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The map label for this gene is bcr [H]

Identifier: 110633625

GI number: 110633625

Start: 1367373

End: 1368620

Strand: Reverse

Name: bcr [H]

Synonym: Meso_1272

Alternate gene names: 110633625

Gene position: 1368620-1367373 (Counterclockwise)

Preceding gene: 110633626

Following gene: 110633620

Centisome position: 31.02

GC content: 61.46

Gene sequence:

>1248_bases
ATGGACGATTCCCTCGCGCGAGAGGCGCCCGCCTCGGCTGCCTTGTCCATTGGGAAAACAGAATTCATCGCACTCATGGC
GGCCTTGATGGCGCTCAATGCGATGGCGATCGACATCATGCTGCCAGGCCTGCAGCAGATCGGGTCCGCACTCGGCGTGG
CCGACGAGAACAGCCGTCAGCTCATCATCAGCGCTTATGTGCTGGGGCTCGGCGGCGCCCAGCTTTTCTATGGGCCGATA
ACGGACCGCTTCGGACGCCGCACCCCTCTGCTCATCGGCCTTGTCATTTACGTCGCCACAGGATTTGCCTGCGCTTTTGC
GCCGAGCTTCGCAGCCATGCTGGTGCTCCGCCTCCTGCAGGGAATCGGGGCGGCCGCAACCAGGGTGGTCGCGATCTCGG
CTATCCGGGACGTTTATGGCGGCCGGCGCATGGCCGAAGTGATGTCGATGGTCATGATGGTTTTCATGATTATCCCAGTC
GTGGCGCCCAGCCTCGGCCAGGTGGCAATGCTGTTCGACGATTGGCCGAGCATTTTCCTGCTCATGGGCTTCATGTCCCT
CATCATCACGGTTTGGACGCTTTTGCGCCTACCCGAAACGCTGGCACCGGAAATGAAGCGCTCGCTCTCCCTCGGCTCGA
TCATGGAGGGTTTCCGCCTCGTCCTCACCAACCGGGTGGCGCTTTGCTACACACTGGCCAGCACGGCCATTTTCGGGGCT
CTGTTCGGCTTCATCAATTCCGCGCAGCAGATCTATGTGGAGATCTATGATATGGGAACGCTGTTCCCGCTCATGTTCGC
CATTGGCGCCGGGCTGATGGCGGTTTCCTCCTTTACAAGCGCCCGGCTCGTTGGCCGTTACGGGATGCGCCGCCTCTCCC
ACGCCGCGCTGCTGGGCTTCGTGGCTGTCTCCGGAATCTGGCTGATCATGGCCCTTTTCGACTATGAGCCCTTTTGGCTC
TTCTTTATCCTGTTCTCGCTGGCCATGTTCCAGTTCGGCTGGGTGGCCCCGAATTTCAATTCCATAGCCATGGAGCCGCT
GGGCCGCGTGGCAGGTACCGCGGCCGCGGTGCAGGGATTCATAACGACGCTTGGAGGCGGCGTGCTTGGCGCCCTCATCG
GCCTGTCTTTTGACGGTACGCTGGTGCCGCTGGCGGCTGGCTATTTCATCTCAGGAGGTGTCGGCCTGATCCTGGTTCTG
ATCGGCGAACGCGGACAGCTGTTCCGCCAGGTAAGCGCGCCGGTTTAG

Upstream 100 bases:

>100_bases
CATTTTTTCCGGCCCCTTCAGGCGCTCCTGCCTGGGGGTCGCTATTTCTTTACGACAGCGCGCCCTTGTCCTGCAGGCGC
GCCTTTGCCGGAGCAAGAAC

Downstream 100 bases:

>100_bases
AGAATTCCGAGACCGGCAAAGTCGAAGAGTTGCCGGTCCAGCAGATGCGACGGCCGCACATTGGCGAGCGCGCGGATCAT
TGTATCCTTGCGGCCGGGCA

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDDSLAREAPASAALSIGKTEFIALMAALMALNAMAIDIMLPGLQQIGSALGVADENSRQLIISAYVLGLGGAQLFYGPI
TDRFGRRTPLLIGLVIYVATGFACAFAPSFAAMLVLRLLQGIGAAATRVVAISAIRDVYGGRRMAEVMSMVMMVFMIIPV
VAPSLGQVAMLFDDWPSIFLLMGFMSLIITVWTLLRLPETLAPEMKRSLSLGSIMEGFRLVLTNRVALCYTLASTAIFGA
LFGFINSAQQIYVEIYDMGTLFPLMFAIGAGLMAVSSFTSARLVGRYGMRRLSHAALLGFVAVSGIWLIMALFDYEPFWL
FFILFSLAMFQFGWVAPNFNSIAMEPLGRVAGTAAAVQGFITTLGGGVLGALIGLSFDGTLVPLAAGYFISGGVGLILVL
IGERGQLFRQVSAPV

Sequences:

>Translated_415_residues
MDDSLAREAPASAALSIGKTEFIALMAALMALNAMAIDIMLPGLQQIGSALGVADENSRQLIISAYVLGLGGAQLFYGPI
TDRFGRRTPLLIGLVIYVATGFACAFAPSFAAMLVLRLLQGIGAAATRVVAISAIRDVYGGRRMAEVMSMVMMVFMIIPV
VAPSLGQVAMLFDDWPSIFLLMGFMSLIITVWTLLRLPETLAPEMKRSLSLGSIMEGFRLVLTNRVALCYTLASTAIFGA
LFGFINSAQQIYVEIYDMGTLFPLMFAIGAGLMAVSSFTSARLVGRYGMRRLSHAALLGFVAVSGIWLIMALFDYEPFWL
FFILFSLAMFQFGWVAPNFNSIAMEPLGRVAGTAAAVQGFITTLGGGVLGALIGLSFDGTLVPLAAGYFISGGVGLILVL
IGERGQLFRQVSAPV
>Mature_415_residues
MDDSLAREAPASAALSIGKTEFIALMAALMALNAMAIDIMLPGLQQIGSALGVADENSRQLIISAYVLGLGGAQLFYGPI
TDRFGRRTPLLIGLVIYVATGFACAFAPSFAAMLVLRLLQGIGAAATRVVAISAIRDVYGGRRMAEVMSMVMMVFMIIPV
VAPSLGQVAMLFDDWPSIFLLMGFMSLIITVWTLLRLPETLAPEMKRSLSLGSIMEGFRLVLTNRVALCYTLASTAIFGA
LFGFINSAQQIYVEIYDMGTLFPLMFAIGAGLMAVSSFTSARLVGRYGMRRLSHAALLGFVAVSGIWLIMALFDYEPFWL
FFILFSLAMFQFGWVAPNFNSIAMEPLGRVAGTAAAVQGFITTLGGGVLGALIGLSFDGTLVPLAAGYFISGGVGLILVL
IGERGQLFRQVSAPV

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=364, Percent_Identity=28.021978021978, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790146, Length=362, Percent_Identity=30.1104972375691, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082312, Length=351, Percent_Identity=26.4957264957265, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI48994889, Length=162, Percent_Identity=30.2469135802469, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790794, Length=197, Percent_Identity=27.9187817258883, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787065, Length=229, Percent_Identity=27.9475982532751, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44277; Mature: 44277

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDSLAREAPASAALSIGKTEFIALMAALMALNAMAIDIMLPGLQQIGSALGVADENSRQ
CCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCE
LIISAYVLGLGGAQLFYGPITDRFGRRTPLLIGLVIYVATGFACAFAPSFAAMLVLRLLQ
EEHHHHHHHCCCHHHEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGAAATRVVAISAIRDVYGGRRMAEVMSMVMMVFMIIPVVAPSLGQVAMLFDDWPSIFL
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHH
LMGFMSLIITVWTLLRLPETLAPEMKRSLSLGSIMEGFRLVLTNRVALCYTLASTAIFGA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGFINSAQQIYVEIYDMGTLFPLMFAIGAGLMAVSSFTSARLVGRYGMRRLSHAALLGF
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVSGIWLIMALFDYEPFWLFFILFSLAMFQFGWVAPNFNSIAMEPLGRVAGTAAAVQGF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ITTLGGGVLGALIGLSFDGTLVPLAAGYFISGGVGLILVLIGERGQLFRQVSAPV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHEEEEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MDDSLAREAPASAALSIGKTEFIALMAALMALNAMAIDIMLPGLQQIGSALGVADENSRQ
CCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCE
LIISAYVLGLGGAQLFYGPITDRFGRRTPLLIGLVIYVATGFACAFAPSFAAMLVLRLLQ
EEHHHHHHHCCCHHHEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGAAATRVVAISAIRDVYGGRRMAEVMSMVMMVFMIIPVVAPSLGQVAMLFDDWPSIFL
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHH
LMGFMSLIITVWTLLRLPETLAPEMKRSLSLGSIMEGFRLVLTNRVALCYTLASTAIFGA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFGFINSAQQIYVEIYDMGTLFPLMFAIGAGLMAVSSFTSARLVGRYGMRRLSHAALLGF
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVSGIWLIMALFDYEPFWLFFILFSLAMFQFGWVAPNFNSIAMEPLGRVAGTAAAVQGF
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ITTLGGGVLGALIGLSFDGTLVPLAAGYFISGGVGLILVLIGERGQLFRQVSAPV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHEEEEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]