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The map label for this gene is pyrH

Identifier: 110633736

GI number: 110633736

Start: 1476364

End: 1477107

Strand: Direct

Name: pyrH

Synonym: Meso_1383

Alternate gene names: 110633736

Gene position: 1476364-1477107 (Clockwise)

Preceding gene: 110633735

Following gene: 110633737

Centisome position: 33.46

GC content: 61.29

Gene sequence:

>744_bases
TTGACCCCACGATATCGCCGCGTCGTGTTGAAGGCCTCCGGCGAGGCCCTGATGGGTAAGCAGGGTTTCGGCATCGATGT
TTCGGTCGTCGATCAGATTGCAGCCGATATTGCGGACGCCCTTTCGCTCGGTGTCGAGGTGGGTGTGGTCATCGGCGGCG
GCAACATATTCCGCGGCGTGGCCGTCGCCTCCAAGGGCGGCGACCGGGTAACCGGCGACCACATGGGAATGCTGGCAACT
GTCATCAACTCGCTGGCGCTGCGCACCTCTCTGGCTAAAATCGGCGTCGAGGCCGTGGTGCTCTCGGCGATAGCCATGCC
GGAACTTTGCGAAAGTTTCTCCCAGCGCCAGGCCCTGGCCTATATGGATGCGGGCAAGGTTGTGATCTTCGCAGGCGGTA
CGGGCAACCCGTTTTTCACCACCGATTCCGCTGCGGCGCTGCGGGCCGCCGAAATAGGAGCCGATGCGCTCTTCAAGGGC
ACGCAGGTTGACGGTGTCTATTCGGCCGATCCGCGCAAGGATGCGAACGCGGTGCGTTACGATCACATCACGCACGATCA
GGTGATCCGCGATGGGCTTGCCATCATGGACACCGCGGCGATTGCGCTTGCGCGTGAGAACAACATTCCGATAATCGTTT
TTTCGATTCACGAAGCGGGCGGGTTTGGAGCTATTCTGCGGGGCGGAGGTCACTGCACCATCGTCGACGATGACCCGGCT
GCCCAACAACAGGCAAGTGCGTAA

Upstream 100 bases:

>100_bases
GCGTGACAACGCGGTGCCCTTCGTGTAGGGCCACTTGTCTGAAGCATCGAAACGGCTCTAATCGTCTAAGAGAAGCCTGC
CGATAAGAGGAGACGATCGC

Downstream 100 bases:

>100_bases
GGAGGCTCAAAAATGCCGGATGGTATTGATTTCAAGGATCTGCACCGGCGCTTCGACGGAGCCATTGCCGCGTTCAAGCA
CGATATCGCATCGCTCAGGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTPRYRRVVLKASGEALMGKQGFGIDVSVVDQIAADIADALSLGVEVGVVIGGGNIFRGVAVASKGGDRVTGDHMGMLAT
VINSLALRTSLAKIGVEAVVLSAIAMPELCESFSQRQALAYMDAGKVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKG
TQVDGVYSADPRKDANAVRYDHITHDQVIRDGLAIMDTAAIALARENNIPIIVFSIHEAGGFGAILRGGGHCTIVDDDPA
AQQQASA

Sequences:

>Translated_247_residues
MTPRYRRVVLKASGEALMGKQGFGIDVSVVDQIAADIADALSLGVEVGVVIGGGNIFRGVAVASKGGDRVTGDHMGMLAT
VINSLALRTSLAKIGVEAVVLSAIAMPELCESFSQRQALAYMDAGKVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKG
TQVDGVYSADPRKDANAVRYDHITHDQVIRDGLAIMDTAAIALARENNIPIIVFSIHEAGGFGAILRGGGHCTIVDDDPA
AQQQASA
>Mature_246_residues
TPRYRRVVLKASGEALMGKQGFGIDVSVVDQIAADIADALSLGVEVGVVIGGGNIFRGVAVASKGGDRVTGDHMGMLATV
INSLALRTSLAKIGVEAVVLSAIAMPELCESFSQRQALAYMDAGKVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKGT
QVDGVYSADPRKDANAVRYDHITHDQVIRDGLAIMDTAAIALARENNIPIIVFSIHEAGGFGAILRGGGHCTIVDDDPAA
QQQASA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=48.5106382978723, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_MESSB (Q11IJ6)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673944.1
- ProteinModelPortal:   Q11IJ6
- SMR:   Q11IJ6
- STRING:   Q11IJ6
- GeneID:   4181230
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1383
- NMPDR:   fig|266779.1.peg.2209
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q11IJ6
- ProtClustDB:   PRK00358
- BioCyc:   MSP266779:MESO_1383-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25497; Mature: 25366

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: BINDING 53-53 BINDING 54-54 BINDING 58-58 BINDING 73-73 BINDING 161-161 BINDING 162-162 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRYRRVVLKASGEALMGKQGFGIDVSVVDQIAADIADALSLGVEVGVVIGGGNIFRGV
CCCCCEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEE
AVASKGGDRVTGDHMGMLATVINSLALRTSLAKIGVEAVVLSAIAMPELCESFSQRQALA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
YMDAGKVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKGTQVDGVYSADPRKDANAVRY
EECCCCEEEEECCCCCCCEECCCHHHHHHHHCCHHHHCCCCCCCCEECCCCCCCCCCEEE
DHITHDQVIRDGLAIMDTAAIALARENNIPIIVFSIHEAGGFGAILRGGGHCTIVDDDPA
CCCCHHHHHHCCHHHHHHHHHEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEECCCCC
AQQQASA
CHHHCCC
>Mature Secondary Structure 
TPRYRRVVLKASGEALMGKQGFGIDVSVVDQIAADIADALSLGVEVGVVIGGGNIFRGV
CCCCEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEE
AVASKGGDRVTGDHMGMLATVINSLALRTSLAKIGVEAVVLSAIAMPELCESFSQRQALA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
YMDAGKVVIFAGGTGNPFFTTDSAAALRAAEIGADALFKGTQVDGVYSADPRKDANAVRY
EECCCCEEEEECCCCCCCEECCCHHHHHHHHCCHHHHCCCCCCCCEECCCCCCCCCCEEE
DHITHDQVIRDGLAIMDTAAIALARENNIPIIVFSIHEAGGFGAILRGGGHCTIVDDDPA
CCCCHHHHHHCCHHHHHHHHHEEEECCCCCEEEEEEECCCCCEEEEECCCEEEEECCCCC
AQQQASA
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA