGCCGCAACACTGGACCATTTCGAAGGCCTCGGCCTAGA
CAAGATTCCGGACGGTTCGGTTCACGCCGTCACCGTCCCCGGCGCGGTCGATGCCTGGTGCAAGCTCAGCGAACGATACG
GCAAGCTTGGGCTTGAGGCGATCCTCCAGCCCGCGATCGATGCCACCCGCGACGGCTTCGTCGTCATGCCGCGGGTCGCT
CACGATTGGGCGCGATATGCCGACCGCCTGCGGCCATACCCGGCGTCGGTTAAGCAGTATTTGCCTGGCAATAAGGCGCC
CGCCGTCGGTGACCGCCTGAACCATCCTGCCCTGGGGGAAACCCTGAAACGTATCGCCAGGGAAGGTCGCACGGCATTTT
ACGAAGGCGAGGTCGCGCAGGACATGGTGTCGATGCTGCAAAGCCTCGGCGGTCTTCATACGCTGGAGGATTTCGCATCC
TACGCGGCGTTCGAAACCGCGCCGATCTCCGCATCCTATCGTGGCTACGACCTCGTTGAGTGCCCACCGAATGGACAGGG
CCTGGCGGCGCTTGTGATCGCGCGCATTCTCGACGGCTTCGATCTCGCCGCGCCGGATCTCTCGGAAGCCGATCGCATTC
ACCTGTTCGCGGAAGCAACCAAGGCGGCCTATCGCCTGCGCGACATATATGTCGCCGACCCCGAGTATATGCGGCACTCC
GCTGAGGAACTGCTGTCCGACGCCTTCATTGCCTCTTTGCGCAACAAGATCGACATGACGAAGGCGAGCGCCGTCGAAGA
TTTCGACATCCCCCTTCACCGCGATACGGTCTATGTGACGGTGGTCGACGCCGACGGCAACGCCATCTCGTTGATCAACT
CGCTCTTTTTTGCCTTCGGCAGCGGCATCTATGCGCCGAAGGCCGGCGTGCTGCTGCAAAATCGCGGCGCGGGCTTCTCA
CTGAAGCGGGGACACCCGAACGCTATCGGCCCCGGCAAGCTGCCGTTTCATACCATCATCCCGGCGATGGTGCTGCGTGA
CGGAAAGCCTATCATGTCTTACGGCGTGATGGGCGGGCAGTATCAGGCGGTGGGCCACGTACACATCCTGTCGCAGATCG
TTGACCACGGCCTTGACGTGCAGATGGCAAGCGACCAGCCGCGCTCGTTCTTTACCGATGGCGCCATCTCCCTCGAGGTG
ACCATTTCGGCGGACGTCCGGGCCGAACTGGAAAGGCGGGGCCACAAGACGCGCTGGGCGGACGAACCACTTGGCGGCTG
CCAGGCGATCTGGATCGACCGCGAGCGCGGCATTCTGTGGGGCGCGTCTGACCACCGGAAAGACGGGGTTGCACTGGGTT
ATTGA

Upstream 100 bases:

>100_bases
GTCCAGTCGGTTCCGACTGTCCGGCGTCCTACCTGCAACTCCACAACCATGTGACTGTGATCTGCGACAGCGCAGCCGCT
GCTCACCTCGAGGAGCCATA

Downstream 100 bases:

>100_bases
CCATGGACAAGCGTACAGTCGTATCGATCCGGAATCTGAGCCTCCGGTTGCCCGCCGGGGCCGATCGCGAATTCGCGCTG
AAGGAGATGAACCTCGATCT

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MISDTIIERDFMRPGKSVALAGTAMIATSHPQATMAGLKILEAGGNAVDAAIAAVALQGVIDPHMTGIGGDCFALYAAAG
KAPIAINGSGRAPAAATLDHFEGLGLDKIPDGSVHAVTVPGAVDAWCKLSERYGKLGLEAILQPAIDATRDGFVVMPRVA
HDWARYADRLRPYPASVKQYLPGNKAPAVGDRLNHPALGETLKRIAREGRTAFYEGEVAQDMVSMLQSLGGLHTLEDFAS
YAAFETAPISASYRGYDLVECPPNGQGLAALVIARILDGFDLAAPDLSEADRIHLFAEATKAAYRLRDIYVADPEYMRHS
AEELLSDAFIASLRNKIDMTKASAVEDFDIPLHRDTVYVTVVDADGNAISLINSLFFAFGSGIYAPKAGVLLQNRGAGFS
LKRGHPNAIGPGKLPFHTIIPAMVLRDGKPIMSYGVMGGQYQAVGHVHILSQIVDHGLDVQMASDQPRSFFTDGAISLEV
TISADVRAELERRGHKTRWADEPLGGCQAIWIDRERGILWGASDHRKDGVALGY

Sequences:

>Translated_534_residues
MISDTIIERDFMRPGKSVALAGTAMIATSHPQATMAGLKILEAGGNAVDAAIAAVALQGVIDPHMTGIGGDCFALYAAAG
KAPIAINGSGRAPAAATLDHFEGLGLDKIPDGSVHAVTVPGAVDAWCKLSERYGKLGLEAILQPAIDATRDGFVVMPRVA
HDWARYADRLRPYPASVKQYLPGNKAPAVGDRLNHPALGETLKRIAREGRTAFYEGEVAQDMVSMLQSLGGLHTLEDFAS
YAAFETAPISASYRGYDLVECPPNGQGLAALVIARILDGFDLAAPDLSEADRIHLFAEATKAAYRLRDIYVADPEYMRHS
AEELLSDAFIASLRNKIDMTKASAVEDFDIPLHRDTVYVTVVDADGNAISLINSLFFAFGSGIYAPKAGVLLQNRGAGFS
LKRGHPNAIGPGKLPFHTIIPAMVLRDGKPIMSYGVMGGQYQAVGHVHILSQIVDHGLDVQMASDQPRSFFTDGAISLEV
TISADVRAELERRGHKTRWADEPLGGCQAIWIDRERGILWGASDHRKDGVALGY
>Mature_534_residues
MISDTIIERDFMRPGKSVALAGTAMIATSHPQATMAGLKILEAGGNAVDAAIAAVALQGVIDPHMTGIGGDCFALYAAAG
KAPIAINGSGRAPAAATLDHFEGLGLDKIPDGSVHAVTVPGAVDAWCKLSERYGKLGLEAILQPAIDATRDGFVVMPRVA
HDWARYADRLRPYPASVKQYLPGNKAPAVGDRLNHPALGETLKRIAREGRTAFYEGEVAQDMVSMLQSLGGLHTLEDFAS
YAAFETAPISASYRGYDLVECPPNGQGLAALVIARILDGFDLAAPDLSEADRIHLFAEATKAAYRLRDIYVADPEYMRHS
AEELLSDAFIASLRNKIDMTKASAVEDFDIPLHRDTVYVTVVDADGNAISLINSLFFAFGSGIYAPKAGVLLQNRGAGFS
LKRGHPNAIGPGKLPFHTIIPAMVLRDGKPIMSYGVMGGQYQAVGHVHILSQIVDHGLDVQMASDQPRSFFTDGAISLEV
TISADVRAELERRGHKTRWADEPLGGCQAIWIDRERGILWGASDHRKDGVALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=537, Percent_Identity=29.4227188081937, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI73915090, Length=537, Percent_Identity=29.4227188081937, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI73915096, Length=537, Percent_Identity=29.4227188081937, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI73915094, Length=537, Percent_Identity=29.4227188081937, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI113429324, Length=536, Percent_Identity=28.9179104477612, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI113429326, Length=541, Percent_Identity=28.4658040665434, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI153266885, Length=542, Percent_Identity=24.7232472324723, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI153266901, Length=543, Percent_Identity=24.8618784530387, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI109148539, Length=511, Percent_Identity=27.9843444227006, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI153266907, Length=538, Percent_Identity=23.6059479553903, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI30581157, Length=227, Percent_Identity=30.8370044052863, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI30581155, Length=227, Percent_Identity=30.8370044052863, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789856, Length=552, Percent_Identity=33.3333333333333, Blast_Score=257, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17506189, Length=498, Percent_Identity=27.710843373494, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI72000294, Length=453, Percent_Identity=25.8278145695364, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=453, Percent_Identity=25.8278145695364, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17542894, Length=551, Percent_Identity=26.1343012704174, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193208245, Length=517, Percent_Identity=25.531914893617, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193208247, Length=517, Percent_Identity=25.531914893617, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323330, Length=439, Percent_Identity=24.1457858769932, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642670, Length=548, Percent_Identity=26.6423357664234, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24642666, Length=548, Percent_Identity=26.6423357664234, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI161077878, Length=548, Percent_Identity=26.6423357664234, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45551474, Length=548, Percent_Identity=26.6423357664234, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI161077880, Length=548, Percent_Identity=26.6423357664234, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI18859893, Length=502, Percent_Identity=27.0916334661355, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161077496, Length=410, Percent_Identity=27.8048780487805, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18859741, Length=547, Percent_Identity=24.3144424131627, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57107; Mature: 57107

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDTIIERDFMRPGKSVALAGTAMIATSHPQATMAGLKILEAGGNAVDAAIAAVALQGV
CCCCHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHHHHC
IDPHMTGIGGDCFALYAAAGKAPIAINGSGRAPAAATLDHFEGLGLDKIPDGSVHAVTVP
CCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECC
GAVDAWCKLSERYGKLGLEAILQPAIDATRDGFVVMPRVAHDWARYADRLRPYPASVKQY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHH
LPGNKAPAVGDRLNHPALGETLKRIAREGRTAFYEGEVAQDMVSMLQSLGGLHTLEDFAS
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHH
YAAFETAPISASYRGYDLVECPPNGQGLAALVIARILDGFDLAAPDLSEADRIHLFAEAT
HHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHH
KAAYRLRDIYVADPEYMRHSAEELLSDAFIASLRNKIDMTKASAVEDFDIPLHRDTVYVT
HHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCEEEEE
VVDADGNAISLINSLFFAFGSGIYAPKAGVLLQNRGAGFSLKRGHPNAIGPGKLPFHTII
EEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHH
PAMVLRDGKPIMSYGVMGGQYQAVGHVHILSQIVDHGLDVQMASDQPRSFFTDGAISLEV
HHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHCCCCCEEEEE
TISADVRAELERRGHKTRWADEPLGGCQAIWIDRERGILWGASDHRKDGVALGY
EEECHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MISDTIIERDFMRPGKSVALAGTAMIATSHPQATMAGLKILEAGGNAVDAAIAAVALQGV
CCCCHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHEECCCCHHHHHHHHHHHHHC
IDPHMTGIGGDCFALYAAAGKAPIAINGSGRAPAAATLDHFEGLGLDKIPDGSVHAVTVP
CCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEECC
GAVDAWCKLSERYGKLGLEAILQPAIDATRDGFVVMPRVAHDWARYADRLRPYPASVKQY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHH
LPGNKAPAVGDRLNHPALGETLKRIAREGRTAFYEGEVAQDMVSMLQSLGGLHTLEDFAS
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHH
YAAFETAPISASYRGYDLVECPPNGQGLAALVIARILDGFDLAAPDLSEADRIHLFAEAT
HHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHH
KAAYRLRDIYVADPEYMRHSAEELLSDAFIASLRNKIDMTKASAVEDFDIPLHRDTVYVT
HHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCEEEEE
VVDADGNAISLINSLFFAFGSGIYAPKAGVLLQNRGAGFSLKRGHPNAIGPGKLPFHTII
EEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHH
PAMVLRDGKPIMSYGVMGGQYQAVGHVHILSQIVDHGLDVQMASDQPRSFFTDGAISLEV
HHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHCCCCCEEEEE
TISADVRAELERRGHKTRWADEPLGGCQAIWIDRERGILWGASDHRKDGVALGY
EEECHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]