Click here to switch to the map view.

The map label for this gene is icd [H]

Identifier: 110633620

GI number: 110633620

Start: 1362499

End: 1363713

Strand: Reverse

Name: icd [H]

Synonym: Meso_1267

Alternate gene names: 110633620

Gene position: 1363713-1362499 (Counterclockwise)

Preceding gene: 110633625

Following gene: 110633616

Centisome position: 30.91

GC content: 60.33

Gene sequence:

>1215_bases
ATGGCGAAGATCAAGGTGGACAATCCTGTCGTCGAACTGGATGGCGACGAGATGACGCGCATCATCTGGCAGCTCATCAA
GGACAAGCTGATCCACCCTTATCTCGATATCGATCTCAAATATTACGACCTCGGCATCCAGAAGCGCGACGAAACCGACG
ATCAGATCACCATCGATGCGGCCAAAGCTATCAAGAAATACGGCGTCGGCGTGAAATGCGCCACCATCACACCGGACGAA
GCGCGGGTGGAGGAATTCAAGCTCAAGAAGATGTGGAAGTCGCCCAACGGCACGATCCGCAACATCCTGGGCGGCGTCAT
CTTCCGCGAGCCGATCATCTGCCGCAACGTGCCGCGCCTGGTGCCAGGCTGGACGAAGCCGATCGTGGTCGGCCGCCATG
CCTTTGGCGATCAGTACCGCGCGACGGATTTCAAGTTCCCCGGCAAGGGCAAGCTGTCCATCAAGTTTGTCGGCGAGGAC
GGAGAGGTAATCGAGCACGAGGTGTTTGACGCGCCGGGCTCGGGCGTGGCCATGGCCATGTACAATCTGGACGACTCGAT
CCGCGACTTTGCGCGCGCCTCCTTCAATTACGGCCTGCAGCGCGGGTTCCCGGTCTATCTTTCCACCAAGAACACGATCC
TCAAGGCCTATGACGGGCGCTTCAAGGACATCTTCCAGGAAATCTACGAGACGGAGTTCGAGGCCGCCTTCAAGGAAAGG
AAGCTCTGGTACGAGCACCGGCTGATCGACGACATGGTGGCGGCGAGCCTCAAATGGTCCGGCGGCTATGTCTGGGCGTG
CAAAAACTATGACGGCGACGTGCAGTCGGACATCGTGGCCCAGGGCTTCGGCTCCCTCGGCCTGATGACCTCCGTGCTCA
TGACGCCGGACGGCAAGACCGTGGAAGCCGAGGCCGCCCACGGCACGGTGACGCGTCACTACCGCCAGCACCAGAAGGGC
GAAGAGACCTCCACGAACTCCATCGCCTCCATCTTCGCCTGGACGCGCGGGCTTGCCCATCGCGCGAAGCTCGACGGCAA
TGCGGAACTCAAGAAGTTCGCCGAAACGCTGGAGCGTGTCTGCGTGGATACCGTGGAAGCAGGCCACATGACCAAGGACC
TCGCGCTCCTCATCGGGCCGGATCAGCCTTGGCTTTCTACGACTGGCTTCCTGGACAAGATCGACGAGAATTTGCAGAAG
GCCATGGCGGCCTGA

Upstream 100 bases:

>100_bases
GCATCCGCCGTCTTTGCCAAGCGGCGCAACGATGCTATAGGGGCGCCACCTTCAAGTATATCTGTTGGCGGCGCGGTCCG
CCTTTTCCGGAGAGAGGCTT

Downstream 100 bases:

>100_bases
CAAGCATGAAAAAGGGCGGCCCAGCCGCCCTTTTTATTTGATCTCGCTTTCCGCTTGGATCAGCCGGCGAGCGCCGCCCG
CACAGCCTCCACCGCGGCTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAKIKVDNPVVELDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLGIQKRDETDDQITIDAAKAIKKYGVGVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICRNVPRLVPGWTKPIVVGRHAFGDQYRATDFKFPGKGKLSIKFVGED
GEVIEHEVFDAPGSGVAMAMYNLDDSIRDFARASFNYGLQRGFPVYLSTKNTILKAYDGRFKDIFQEIYETEFEAAFKER
KLWYEHRLIDDMVAASLKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDGNAELKKFAETLERVCVDTVEAGHMTKDLALLIGPDQPWLSTTGFLDKIDENLQK
AMAA

Sequences:

>Translated_404_residues
MAKIKVDNPVVELDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLGIQKRDETDDQITIDAAKAIKKYGVGVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICRNVPRLVPGWTKPIVVGRHAFGDQYRATDFKFPGKGKLSIKFVGED
GEVIEHEVFDAPGSGVAMAMYNLDDSIRDFARASFNYGLQRGFPVYLSTKNTILKAYDGRFKDIFQEIYETEFEAAFKER
KLWYEHRLIDDMVAASLKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
EETSTNSIASIFAWTRGLAHRAKLDGNAELKKFAETLERVCVDTVEAGHMTKDLALLIGPDQPWLSTTGFLDKIDENLQK
AMAA
>Mature_403_residues
AKIKVDNPVVELDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLGIQKRDETDDQITIDAAKAIKKYGVGVKCATITPDEA
RVEEFKLKKMWKSPNGTIRNILGGVIFREPIICRNVPRLVPGWTKPIVVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDG
EVIEHEVFDAPGSGVAMAMYNLDDSIRDFARASFNYGLQRGFPVYLSTKNTILKAYDGRFKDIFQEIYETEFEAAFKERK
LWYEHRLIDDMVAASLKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGE
ETSTNSIASIFAWTRGLAHRAKLDGNAELKKFAETLERVCVDTVEAGHMTKDLALLIGPDQPWLSTTGFLDKIDENLQKA
MAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=68.6274509803922, Blast_Score=587, Evalue=1e-168,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=66.8292682926829, Blast_Score=570, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=70.1492537313433, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=67.3218673218673, Blast_Score=577, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6323203, Length=409, Percent_Identity=63.080684596577, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320137, Length=410, Percent_Identity=63.6585365853659, Blast_Score=538, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6324319, Length=409, Percent_Identity=62.3471882640587, Blast_Score=538, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330987, Length=407, Percent_Identity=65.3562653562654, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330985, Length=407, Percent_Identity=65.3562653562654, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574947, Length=407, Percent_Identity=65.3562653562654, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660849, Length=407, Percent_Identity=65.3562653562654, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI21356561, Length=407, Percent_Identity=65.3562653562654, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660856, Length=407, Percent_Identity=65.3562653562654, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330983, Length=407, Percent_Identity=65.3562653562654, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660868, Length=407, Percent_Identity=65.3562653562654, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24660860, Length=407, Percent_Identity=65.3562653562654, Blast_Score=560, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45475; Mature: 45344

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVDNPVVELDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLGIQKRDETDDQITIDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEHH
AKAIKKYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICRNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIVVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGEVIEHEVFDAPGSGVAMAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCCCEEEEE
YNLDDSIRDFARASFNYGLQRGFPVYLSTKNTILKAYDGRFKDIFQEIYETEFEAAFKER
ECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHH
KLWYEHRLIDDMVAASLKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELKKFAETLERV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVEAGHMTKDLALLIGPDQPWLSTTGFLDKIDENLQKAMAA
HHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVDNPVVELDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLGIQKRDETDDQITIDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCCCCEEEEHH
AKAIKKYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICRNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTKPIVVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGEVIEHEVFDAPGSGVAMAM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEHHHHHCCCCCCEEEEE
YNLDDSIRDFARASFNYGLQRGFPVYLSTKNTILKAYDGRFKDIFQEIYETEFEAAFKER
ECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHH
KLWYEHRLIDDMVAASLKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
HHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELKKFAETLERV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CVDTVEAGHMTKDLALLIGPDQPWLSTTGFLDKIDENLQKAMAA
HHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]