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The map label for this gene is gyaR [H]

Identifier: 110633434

GI number: 110633434

Start: 1183897

End: 1184829

Strand: Direct

Name: gyaR [H]

Synonym: Meso_1080

Alternate gene names: 110633434

Gene position: 1183897-1184829 (Clockwise)

Preceding gene: 110633433

Following gene: 110633435

Centisome position: 26.83

GC content: 61.63

Gene sequence:

>933_bases
ATGAGACCGGAGGTCATGGTGCGGATCCCATTGCCTTCCGCCGGGCTGAAGCTTTTGGAGGAAGATTTTGTCGTCCACTA
TGCGCCTTCGCCTGAGGAGTTCGAAAAGGCGATCGATGCGTATCCCGCCACGCGCGCCCTGGTCACGAATGGCTCGATCG
GTGTGACGGGAGACCAGCTCCGCCGGCTCAGAAAGCTGGAATTGGTGCACACGCAAGGGGTCGGCCATGAGAATGTCGAC
CTTGCGGCGGTGAAAGAGCTCGGATTGATCCTGTGCACAGGTAAGGGGACGAATGCGTCCTCCGTCGCGGACCACGCGAT
GGCGCTTCTCCTCGGGATCGCGCGCAACCTATCCTGGGCGGACCGGCAGGTCCGCAACGGGTTGTGGCTCAAGTCCCGCG
GGCCGCGTGCGCTTGCCTATCAAAAGCGTCTGGGCATTTTGGGGCTGGGCGAAATCGGCCTGCAGATCGCGGAGCGGGCC
CTAGGCTTCAACATGGAGATCCGTTACCACAACCGAAACAAGCGAAGCGATGTGCCGTATGAATATAAGGCCTCGCCGCT
CGAGCTCGCGCGCGACAGCGATTTCATCGTGATCGCCACGCCTGGAGGACCAGGCACGAAAGGCATCGTGAACCGCGAAT
TCCTGGATGCGCTCGGGCCCAAGGGATTCCTCATCAATATAGGCCGCGGTTCCATCGTGGATACGGACGAGCTGGTCAAG
GCGCTTCATGAGCAGCGGATCGCGGGCGCTGCCCTCGACGTGGTGGCGGGCGAGCCGAACGTCACCCAGGAATTGCTTGA
AGCGCCAAACCTGATCATCACACCGCACATGGCGGGCCGCTCGCCGGAAACCGTCTCGGCGGCGATGCAGCGCATTTCGA
ATAACCTCAAGGCGCATTTTGCCAATGGCGAGCTCGTTTCCCGGGTAGCCTAG

Upstream 100 bases:

>100_bases
CGTATGAAAAGCTCAAGGCGTCGGGCCTCCCGTTCGATAAGGAGTATCCGGAGATGTTGGCCGCGCTTGCGGCAGGCGGC
AATGCGGGAGAGAAGGCGGC

Downstream 100 bases:

>100_bases
CGCTGCGTCCAATCCCGCGCTAGGGGACCCCCATGGAGGAAGTTCAGTGTGTCGTTGCCGGTGCGGGTGTGATCGGGCTC
GCAGTCGCGCGTGCTTTGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRPEVMVRIPLPSAGLKLLEEDFVVHYAPSPEEFEKAIDAYPATRALVTNGSIGVTGDQLRRLRKLELVHTQGVGHENVD
LAAVKELGLILCTGKGTNASSVADHAMALLLGIARNLSWADRQVRNGLWLKSRGPRALAYQKRLGILGLGEIGLQIAERA
LGFNMEIRYHNRNKRSDVPYEYKASPLELARDSDFIVIATPGGPGTKGIVNREFLDALGPKGFLINIGRGSIVDTDELVK
ALHEQRIAGAALDVVAGEPNVTQELLEAPNLIITPHMAGRSPETVSAAMQRISNNLKAHFANGELVSRVA

Sequences:

>Translated_310_residues
MRPEVMVRIPLPSAGLKLLEEDFVVHYAPSPEEFEKAIDAYPATRALVTNGSIGVTGDQLRRLRKLELVHTQGVGHENVD
LAAVKELGLILCTGKGTNASSVADHAMALLLGIARNLSWADRQVRNGLWLKSRGPRALAYQKRLGILGLGEIGLQIAERA
LGFNMEIRYHNRNKRSDVPYEYKASPLELARDSDFIVIATPGGPGTKGIVNREFLDALGPKGFLINIGRGSIVDTDELVK
ALHEQRIAGAALDVVAGEPNVTQELLEAPNLIITPHMAGRSPETVSAAMQRISNNLKAHFANGELVSRVA
>Mature_310_residues
MRPEVMVRIPLPSAGLKLLEEDFVVHYAPSPEEFEKAIDAYPATRALVTNGSIGVTGDQLRRLRKLELVHTQGVGHENVD
LAAVKELGLILCTGKGTNASSVADHAMALLLGIARNLSWADRQVRNGLWLKSRGPRALAYQKRLGILGLGEIGLQIAERA
LGFNMEIRYHNRNKRSDVPYEYKASPLELARDSDFIVIATPGGPGTKGIVNREFLDALGPKGFLINIGRGSIVDTDELVK
ALHEQRIAGAALDVVAGEPNVTQELLEAPNLIITPHMAGRSPETVSAAMQRISNNLKAHFANGELVSRVA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=241, Percent_Identity=34.0248962655602, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI23308577, Length=262, Percent_Identity=29.3893129770992, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4557497, Length=245, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI145580575, Length=243, Percent_Identity=28.8065843621399, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082289, Length=294, Percent_Identity=31.2925170068027, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789279, Length=261, Percent_Identity=28.3524904214559, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787645, Length=270, Percent_Identity=24.4444444444444, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=168, Percent_Identity=30.3571428571429, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147481, Length=241, Percent_Identity=28.6307053941909, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=259, Percent_Identity=26.2548262548263, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=304, Percent_Identity=26.6447368421053, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=295, Percent_Identity=27.4576271186441, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=252, Percent_Identity=28.968253968254, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=265, Percent_Identity=26.7924528301887, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=241, Percent_Identity=30.7053941908714, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=30.8139534883721, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574286, Length=315, Percent_Identity=29.2063492063492, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571528, Length=254, Percent_Identity=33.0708661417323, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=242, Percent_Identity=32.2314049586777, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646446, Length=242, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=242, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=242, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=242, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574284, Length=238, Percent_Identity=30.2521008403361, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585514, Length=238, Percent_Identity=30.2521008403361, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574282, Length=238, Percent_Identity=30.2521008403361, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551003, Length=238, Percent_Identity=30.2521008403361, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552429, Length=238, Percent_Identity=30.2521008403361, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921140, Length=241, Percent_Identity=26.5560165975104, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585516, Length=300, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33594; Mature: 33594

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPEVMVRIPLPSAGLKLLEEDFVVHYAPSPEEFEKAIDAYPATRALVTNGSIGVTGDQL
CCCCEEEEECCCHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
RRLRKLELVHTQGVGHENVDLAAVKELGLILCTGKGTNASSVADHAMALLLGIARNLSWA
HHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHH
DRQVRNGLWLKSRGPRALAYQKRLGILGLGEIGLQIAERALGFNMEIRYHNRNKRSDVPY
HHHHHCCEEEECCCCCHHHHHHHCCEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
EYKASPLELARDSDFIVIATPGGPGTKGIVNREFLDALGPKGFLINIGRGSIVDTDELVK
EECCCHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCEECHHHHHH
ALHEQRIAGAALDVVAGEPNVTQELLEAPNLIITPHMAGRSPETVSAAMQRISNNLKAHF
HHHHHHHHCHHEEEECCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEE
ANGELVSRVA
CCCHHHHHCC
>Mature Secondary Structure
MRPEVMVRIPLPSAGLKLLEEDFVVHYAPSPEEFEKAIDAYPATRALVTNGSIGVTGDQL
CCCCEEEEECCCHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
RRLRKLELVHTQGVGHENVDLAAVKELGLILCTGKGTNASSVADHAMALLLGIARNLSWA
HHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHH
DRQVRNGLWLKSRGPRALAYQKRLGILGLGEIGLQIAERALGFNMEIRYHNRNKRSDVPY
HHHHHCCEEEECCCCCHHHHHHHCCEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
EYKASPLELARDSDFIVIATPGGPGTKGIVNREFLDALGPKGFLINIGRGSIVDTDELVK
EECCCHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEECCCCCEECHHHHHH
ALHEQRIAGAALDVVAGEPNVTQELLEAPNLIITPHMAGRSPETVSAAMQRISNNLKAHF
HHHHHHHHCHHEEEECCCCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEE
ANGELVSRVA
CCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA