Click here to switch to the map view.

The map label for this gene is frr

Identifier: 110633737

GI number: 110633737

Start: 1477120

End: 1477680

Strand: Direct

Name: frr

Synonym: Meso_1384

Alternate gene names: 110633737

Gene position: 1477120-1477680 (Clockwise)

Preceding gene: 110633736

Following gene: 110633738

Centisome position: 33.48

GC content: 59.36

Gene sequence:

>561_bases
ATGCCGGATGGTATTGATTTCAAGGATCTGCACCGGCGCTTCGACGGAGCCATTGCCGCGTTCAAGCACGATATCGCATC
GCTCAGGACGGGCCGGGCTTCGGCCAACCTGCTCGATCCAATTCATGTGGACGCGTATGGCGCCTCGATGCCGGTCAATC
AGGTTGCCACCGTCTCCGTTCCGGAACCTCGGATGATCTCCGTCTCCGTATGGGACCAGAGCCTGGTGGGCGCGGTGGAC
CGGGCAATTCGCGAAGCCAATCTGGGCTTCAATCCGATCGTGGAAGGATCGACGCTTCGCATCCCGCTTCCCGAACTTAA
TGAGGAGCGGCGAAAGGAACTGGTGAAAATCGCTCACCAATATGCCGAGCACGCCCGTGTTGCCGCGCGTCATGTGCGCC
GCGACGGCATGGAGCATCTCAAAAAGGCCGAAAAGGATGGCGAGATCAGCCAGGACGAGGCGCGCGTTCAGTCCGATCGC
GTGCAAAAGATGACCGACGAGACCATCGCCGCGATCGACAAGCTCCTTGCTGAAAAGGAAGTGGAGATCTTGCAGGTCTG
A

Upstream 100 bases:

>100_bases
GGGCGGGTTTGGAGCTATTCTGCGGGGCGGAGGTCACTGCACCATCGTCGACGATGACCCGGCTGCCCAACAACAGGCAA
GTGCGTAAGGAGGCTCAAAA

Downstream 100 bases:

>100_bases
TGGCCGCATAGAGCGGGCATCATCACCACAAAAGGGGATTCGAGCGGTGAAACCCGCGCATATCGCGATCATCATGGATG
GAAACGGCCGCTGGGCGCGC

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MPDGIDFKDLHRRFDGAIAAFKHDIASLRTGRASANLLDPIHVDAYGASMPVNQVATVSVPEPRMISVSVWDQSLVGAVD
RAIREANLGFNPIVEGSTLRIPLPELNEERRKELVKIAHQYAEHARVAARHVRRDGMEHLKKAEKDGEISQDEARVQSDR
VQKMTDETIAAIDKLLAEKEVEILQV

Sequences:

>Translated_186_residues
MPDGIDFKDLHRRFDGAIAAFKHDIASLRTGRASANLLDPIHVDAYGASMPVNQVATVSVPEPRMISVSVWDQSLVGAVD
RAIREANLGFNPIVEGSTLRIPLPELNEERRKELVKIAHQYAEHARVAARHVRRDGMEHLKKAEKDGEISQDEARVQSDR
VQKMTDETIAAIDKLLAEKEVEILQV
>Mature_185_residues
PDGIDFKDLHRRFDGAIAAFKHDIASLRTGRASANLLDPIHVDAYGASMPVNQVATVSVPEPRMISVSVWDQSLVGAVDR
AIREANLGFNPIVEGSTLRIPLPELNEERRKELVKIAHQYAEHARVAARHVRRDGMEHLKKAEKDGEISQDEARVQSDRV
QKMTDETIAAIDKLLAEKEVEILQV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=183, Percent_Identity=32.7868852459016, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI291042689, Length=184, Percent_Identity=32.6086956521739, Blast_Score=94, Evalue=8e-20,
Organism=Escherichia coli, GI1786368, Length=178, Percent_Identity=48.314606741573, Blast_Score=167, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24661488, Length=182, Percent_Identity=28.021978021978, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_MESSB (Q11IJ5)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673945.1
- ProteinModelPortal:   Q11IJ5
- SMR:   Q11IJ5
- STRING:   Q11IJ5
- GeneID:   4181231
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1384
- NMPDR:   fig|266779.1.peg.2208
- eggNOG:   COG0233
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- PhylomeDB:   Q11IJ5
- ProtClustDB:   PRK00083
- BioCyc:   MSP266779:MESO_1384-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20747; Mature: 20616

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGIDFKDLHRRFDGAIAAFKHDIASLRTGRASANLLDPIHVDAYGASMPVNQVATVSV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCEEEEEC
PEPRMISVSVWDQSLVGAVDRAIREANLGFNPIVEGSTLRIPLPELNEERRKELVKIAHQ
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YAEHARVAARHVRRDGMEHLKKAEKDGEISQDEARVQSDRVQKMTDETIAAIDKLLAEKE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEILQV
HHHHCC
>Mature Secondary Structure 
PDGIDFKDLHRRFDGAIAAFKHDIASLRTGRASANLLDPIHVDAYGASMPVNQVATVSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCEEEEEC
PEPRMISVSVWDQSLVGAVDRAIREANLGFNPIVEGSTLRIPLPELNEERRKELVKIAHQ
CCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
YAEHARVAARHVRRDGMEHLKKAEKDGEISQDEARVQSDRVQKMTDETIAAIDKLLAEKE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEILQV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA