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The map label for this gene is cysK [H]

Identifier: 110633777

GI number: 110633777

Start: 1522158

End: 1523198

Strand: Direct

Name: cysK [H]

Synonym: Meso_1424

Alternate gene names: 110633777

Gene position: 1522158-1523198 (Clockwise)

Preceding gene: 110633776

Following gene: 110633779

Centisome position: 34.5

GC content: 61.48

Gene sequence:

>1041_bases
ATGTACCAGACCGTCATCGAAGCCATTGGCAATACGCCACTTATCCGCCTGAAACGGGCTTCCGAGGAGACCGGCTGCGA
GATCTATGGTAAGGCGGAGTTCATGAATCCCGGGCAGTCCGTGAAGGACCGGGCCGGGCTCTTCATCATTCGCGATGCCG
AGAAGCGTGGCCTGCTGCGGCCGGGCGGCGTGATCGTGGAGGGCACGGCCGGAAATACGGGGATTGGCCTTACCGTCGTC
GCCAAGGCCCTGGGCTATCGCACCGTAATCGTCATTCCCGATACGCAAAGCCAGGAGAAGAAGGATGCACTTCGCATCCT
CGGAGCGGAGCTGATCGAGGTGCCGGCTGTCCCGTACAAGAACCCCAACAATTACGTGAAGGTTTCGGGCCGCCTCGCCG
AACAGCTTGCCCGCACCGAGGCGAGCGGCGCCATCTGGGCCAACCAGTTTGACAATGTGGCGAACCGCGACGGCCACATC
CGCACCACAGCCGAAGAGATCTGGCGCCAGACGGGCGGCAAGGTGGACGGCTTCGTCTCCGCCGTTGGTACTGGCGGCAC
GCTTGCGGGCGTGTCGGCGGGCCTCAAGGCCAGGAACCCGGACGTCAAGGTGGCGCTGGCCGATCCGCTTGGCGCTGCCC
TTTTCAGCTACTACACCGCTGGCGAATTGAAATCGGAGGGGAGTTCGATCACCGAAGGAATCGGGCAGGGGCGCATCACG
GCGAATTTGGAAGATTTCCAGCCGGACTTTTCCTTTCAGATTCCCGATGAGGAGGCGCTGCCGATCATCTTTTCGCTCGT
GCAGGAAGAAGGGCTGTGCCTGGGCGGGTCGACCGGCATCAACATCGCTGGCGCGATTCGAATGGCAAGGGAACTGGGCC
CCGGCCACACGATCGTTACGATTCTGGCCGATTACGGCACGCGCTATCAGTCGAAGCTCTTCAATCCTGCCTTCCTGCGT
GAAAAGAAGCTTCCCGTTCCCGCCTGGATGGAAGGAAGATCGGAAATACCGGTGCCATTCGAACAGGTGGCGGCCAGCTA
A

Upstream 100 bases:

>100_bases
AAACAAGAACTTGCAACAGGGATGACCGGTTTTTAGGTTCGCAGGGCGACATACTGTCCGTGCACCAGTCGCCGTAGCCC
GTGACCAGCGAGGATCCGCC

Downstream 100 bases:

>100_bases
GCGCACCGGCCCGAAAACCGGAAACGGTTTTCGGAAAGAACGATGCGTAGATTCAATAACGTACGGTCGGCAGGTCCGCG
CAATCGCTAGGCGCGGGGCT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MYQTVIEAIGNTPLIRLKRASEETGCEIYGKAEFMNPGQSVKDRAGLFIIRDAEKRGLLRPGGVIVEGTAGNTGIGLTVV
AKALGYRTVIVIPDTQSQEKKDALRILGAELIEVPAVPYKNPNNYVKVSGRLAEQLARTEASGAIWANQFDNVANRDGHI
RTTAEEIWRQTGGKVDGFVSAVGTGGTLAGVSAGLKARNPDVKVALADPLGAALFSYYTAGELKSEGSSITEGIGQGRIT
ANLEDFQPDFSFQIPDEEALPIIFSLVQEEGLCLGGSTGINIAGAIRMARELGPGHTIVTILADYGTRYQSKLFNPAFLR
EKKLPVPAWMEGRSEIPVPFEQVAAS

Sequences:

>Translated_346_residues
MYQTVIEAIGNTPLIRLKRASEETGCEIYGKAEFMNPGQSVKDRAGLFIIRDAEKRGLLRPGGVIVEGTAGNTGIGLTVV
AKALGYRTVIVIPDTQSQEKKDALRILGAELIEVPAVPYKNPNNYVKVSGRLAEQLARTEASGAIWANQFDNVANRDGHI
RTTAEEIWRQTGGKVDGFVSAVGTGGTLAGVSAGLKARNPDVKVALADPLGAALFSYYTAGELKSEGSSITEGIGQGRIT
ANLEDFQPDFSFQIPDEEALPIIFSLVQEEGLCLGGSTGINIAGAIRMARELGPGHTIVTILADYGTRYQSKLFNPAFLR
EKKLPVPAWMEGRSEIPVPFEQVAAS
>Mature_346_residues
MYQTVIEAIGNTPLIRLKRASEETGCEIYGKAEFMNPGQSVKDRAGLFIIRDAEKRGLLRPGGVIVEGTAGNTGIGLTVV
AKALGYRTVIVIPDTQSQEKKDALRILGAELIEVPAVPYKNPNNYVKVSGRLAEQLARTEASGAIWANQFDNVANRDGHI
RTTAEEIWRQTGGKVDGFVSAVGTGGTLAGVSAGLKARNPDVKVALADPLGAALFSYYTAGELKSEGSSITEGIGQGRIT
ANLEDFQPDFSFQIPDEEALPIIFSLVQEEGLCLGGSTGINIAGAIRMARELGPGHTIVTILADYGTRYQSKLFNPAFLR
EKKLPVPAWMEGRSEIPVPFEQVAAS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=340, Percent_Identity=37.3529411764706, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI295821200, Length=340, Percent_Identity=37.3529411764706, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4557415, Length=340, Percent_Identity=37.3529411764706, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI11345492, Length=208, Percent_Identity=31.7307692307692, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI2367138, Length=315, Percent_Identity=37.7777777777778, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=38.4375, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535051, Length=313, Percent_Identity=36.741214057508, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32566674, Length=311, Percent_Identity=35.3697749196142, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562970, Length=311, Percent_Identity=35.3697749196142, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=38.0327868852459, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17561720, Length=323, Percent_Identity=34.6749226006192, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534315, Length=332, Percent_Identity=32.8313253012048, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=332, Percent_Identity=33.1325301204819, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32566672, Length=219, Percent_Identity=31.9634703196347, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=331, Percent_Identity=27.4924471299094, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=39.8791540785499, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321594, Length=334, Percent_Identity=31.7365269461078, Blast_Score=165, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24643623, Length=333, Percent_Identity=36.6366366366366, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI20129101, Length=333, Percent_Identity=36.6366366366366, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36990; Mature: 36990

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQTVIEAIGNTPLIRLKRASEETGCEIYGKAEFMNPGQSVKDRAGLFIIRDAEKRGLLR
CHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHCCEEEEEECCCCCCCC
PGGVIVEGTAGNTGIGLTVVAKALGYRTVIVIPDTQSQEKKDALRILGAELIEVPAVPYK
CCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
NPNNYVKVSGRLAEQLARTEASGAIWANQFDNVANRDGHIRTTAEEIWRQTGGKVDGFVS
CCCCEEEECHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCHHHE
AVGTGGTLAGVSAGLKARNPDVKVALADPLGAALFSYYTAGELKSEGSSITEGIGQGRIT
ECCCCCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCHHHCCCCHHHHHCCCCEEE
ANLEDFQPDFSFQIPDEEALPIIFSLVQEEGLCLGGSTGINIAGAIRMARELGPGHTIVT
ECHHHCCCCCEEECCCCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEE
ILADYGTRYQSKLFNPAFLREKKLPVPAWMEGRSEIPVPFEQVAAS
EEEHHCCHHHHHCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MYQTVIEAIGNTPLIRLKRASEETGCEIYGKAEFMNPGQSVKDRAGLFIIRDAEKRGLLR
CHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHCCEEEEEECCCCCCCC
PGGVIVEGTAGNTGIGLTVVAKALGYRTVIVIPDTQSQEKKDALRILGAELIEVPAVPYK
CCCEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCC
NPNNYVKVSGRLAEQLARTEASGAIWANQFDNVANRDGHIRTTAEEIWRQTGGKVDGFVS
CCCCEEEECHHHHHHHHHHCCCCCEEHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCHHHE
AVGTGGTLAGVSAGLKARNPDVKVALADPLGAALFSYYTAGELKSEGSSITEGIGQGRIT
ECCCCCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHCHHHCCCCHHHHHCCCCEEE
ANLEDFQPDFSFQIPDEEALPIIFSLVQEEGLCLGGSTGINIAGAIRMARELGPGHTIVT
ECHHHCCCCCEEECCCCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHCCCCCEEEE
ILADYGTRYQSKLFNPAFLREKKLPVPAWMEGRSEIPVPFEQVAAS
EEEHHCCHHHHHCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA