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The map label for this gene is aapM [H]

Identifier: 110633468

GI number: 110633468

Start: 1218230

End: 1219726

Strand: Direct

Name: aapM [H]

Synonym: Meso_1115

Alternate gene names: 110633468

Gene position: 1218230-1219726 (Clockwise)

Preceding gene: 110633467

Following gene: 110633469

Centisome position: 27.61

GC content: 59.99

Gene sequence:

>1497_bases
ATGGAAGAACAGGTAGCAGCCTATGTCGCCCGTGAGCAGAAACAGCCGCTGCCGCCGCCTCCGAGCGAATTCGGCATCGT
GGCCACTTTCAGGAAAAACCTTTTTGCCACCCCGCTCGATTCAGTGATCACCATCGTGCTGGGGCTCTTCACCGCCTGGG
CAGCCTGGCGGCTTATCCAATGGGGAATTTCAGCAGCGGTTTTCACGGGTGGCAATCGGGAGGCCTGCCTGGCGACCGAG
GGCGGGGAAGTTGGCGCGTGCTGGGCGTTCGTTCGCGCCAAGCTTGGTCAATTCCTCTACGGAATTTATCCTTTGTCGCA
GCGCTGGCGTGTGGATCTTGTCTTTATCCTTCTCGTCGCCCTGATGTTGCCTCTTGCGATCCCGACTGCCCCCTTCAAAA
GGCTGAACGCCGTTCTGCTCGTACTCGTGCTTCCTTTTGTGGCGCTGGTTCTGCTTACCGGCGGCAATATCGGGATCAAT
GGTGGATGGGTGGCATTTCTTTTCACCCTGGCTGCCTTCGCCTCGCGTGTATTGGCTGCCGGCAATGTGAAGGCATCACC
GAACCTGTTGAAGACGGCGGGCAGTCTCGCACTGCTCGCGCTGGTCGTGCTCCTGGCCGCAAATTTCGTTTCGAGCGGTC
GAGTGACGCTTCTGGATTTCCGTTTCTCCACCCTTTCGCTTCTCGCTTTCCTGCTGGCGATCGGCTCCATCGCGGCGAGC
ATCCTTTCGGCACTCCGCGCGGGAGAGCCGCGCCATGCTTCGCCCCTGCGGGTTCTTGCGCCGCCGCTCCTATCGGCGGT
TTTGATAGCGGTGCTTGCTGCTGATTTCGGTCTCCAGCATGTTCCCACAAGTCAGTGGGGCGGGCTGATGCTTACCTTGG
TGGTGGCGCTTACCGGAATCGCCGCCTCGCTGCCGCTCGGCATCCTGCTGGCGCTGGGCAGGCGCTCGCATCTTCCCGCC
GTGCGGCTCTTCTCGATCATCTTCATCGAGTTCTGGCGCGGTGTTCCCCTGATTACCGTTCTCTTCATGTCGGCTTTCAT
GATCCCGCTGCTTCTGCCGGAGGGCGTGACCTTCAACCAGTTGCTCAGGGCACTGATCGGCGTCGCGATCTTCTCCGCGG
CCTATATGGCGGAGGTCATTCGCGGGGGGCTGCAGGCTATTCCGAAGGGCCAGTATGAAGGCGCGGAGGCGCTGGGCCTC
GGCTATTGGCAGATGATGCGGCTCGTGATCATGCCGCAGGCGATCAAGCTCGTGATACCGGGGATAGTGAATACCTTTAT
CGGCCTCTTCAAGGACACGAGCCTCGTTTACATCATCGGCCTTGCCGATCTTCTGGGAACAGTGCGCCGCGGCTTCTCGG
ATCCGAACTGGATCACGCCGACAACCGCAGCGACGGGCCTCGTATTTGCAGGTTTCGTCTATTGGCTCTTCTGCTTCGGC
ATGTCGCGCTACTCTATGTTCATGGAACGCCGGTTCGACACCGGTCACAAAAGATGA

Upstream 100 bases:

>100_bases
TCTGGATGGTTGTCTATCTGGGGCTGAGCGTCGCCACCGCGGCCTTCATGAACTGGTTCAACGCCCGCGTGGCGCTTGTG
GAGCGATAGGGGGCCGCGCG

Downstream 100 bases:

>100_bases
GGGAGAACACGATGTCGGCTGAAAATCTCACCGCTGCCGAGGGCATCCAGTTAGACCCTTCCAAGCTCAAGGTTTCGGAC
ACGGAGGTCGCGATCGAGAT

Product: polar amino acid ABC transporter, inner membrane subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MEEQVAAYVAREQKQPLPPPPSEFGIVATFRKNLFATPLDSVITIVLGLFTAWAAWRLIQWGISAAVFTGGNREACLATE
GGEVGACWAFVRAKLGQFLYGIYPLSQRWRVDLVFILLVALMLPLAIPTAPFKRLNAVLLVLVLPFVALVLLTGGNIGIN
GGWVAFLFTLAAFASRVLAAGNVKASPNLLKTAGSLALLALVVLLAANFVSSGRVTLLDFRFSTLSLLAFLLAIGSIAAS
ILSALRAGEPRHASPLRVLAPPLLSAVLIAVLAADFGLQHVPTSQWGGLMLTLVVALTGIAASLPLGILLALGRRSHLPA
VRLFSIIFIEFWRGVPLITVLFMSAFMIPLLLPEGVTFNQLLRALIGVAIFSAAYMAEVIRGGLQAIPKGQYEGAEALGL
GYWQMMRLVIMPQAIKLVIPGIVNTFIGLFKDTSLVYIIGLADLLGTVRRGFSDPNWITPTTAATGLVFAGFVYWLFCFG
MSRYSMFMERRFDTGHKR

Sequences:

>Translated_498_residues
MEEQVAAYVAREQKQPLPPPPSEFGIVATFRKNLFATPLDSVITIVLGLFTAWAAWRLIQWGISAAVFTGGNREACLATE
GGEVGACWAFVRAKLGQFLYGIYPLSQRWRVDLVFILLVALMLPLAIPTAPFKRLNAVLLVLVLPFVALVLLTGGNIGIN
GGWVAFLFTLAAFASRVLAAGNVKASPNLLKTAGSLALLALVVLLAANFVSSGRVTLLDFRFSTLSLLAFLLAIGSIAAS
ILSALRAGEPRHASPLRVLAPPLLSAVLIAVLAADFGLQHVPTSQWGGLMLTLVVALTGIAASLPLGILLALGRRSHLPA
VRLFSIIFIEFWRGVPLITVLFMSAFMIPLLLPEGVTFNQLLRALIGVAIFSAAYMAEVIRGGLQAIPKGQYEGAEALGL
GYWQMMRLVIMPQAIKLVIPGIVNTFIGLFKDTSLVYIIGLADLLGTVRRGFSDPNWITPTTAATGLVFAGFVYWLFCFG
MSRYSMFMERRFDTGHKR
>Mature_498_residues
MEEQVAAYVAREQKQPLPPPPSEFGIVATFRKNLFATPLDSVITIVLGLFTAWAAWRLIQWGISAAVFTGGNREACLATE
GGEVGACWAFVRAKLGQFLYGIYPLSQRWRVDLVFILLVALMLPLAIPTAPFKRLNAVLLVLVLPFVALVLLTGGNIGIN
GGWVAFLFTLAAFASRVLAAGNVKASPNLLKTAGSLALLALVVLLAANFVSSGRVTLLDFRFSTLSLLAFLLAIGSIAAS
ILSALRAGEPRHASPLRVLAPPLLSAVLIAVLAADFGLQHVPTSQWGGLMLTLVVALTGIAASLPLGILLALGRRSHLPA
VRLFSIIFIEFWRGVPLITVLFMSAFMIPLLLPEGVTFNQLLRALIGVAIFSAAYMAEVIRGGLQAIPKGQYEGAEALGL
GYWQMMRLVIMPQAIKLVIPGIVNTFIGLFKDTSLVYIIGLADLLGTVRRGFSDPNWITPTTAATGLVFAGFVYWLFCFG
MSRYSMFMERRFDTGHKR

Specific function: Part of a binding-protein-dependent transport system for L-amino acids, affects the uptake as well as efflux of these amino acids. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI87082239, Length=221, Percent_Identity=63.8009049773756, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1786873, Length=211, Percent_Identity=33.6492890995261, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=33.0143540669856, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787030, Length=157, Percent_Identity=33.1210191082803, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786874, Length=169, Percent_Identity=26.0355029585799, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788646, Length=222, Percent_Identity=26.1261261261261, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI48994930, Length=81, Percent_Identity=37.037037037037, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788645, Length=182, Percent_Identity=28.021978021978, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787087, Length=92, Percent_Identity=35.8695652173913, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 53699; Mature: 53699

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQVAAYVAREQKQPLPPPPSEFGIVATFRKNLFATPLDSVITIVLGLFTAWAAWRLIQ
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WGISAAVFTGGNREACLATEGGEVGACWAFVRAKLGQFLYGIYPLSQRWRVDLVFILLVA
HCCHHEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LMLPLAIPTAPFKRLNAVLLVLVLPFVALVLLTGGNIGINGGWVAFLFTLAAFASRVLAA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GNVKASPNLLKTAGSLALLALVVLLAANFVSSGRVTLLDFRFSTLSLLAFLLAIGSIAAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
ILSALRAGEPRHASPLRVLAPPLLSAVLIAVLAADFGLQHVPTSQWGGLMLTLVVALTGI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AASLPLGILLALGRRSHLPAVRLFSIIFIEFWRGVPLITVLFMSAFMIPLLLPEGVTFNQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHH
LLRALIGVAIFSAAYMAEVIRGGLQAIPKGQYEGAEALGLGYWQMMRLVIMPQAIKLVIP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIVNTFIGLFKDTSLVYIIGLADLLGTVRRGFSDPNWITPTTAATGLVFAGFVYWLFCFG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MSRYSMFMERRFDTGHKR
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEEQVAAYVAREQKQPLPPPPSEFGIVATFRKNLFATPLDSVITIVLGLFTAWAAWRLIQ
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
WGISAAVFTGGNREACLATEGGEVGACWAFVRAKLGQFLYGIYPLSQRWRVDLVFILLVA
HCCHHEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LMLPLAIPTAPFKRLNAVLLVLVLPFVALVLLTGGNIGINGGWVAFLFTLAAFASRVLAA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GNVKASPNLLKTAGSLALLALVVLLAANFVSSGRVTLLDFRFSTLSLLAFLLAIGSIAAS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
ILSALRAGEPRHASPLRVLAPPLLSAVLIAVLAADFGLQHVPTSQWGGLMLTLVVALTGI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AASLPLGILLALGRRSHLPAVRLFSIIFIEFWRGVPLITVLFMSAFMIPLLLPEGVTFNQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHH
LLRALIGVAIFSAAYMAEVIRGGLQAIPKGQYEGAEALGLGYWQMMRLVIMPQAIKLVIP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIVNTFIGLFKDTSLVYIIGLADLLGTVRRGFSDPNWITPTTAATGLVFAGFVYWLFCFG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MSRYSMFMERRFDTGHKR
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]