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The map label for this gene is mmsB [H]

Identifier: 110633661

GI number: 110633661

Start: 1399035

End: 1399919

Strand: Reverse

Name: mmsB [H]

Synonym: Meso_1308

Alternate gene names: 110633661

Gene position: 1399919-1399035 (Counterclockwise)

Preceding gene: 110633662

Following gene: 110633655

Centisome position: 31.73

GC content: 63.28

Gene sequence:

>885_bases
ATGACCAAAATCGCCTTTATCGGCCTCGGAAACATGGGAAACCCGATGGCCGCCAACCTGGTCAAAGCCGGGCATGAGGT
GAATGGCTTCGATCTCTTGCCCGAGAATCTTGCAAAAGCGGAAAAGAGCGGCGTTTTCCGGGCGGAGAACGCGCAGAAGG
CAATCGAAGGTGCTGATGCGATCATCACCATGCTGCCGGCGGGCAAGCATGTGCTCACGGTCTATGAGGACATCCTGGCC
AAGGCGGCGGCGGGCACGCTCTTCATCGATTCATCGACCATCGACGTCGCCTCGGCGCGAGTGGCCCACTTGATGGCCCG
CAAGCACGGTCATCTGTCTGTCGATGCACCCGTTTCCGGCGGGGTGGTCGGAGCGGAAGCGGGCAGCCTGACCTTCATGG
CCGGAGGCTCCGCTGAGGCCTTCGCCAAGGCCGAGCCCATCTTGAAGCCGATGGCCGGCCGCATCGTTCATTGCGGCGAT
GGGGGTGCCGGCCAGGCCGCGAAGATCTGCAACAATATGATCCTGGGCATCTCGATGATCGGCGTCGCGGAAGCCTTCGT
GCTGGCGGAAAAGCTCGGACTTTCGCACCAGGCCCTCTTTGAGGTGGCGTCGGCTTCATCGGGCCAGTGCTGGTCGCTGA
CAACCTATTGCCCGGTGCCGGGGCCGGTGCCGACCTCCCCCGCCAACCGGGACTACCAGCCAGGCTTTGCCACAAGCCTG
ATGCTCAAGGACCTGCGCCTTGCCCAGGAGGCCGCGCAGACGGCCGGCGCCGTAACCCCGCTCGGAGCCGAAGCGGCGCA
GATCTATGCGCTCTTCGATGCGATGGGCCAAGGCGGACGGGACTTTTCAGGCATCATAAGCTTGCTGCGCGGCACTACCA
AATGA

Upstream 100 bases:

>100_bases
GGGCAATGTCTGGTCGGTCGGGACCTACTGGCCGAAGGCGCATGAAGAGGCCTGAAATTTCCTATTCGACAGTGGCCGGT
GCCCATTATTCGGAGGTTAT

Downstream 100 bases:

>100_bases
TCCATCGGCGAAAGCTTTCACCGGCGAGGAAAAAATCCCGAATTAAGGAATAAGCAAGCACTCGCTAACCTCCCGGTAAC
GATGTCCAGCTAAAACAAAA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTKIAFIGLGNMGNPMAANLVKAGHEVNGFDLLPENLAKAEKSGVFRAENAQKAIEGADAIITMLPAGKHVLTVYEDILA
KAAAGTLFIDSSTIDVASARVAHLMARKHGHLSVDAPVSGGVVGAEAGSLTFMAGGSAEAFAKAEPILKPMAGRIVHCGD
GGAGQAAKICNNMILGISMIGVAEAFVLAEKLGLSHQALFEVASASSGQCWSLTTYCPVPGPVPTSPANRDYQPGFATSL
MLKDLRLAQEAAQTAGAVTPLGAEAAQIYALFDAMGQGGRDFSGIISLLRGTTK

Sequences:

>Translated_294_residues
MTKIAFIGLGNMGNPMAANLVKAGHEVNGFDLLPENLAKAEKSGVFRAENAQKAIEGADAIITMLPAGKHVLTVYEDILA
KAAAGTLFIDSSTIDVASARVAHLMARKHGHLSVDAPVSGGVVGAEAGSLTFMAGGSAEAFAKAEPILKPMAGRIVHCGD
GGAGQAAKICNNMILGISMIGVAEAFVLAEKLGLSHQALFEVASASSGQCWSLTTYCPVPGPVPTSPANRDYQPGFATSL
MLKDLRLAQEAAQTAGAVTPLGAEAAQIYALFDAMGQGGRDFSGIISLLRGTTK
>Mature_293_residues
TKIAFIGLGNMGNPMAANLVKAGHEVNGFDLLPENLAKAEKSGVFRAENAQKAIEGADAIITMLPAGKHVLTVYEDILAK
AAAGTLFIDSSTIDVASARVAHLMARKHGHLSVDAPVSGGVVGAEAGSLTFMAGGSAEAFAKAEPILKPMAGRIVHCGDG
GAGQAAKICNNMILGISMIGVAEAFVLAEKLGLSHQALFEVASASSGQCWSLTTYCPVPGPVPTSPANRDYQPGFATSLM
LKDLRLAQEAAQTAGAVTPLGAEAAQIYALFDAMGQGGRDFSGIISLLRGTTK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=45.8904109589041, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI40556376, Length=293, Percent_Identity=25.5972696245734, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI145693186, Length=286, Percent_Identity=34.2657342657343, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=33.7837837837838, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=31.740614334471, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789092, Length=296, Percent_Identity=29.3918918918919, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=297, Percent_Identity=42.4242424242424, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=42.7586206896552, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=42.7586206896552, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI28574115, Length=295, Percent_Identity=23.0508474576271, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30092; Mature: 29961

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIAFIGLGNMGNPMAANLVKAGHEVNGFDLLPENLAKAEKSGVFRAENAQKAIEGADA
CCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEECCCHHHHHHCCCE
IITMLPAGKHVLTVYEDILAKAAAGTLFIDSSTIDVASARVAHLMARKHGHLSVDAPVSG
EEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCCC
GVVGAEAGSLTFMAGGSAEAFAKAEPILKPMAGRIVHCGDGGAGQAAKICNNMILGISMI
CEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
GVAEAFVLAEKLGLSHQALFEVASASSGQCWSLTTYCPVPGPVPTSPANRDYQPGFATSL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
MLKDLRLAQEAAQTAGAVTPLGAEAAQIYALFDAMGQGGRDFSGIISLLRGTTK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TKIAFIGLGNMGNPMAANLVKAGHEVNGFDLLPENLAKAEKSGVFRAENAQKAIEGADA
CEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEECCCHHHHHHCCCE
IITMLPAGKHVLTVYEDILAKAAAGTLFIDSSTIDVASARVAHLMARKHGHLSVDAPVSG
EEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCCC
GVVGAEAGSLTFMAGGSAEAFAKAEPILKPMAGRIVHCGDGGAGQAAKICNNMILGISMI
CEEECCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHH
GVAEAFVLAEKLGLSHQALFEVASASSGQCWSLTTYCPVPGPVPTSPANRDYQPGFATSL
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
MLKDLRLAQEAAQTAGAVTPLGAEAAQIYALFDAMGQGGRDFSGIISLLRGTTK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]