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The map label for this gene is clpP

Identifier: 110633522

GI number: 110633522

Start: 1277760

End: 1278392

Strand: Direct

Name: clpP

Synonym: Meso_1169

Alternate gene names: 110633522

Gene position: 1277760-1278392 (Clockwise)

Preceding gene: 110633520

Following gene: 110633523

Centisome position: 28.96

GC content: 59.08

Gene sequence:

>633_bases
ATGAAGAATCCCGTCGAGACCGCGATGAATCTGGTGCCCATGGTCGTCGAGCAGACGAACCGCGGCGAACGGGCTTATGA
TATCTTTTCGCGCCTTTTGAAGGAGCGAATCATCTTCATAACCGGGCCGGTCGAAGATGGCATGGCCACTCTCGTATGCG
CACAGCTTCTGTTCCTGGAGGCGGAAAACCCGAAAAAGGAGATCGCGCTTTACATCAATTCGCCGGGTGGCGTCGTGACC
AGCGGGATGGCGATCTACGATACGATGCAGTTCATTCAGCCGCCGGTCTCGACGCTTTGCATCGGACAGGCAGCCTCCAT
GGGCTCGCTCCTGCTCTGCGCCGGGCACAAGGACATGCGCTTCGCTACGCCGAACGCCCGCGTCATGGTGCACCAGCCCT
CCGGCGGCTTCCAGGGCCAGGCCTCCGATATCGAGCGCCATGCCCAGGACATCATCAAGCTGAAAAGACGCTTGAACGAG
ATCTATGTTAAGCACACGGGACAGGACTACGACACGATCGAGCGGACGCTCGACCGTGATCATTTCATGACCGCTGACGA
AGCACAGGCCTTTGGCTTGGTGGACAGGGTGATAAGCGAGCGCGAGGCGATCGAGGCTCCACGAACCTCGTGA

Upstream 100 bases:

>100_bases
GCGTTGCTGCCGGTCTTGCGCAATAGCAAGTTGCCATCCTATCTAGGGGCATCAAGACTCCATCACTGGAGTGATGGATA
CCAGCTTCGAAGGAACCCCC

Downstream 100 bases:

>100_bases
TCGCCCGCAAACGTGACGCAGCGTAGGGCGGAGGCTGTCCAGCCCCTCCTGGAATCGCAAGACCCCATTTATCAAAATCG
GTGGCTTTGCGTCATTTCTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKNPVETAMNLVPMVVEQTNRGERAYDIFSRLLKERIIFITGPVEDGMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
SGMAIYDTMQFIQPPVSTLCIGQAASMGSLLLCAGHKDMRFATPNARVMVHQPSGGFQGQASDIERHAQDIIKLKRRLNE
IYVKHTGQDYDTIERTLDRDHFMTADEAQAFGLVDRVISEREAIEAPRTS

Sequences:

>Translated_210_residues
MKNPVETAMNLVPMVVEQTNRGERAYDIFSRLLKERIIFITGPVEDGMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
SGMAIYDTMQFIQPPVSTLCIGQAASMGSLLLCAGHKDMRFATPNARVMVHQPSGGFQGQASDIERHAQDIIKLKRRLNE
IYVKHTGQDYDTIERTLDRDHFMTADEAQAFGLVDRVISEREAIEAPRTS
>Mature_210_residues
MKNPVETAMNLVPMVVEQTNRGERAYDIFSRLLKERIIFITGPVEDGMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
SGMAIYDTMQFIQPPVSTLCIGQAASMGSLLLCAGHKDMRFATPNARVMVHQPSGGFQGQASDIERHAQDIIKLKRRLNE
IYVKHTGQDYDTIERTLDRDHFMTADEAQAFGLVDRVISEREAIEAPRTS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=60.2094240837696, Blast_Score=253, Evalue=8e-68,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=65.2849740932643, Blast_Score=277, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=62.9032258064516, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=62.6315789473684, Blast_Score=265, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_MESSB (Q11J60)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673730.1
- ProteinModelPortal:   Q11J60
- SMR:   Q11J60
- STRING:   Q11J60
- MEROPS:   S14.001
- GeneID:   4179628
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1169
- NMPDR:   fig|266779.1.peg.2417
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   DTFLEAE
- PhylomeDB:   Q11J60
- ProtClustDB:   PRK00277
- BioCyc:   MSP266779:MESO_1169-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23371; Mature: 23371

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 106-106 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPVETAMNLVPMVVEQTNRGERAYDIFSRLLKERIIFITGPVEDGMATLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTSGMAIYDTMQFIQPPVSTLCIGQAASMGSLLLCAGHKDMR
CCCCCEEEEEEECCCCCCHHCCHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEECCCCCE
FATPNARVMVHQPSGGFQGQASDIERHAQDIIKLKRRLNEIYVKHTGQDYDTIERTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HFMTADEAQAFGLVDRVISEREAIEAPRTS
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNPVETAMNLVPMVVEQTNRGERAYDIFSRLLKERIIFITGPVEDGMATLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTSGMAIYDTMQFIQPPVSTLCIGQAASMGSLLLCAGHKDMR
CCCCCEEEEEEECCCCCCHHCCHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEECCCCCE
FATPNARVMVHQPSGGFQGQASDIERHAQDIIKLKRRLNEIYVKHTGQDYDTIERTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HFMTADEAQAFGLVDRVISEREAIEAPRTS
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA