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The map label for this gene is nagB [H]

Identifier: 110633861

GI number: 110633861

Start: 1606554

End: 1607312

Strand: Direct

Name: nagB [H]

Synonym: Meso_1508

Alternate gene names: 110633861

Gene position: 1606554-1607312 (Clockwise)

Preceding gene: 110633860

Following gene: 110633862

Centisome position: 36.41

GC content: 60.34

Gene sequence:

>759_bases
ATGACGGCGCAATTGCTAGCCAAGGCTGAAAATACCAGAGCGGTGGAGATCATCCGCTTCAATACCGCCGCGCAGGCCGA
ACGAGCAGCGGCAGCGGTGCTGCGGCGCCATATCACGCAAACTGCCAATTCAGTTCTGGGGCTGGCGACGGGGCGGACGA
TGCTGCCTGTCTATGCTTGGCTTCGCCAGTGGCATAGGGAAGGCGAGCTGTCATTCGCCCAAAGCACCAGCTTCAACCTC
GATGAATATTGCGGCCTTGCATCCGACGATCCGTCGAGTTTCGTCAGCTATATGCGGCGCAATCTTTTCGACCATGTCGA
CATGGCAAAAGGGCGCTTCCATTTTCCCGACCAGACCCATCCGGAGGCTTTCGACGCACGCATCCGCGACAGCGGCGGCA
TCGGCCTGCAACTGCTGGGCATCGGCCGCAACGGCCATATCGGGTTCAACGAGCCCGGCGCCGACAGGAAAAGCCGCACT
CATATCGTGACGCTGTCGGAATCCACCCGTAAGGCGAATGCCGGTGACTTCCCGGCTGGAACGCCGGTCCCGAAACAGGC
CGTGACGATGGGAATCGCGACTATTCTGGAAGCCGAGCGGATCGTTCTGCTTGCTACAGGAAGCGGAAAGGCGGACATTC
TCAGGCGGGCGTTCCAAGGTCCAGTCGGTTCCGACTGTCCGGCGTCCTACCTGCAACTCCACAACCATGTGACTGTGATC
TGCGACAGCGCAGCCGCTGCTCACCTCGAGGAGCCATAA

Upstream 100 bases:

>100_bases
CGCTGGGCCGTCGCGCTGGTCTGCTGGGTACGATCAGCCAGAGCCGCGACCTGCTGCGCGCGATGCTGCTGACCACGGAA
CCGTCGAAAGTGGGGCGGCC

Downstream 100 bases:

>100_bases
TGATCAGCGACACCATCATAGAGCGGGATTTCATGCGACCTGGCAAATCGGTCGCGCTGGCTGGAACGGCGATGATCGCT
ACGTCGCACCCGCAGGCGAC

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTAQLLAKAENTRAVEIIRFNTAAQAERAAAAVLRRHITQTANSVLGLATGRTMLPVYAWLRQWHREGELSFAQSTSFNL
DEYCGLASDDPSSFVSYMRRNLFDHVDMAKGRFHFPDQTHPEAFDARIRDSGGIGLQLLGIGRNGHIGFNEPGADRKSRT
HIVTLSESTRKANAGDFPAGTPVPKQAVTMGIATILEAERIVLLATGSGKADILRRAFQGPVGSDCPASYLQLHNHVTVI
CDSAAAAHLEEP

Sequences:

>Translated_252_residues
MTAQLLAKAENTRAVEIIRFNTAAQAERAAAAVLRRHITQTANSVLGLATGRTMLPVYAWLRQWHREGELSFAQSTSFNL
DEYCGLASDDPSSFVSYMRRNLFDHVDMAKGRFHFPDQTHPEAFDARIRDSGGIGLQLLGIGRNGHIGFNEPGADRKSRT
HIVTLSESTRKANAGDFPAGTPVPKQAVTMGIATILEAERIVLLATGSGKADILRRAFQGPVGSDCPASYLQLHNHVTVI
CDSAAAAHLEEP
>Mature_251_residues
TAQLLAKAENTRAVEIIRFNTAAQAERAAAAVLRRHITQTANSVLGLATGRTMLPVYAWLRQWHREGELSFAQSTSFNLD
EYCGLASDDPSSFVSYMRRNLFDHVDMAKGRFHFPDQTHPEAFDARIRDSGGIGLQLLGIGRNGHIGFNEPGADRKSRTH
IVTLSESTRKANAGDFPAGTPVPKQAVTMGIATILEAERIVLLATGSGKADILRRAFQGPVGSDCPASYLQLHNHVTVIC
DSAAAAHLEEP

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=248, Percent_Identity=36.6935483870968, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI19923881, Length=244, Percent_Identity=37.2950819672131, Blast_Score=151, Evalue=4e-37,
Organism=Escherichia coli, GI1786893, Length=252, Percent_Identity=37.3015873015873, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1789530, Length=228, Percent_Identity=30.7017543859649, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI48994958, Length=227, Percent_Identity=26.431718061674, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17554876, Length=244, Percent_Identity=38.9344262295082, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24581960, Length=212, Percent_Identity=38.6792452830189, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19920764, Length=212, Percent_Identity=38.6792452830189, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 27362; Mature: 27231

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQLLAKAENTRAVEIIRFNTAAQAERAAAAVLRRHITQTANSVLGLATGRTMLPVYAW
CCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LRQWHREGELSFAQSTSFNLDEYCGLASDDPSSFVSYMRRNLFDHVDMAKGRFHFPDQTH
HHHHHHCCCCEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
PEAFDARIRDSGGIGLQLLGIGRNGHIGFNEPGADRKSRTHIVTLSESTRKANAGDFPAG
CHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
TPVPKQAVTMGIATILEAERIVLLATGSGKADILRRAFQGPVGSDCPASYLQLHNHVTVI
CCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHCCEEEE
CDSAAAAHLEEP
ECCHHHHCCCCC
>Mature Secondary Structure 
TAQLLAKAENTRAVEIIRFNTAAQAERAAAAVLRRHITQTANSVLGLATGRTMLPVYAW
CHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LRQWHREGELSFAQSTSFNLDEYCGLASDDPSSFVSYMRRNLFDHVDMAKGRFHFPDQTH
HHHHHHCCCCEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
PEAFDARIRDSGGIGLQLLGIGRNGHIGFNEPGADRKSRTHIVTLSESTRKANAGDFPAG
CHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
TPVPKQAVTMGIATILEAERIVLLATGSGKADILRRAFQGPVGSDCPASYLQLHNHVTVI
CCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHCCEEEE
CDSAAAAHLEEP
ECCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA