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The map label for this gene is lhgO [H]

Identifier: 110633435

GI number: 110633435

Start: 1184862

End: 1185965

Strand: Direct

Name: lhgO [H]

Synonym: Meso_1081

Alternate gene names: 110633435

Gene position: 1184862-1185965 (Clockwise)

Preceding gene: 110633434

Following gene: 110633437

Centisome position: 26.85

GC content: 62.68

Gene sequence:

>1104_bases
ATGGAGGAAGTTCAGTGTGTCGTTGCCGGTGCGGGTGTGATCGGGCTCGCAGTCGCGCGTGCTTTGGCGTCGATGGGGCG
CGAAGTCATCATTCTTGAGGCCGCAGGCTCAATCGGCAGCGAAACCTCATCGCGAAACAGCGAGGTCATCCATGCCGGGA
TCTACTATCCGGCCGATAGCCTCATGGCGCGCCTCTGCGTGGAAGGGCGGCAACTGCTCTACGCCTATTGCCGAGAGCGC
GATATACCGCACCGGCAATGCGGAAAGCTGATCGTCGCGACGTCCAAGGCCGAACTGGAGCAACTGCCGGCAATTGCCGC
AAAGGCGGAACGGAACGGCGTTGCAGATTTGAGGCAGCTCACCGAATCCGAAGCCTGCTCCCTCGAACCGGCGCTGGCGA
CGGCCGGAGCATTACTGTCCCCGTCGACGGGCATCATCGACAGCCATGCCTATATGGTGTCGCTGCTGGGAGACGCGGAA
AGCGCCGGCGCCGTCCTCGTTCTAAACAGCCCGGTCGAGCGGGGGAGAGTGACCGATAAGGGCATCGTGCTCGATATCGG
CGGGTCCGATCCCACAACGCTCTCCTGCCGCCTGTTCGTGAATGCCGCGGGGCTTTCCGCGCCGAAGCTGGCGCGGAGCA
TCGAAGGAATGCCCGCGCAGCTTGTGCCGAAGGAATACCTTGCCAAGGGCGACTACTTCTCGCTTGCCGGCAAGGCGCCT
TTCTCGCGGCTCATCTACCCTGTTCCGGTCAAAGGCGGCCTTGGAATCCACCTGACGCTCGATCTTGCCGGACAGGCGCG
TTTCGGCCCGGACATCGAATGGGTAGACAACCTCCACTACGCGGTCGACCCCGCCAAGGCCGAGCTGTTCTATGCCGGGG
TGCGCCGGTATTTCCCCGACCTGAAGGATGGAGCGCTGCTTCCGGCCTATTCGGGTATCCGGCCGAAGATCGTGCCGCCG
GAGGTGGCGGTTCAGGATTTCCTCGTTCAAGGTCCACGGGCACACAGCGTCACCGGATTGATCAACCTCTTCGGCATCGA
GTCGCCCGGCCTGACATCCTCTCTCGCCTTGGCGAAGTTCGTTGCAGAAAGCCAGGCTGTGTAA

Upstream 100 bases:

>100_bases
TGCAGCGCATTTCGAATAACCTCAAGGCGCATTTTGCCAATGGCGAGCTCGTTTCCCGGGTAGCCTAGCGCTGCGTCCAA
TCCCGCGCTAGGGGACCCCC

Downstream 100 bases:

>100_bases
GGGCCGAAATGCCGGACCTAGCCTATCTCGCATCTATTGCTCAAGCCGCTTCGAAAAGTTGCACGATCTCCATTTCAGGC
ACGAGGACGAGCCCTTTGTC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MEEVQCVVAGAGVIGLAVARALASMGREVIILEAAGSIGSETSSRNSEVIHAGIYYPADSLMARLCVEGRQLLYAYCRER
DIPHRQCGKLIVATSKAELEQLPAIAAKAERNGVADLRQLTESEACSLEPALATAGALLSPSTGIIDSHAYMVSLLGDAE
SAGAVLVLNSPVERGRVTDKGIVLDIGGSDPTTLSCRLFVNAAGLSAPKLARSIEGMPAQLVPKEYLAKGDYFSLAGKAP
FSRLIYPVPVKGGLGIHLTLDLAGQARFGPDIEWVDNLHYAVDPAKAELFYAGVRRYFPDLKDGALLPAYSGIRPKIVPP
EVAVQDFLVQGPRAHSVTGLINLFGIESPGLTSSLALAKFVAESQAV

Sequences:

>Translated_367_residues
MEEVQCVVAGAGVIGLAVARALASMGREVIILEAAGSIGSETSSRNSEVIHAGIYYPADSLMARLCVEGRQLLYAYCRER
DIPHRQCGKLIVATSKAELEQLPAIAAKAERNGVADLRQLTESEACSLEPALATAGALLSPSTGIIDSHAYMVSLLGDAE
SAGAVLVLNSPVERGRVTDKGIVLDIGGSDPTTLSCRLFVNAAGLSAPKLARSIEGMPAQLVPKEYLAKGDYFSLAGKAP
FSRLIYPVPVKGGLGIHLTLDLAGQARFGPDIEWVDNLHYAVDPAKAELFYAGVRRYFPDLKDGALLPAYSGIRPKIVPP
EVAVQDFLVQGPRAHSVTGLINLFGIESPGLTSSLALAKFVAESQAV
>Mature_367_residues
MEEVQCVVAGAGVIGLAVARALASMGREVIILEAAGSIGSETSSRNSEVIHAGIYYPADSLMARLCVEGRQLLYAYCRER
DIPHRQCGKLIVATSKAELEQLPAIAAKAERNGVADLRQLTESEACSLEPALATAGALLSPSTGIIDSHAYMVSLLGDAE
SAGAVLVLNSPVERGRVTDKGIVLDIGGSDPTTLSCRLFVNAAGLSAPKLARSIEGMPAQLVPKEYLAKGDYFSLAGKAP
FSRLIYPVPVKGGLGIHLTLDLAGQARFGPDIEWVDNLHYAVDPAKAELFYAGVRRYFPDLKDGALLPAYSGIRPKIVPP
EVAVQDFLVQGPRAHSVTGLINLFGIESPGLTSSLALAKFVAESQAV

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=403, Percent_Identity=27.0471464019851, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI87082148, Length=384, Percent_Identity=26.5625, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17565764, Length=411, Percent_Identity=27.7372262773723, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24585081, Length=382, Percent_Identity=30.6282722513089, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38662; Mature: 38662

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEVQCVVAGAGVIGLAVARALASMGREVIILEAAGSIGSETSSRNSEVIHAGIYYPADS
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCHHH
LMARLCVEGRQLLYAYCRERDIPHRQCGKLIVATSKAELEQLPAIAAKAERNGVADLRQL
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHH
TESEACSLEPALATAGALLSPSTGIIDSHAYMVSLLGDAESAGAVLVLNSPVERGRVTDK
HHHHHCCCCHHHHHCCHHCCCCCCCCCCHHEEEEEECCCCCCCEEEEECCCHHHCCCCCC
GIVLDIGGSDPTTLSCRLFVNAAGLSAPKLARSIEGMPAQLVPKEYLAKGDYFSLAGKAP
CEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHCCCCHHCCCHHHHCCCCEEEECCCCC
FSRLIYPVPVKGGLGIHLTLDLAGQARFGPDIEWVDNLHYAVDPAKAELFYAGVRRYFPD
HHHCEEEECCCCCCEEEEEEEECCCCCCCCCCHHHCCCEEEECCHHHHHHHHHHHHHCCC
LKDGALLPAYSGIRPKIVPPEVAVQDFLVQGPRAHSVTGLINLFGIESPGLTSSLALAKF
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHEEEECCCCCCHHHHHHHHH
VAESQAV
HHHHCCC
>Mature Secondary Structure
MEEVQCVVAGAGVIGLAVARALASMGREVIILEAAGSIGSETSSRNSEVIHAGIYYPADS
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEEECCHHH
LMARLCVEGRQLLYAYCRERDIPHRQCGKLIVATSKAELEQLPAIAAKAERNGVADLRQL
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHH
TESEACSLEPALATAGALLSPSTGIIDSHAYMVSLLGDAESAGAVLVLNSPVERGRVTDK
HHHHHCCCCHHHHHCCHHCCCCCCCCCCHHEEEEEECCCCCCCEEEEECCCHHHCCCCCC
GIVLDIGGSDPTTLSCRLFVNAAGLSAPKLARSIEGMPAQLVPKEYLAKGDYFSLAGKAP
CEEEEECCCCCCEEEEEEEEEECCCCHHHHHHHHCCCCHHCCCHHHHCCCCEEEECCCCC
FSRLIYPVPVKGGLGIHLTLDLAGQARFGPDIEWVDNLHYAVDPAKAELFYAGVRRYFPD
HHHCEEEECCCCCCEEEEEEEECCCCCCCCCCHHHCCCEEEECCHHHHHHHHHHHHHCCC
LKDGALLPAYSGIRPKIVPPEVAVQDFLVQGPRAHSVTGLINLFGIESPGLTSSLALAKF
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHEEEECCCCCCHHHHHHHHH
VAESQAV
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]