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The map label for this gene is clpX

Identifier: 110633523

GI number: 110633523

Start: 1278724

End: 1279998

Strand: Direct

Name: clpX

Synonym: Meso_1170

Alternate gene names: 110633523

Gene position: 1278724-1279998 (Clockwise)

Preceding gene: 110633522

Following gene: 110633524

Centisome position: 28.98

GC content: 60.71

Gene sequence:

>1275_bases
ATGAGCAAGATCAGCAACAGCGGCGGTGATTCCAAGAACACGCTGTACTGCTCGTTCTGCGGCAAGAGCCAGCATGAGGT
CCGTAAGCTGATCGCCGGCCCGACCGTCTTCATCTGCGATGAATGCGTCGAGCTGTGCATGGACATCATCCGCGAGGAGA
ACAAGTCCTCGATGGTGAAGTCGCGCGAGGGTGTTCCCACCCCGCAGGAGATCATGGAGGTTCTGGACGATTACGTGATC
GGCCAGACCTACGCCAAGCGCGTGCTCTCGGTAGCCGTTCACAACCACTACAAGCGGCTTGCCCACGCGGGCAAGAACGC
GGATGTGGAGCTGTCGAAGTCCAACATCCTGCTGATCGGCCCGACGGGGTGCGGAAAGACGCTGCTCGCCCAGACGCTGG
CCCGCATTATCGACGTTCCCTTCACGATGGCCGACGCCACTACGTTGACCGAGGCAGGCTATGTCGGCGAGGATGTCGAG
AACATCATCCTGAAGCTGTTGCAGTCGGCGGATTATAATGTCGAGCGCGCGCAGCGCGGCATCGTCTATATCGACGAGAT
CGACAAAATATCCCGCAAGTCGGACAACCCCTCGATCACCCGCGACGTGTCGGGCGAGGGGGTGCAGCAGGCGCTCCTGA
AGATCATGGAAGGGACGGTTGCCTCCGTGCCTCCCCAGGGCGGTCGCAAGCATCCGCAGCAGGAATTCCTCCAGGTGGAT
ACCTCGTCGATCCTGTTCATCTGCGGCGGCGCCTTTGCAGGGCTGGAGAAGATCATTTCCGATCGCGGCAAGAAAACCTC
CATCGGCTTCGGCGCAAGCGTATCCTCTCCGGAGGACCGCCGCGCGGGCGAGCTCCTGCGCCAGGTGGAGCCGGAAGACC
TGTTGAAGTTCGGTCTGATCCCTGAATTTGTCGGGCGCCTGCCCATCCTTGCGACATTGGAGGATCTGGACGAGGAAGCG
CTCGTGCAGATCCTCACCGAGCCCAAGAACGCGCTGGTGAAACAGTATCAGCGCCTGTTCGAGATGGAGAATGTGGAACT
TACCTTCCATGAAAACGCGCTGCGGGCGATTGCCCGCAAGGCGATCGAGCGCAAGACGGGCGCTCGGGGCCTGCGTTCGA
TCATGGAGGCGATCCTGCTCGACACCATGTTCGAGCTACCGGCGCTGGAAGGCGTTCAGGAGGTTGTTATCTCCGAAGAT
GTGGTCGCCGGCAGTGCCAGGCCCCTCTACATCTACGCCGAACGCGAAAAGGAAAAGGGTAGCGTCAGCGCGTGA

Upstream 100 bases:

>100_bases
GGATGGGAGGGATGACGGAGCGACCTTGCGGTCTGCCGTCGCCTGCTCCCCCCGGTGTCACCGAGGGTGGATGCCGGCAG
TACTGAAAGGAAAGTGAAGC

Downstream 100 bases:

>100_bases
TCGAGAATGGCCCACTCATTCGGAAAAGAGCGGCGGCGGCGGCCGCCGTGTTCTCCCTTCCGTTGGGCCTCATCCGCTCC
GTACCGGGGTTGATATTGAC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSKISNSGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVKSREGVPTPQEIMEVLDDYVI
GQTYAKRVLSVAVHNHYKRLAHAGKNADVELSKSNILLIGPTGCGKTLLAQTLARIIDVPFTMADATTLTEAGYVGEDVE
NIILKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVD
TSSILFICGGAFAGLEKIISDRGKKTSIGFGASVSSPEDRRAGELLRQVEPEDLLKFGLIPEFVGRLPILATLEDLDEEA
LVQILTEPKNALVKQYQRLFEMENVELTFHENALRAIARKAIERKTGARGLRSIMEAILLDTMFELPALEGVQEVVISED
VVAGSARPLYIYAEREKEKGSVSA

Sequences:

>Translated_424_residues
MSKISNSGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVKSREGVPTPQEIMEVLDDYVI
GQTYAKRVLSVAVHNHYKRLAHAGKNADVELSKSNILLIGPTGCGKTLLAQTLARIIDVPFTMADATTLTEAGYVGEDVE
NIILKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVD
TSSILFICGGAFAGLEKIISDRGKKTSIGFGASVSSPEDRRAGELLRQVEPEDLLKFGLIPEFVGRLPILATLEDLDEEA
LVQILTEPKNALVKQYQRLFEMENVELTFHENALRAIARKAIERKTGARGLRSIMEAILLDTMFELPALEGVQEVVISED
VVAGSARPLYIYAEREKEKGSVSA
>Mature_423_residues
SKISNSGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVKSREGVPTPQEIMEVLDDYVIG
QTYAKRVLSVAVHNHYKRLAHAGKNADVELSKSNILLIGPTGCGKTLLAQTLARIIDVPFTMADATTLTEAGYVGEDVEN
IILKLLQSADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDT
SSILFICGGAFAGLEKIISDRGKKTSIGFGASVSSPEDRRAGELLRQVEPEDLLKFGLIPEFVGRLPILATLEDLDEEAL
VQILTEPKNALVKQYQRLFEMENVELTFHENALRAIARKAIERKTGARGLRSIMEAILLDTMFELPALEGVQEVVISEDV
VAGSARPLYIYAEREKEKGSVSA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=330, Percent_Identity=54.5454545454545, Blast_Score=333, Evalue=1e-91,
Organism=Escherichia coli, GI1786642, Length=414, Percent_Identity=72.2222222222222, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=43.2692307692308, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=313, Percent_Identity=47.6038338658147, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71982905, Length=313, Percent_Identity=47.6038338658147, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71988663, Length=392, Percent_Identity=39.030612244898, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71988660, Length=258, Percent_Identity=39.922480620155, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319704, Length=433, Percent_Identity=38.568129330254, Blast_Score=263, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24648291, Length=336, Percent_Identity=49.1071428571429, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI24648289, Length=336, Percent_Identity=49.1071428571429, Blast_Score=317, Evalue=8e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_MESSB (Q11J59)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673731.1
- ProteinModelPortal:   Q11J59
- STRING:   Q11J59
- GeneID:   4179629
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1170
- NMPDR:   fig|266779.1.peg.2416
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q11J59
- ProtClustDB:   PRK05342
- BioCyc:   MSP266779:MESO_1170-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46585; Mature: 46454

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKISNSGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVK
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
SREGVPTPQEIMEVLDDYVIGQTYAKRVLSVAVHNHYKRLAHAGKNADVELSKSNILLIG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEE
PTGCGKTLLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQSADYNVERAQRG
CCCCCHHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCC
IVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVD
CEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHC
TSSILFICGGAFAGLEKIISDRGKKTSIGFGASVSSPEDRRAGELLRQVEPEDLLKFGLI
CCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCC
PEFVGRLPILATLEDLDEEALVQILTEPKNALVKQYQRLFEMENVELTFHENALRAIARK
HHHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
AIERKTGARGLRSIMEAILLDTMFELPALEGVQEVVISEDVVAGSARPLYIYAEREKEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
SVSA
CCCC
>Mature Secondary Structure 
SKISNSGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSMVK
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHH
SREGVPTPQEIMEVLDDYVIGQTYAKRVLSVAVHNHYKRLAHAGKNADVELSKSNILLIG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEE
PTGCGKTLLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQSADYNVERAQRG
CCCCCHHHHHHHHHHHHCCCCCHHCHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHCC
IVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVD
CEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHC
TSSILFICGGAFAGLEKIISDRGKKTSIGFGASVSSPEDRRAGELLRQVEPEDLLKFGLI
CCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCC
PEFVGRLPILATLEDLDEEALVQILTEPKNALVKQYQRLFEMENVELTFHENALRAIARK
HHHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHH
AIERKTGARGLRSIMEAILLDTMFELPALEGVQEVVISEDVVAGSARPLYIYAEREKEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
SVSA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA