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The map label for this gene is comE [H]

Identifier: 110633406

GI number: 110633406

Start: 1155665

End: 1156255

Strand: Direct

Name: comE [H]

Synonym: Meso_1052

Alternate gene names: 110633406

Gene position: 1155665-1156255 (Clockwise)

Preceding gene: 110633405

Following gene: 110633407

Centisome position: 26.19

GC content: 64.47

Gene sequence:

>591_bases
ATGCCCATGACCGAGAACACCCTCAACCGCCGCGAGGCCGTGAAGCGCATCCTGGCTGATCGTGGCGATACGCTCACCGT
CTCTTCGCTCGGCGGGCCCTCCTACGACGTGGCTGCCATCCAGGTGGACTTCGAGCAGGATTTTCCGCTGGGCGGAGCCA
TGGGGCAGGCGACGATGACCGGCCTGGGCCTCGCGCTTTCGCAGCCAAAGCGCCGCGTGATCGTGTTCGCGGGGGATGGC
GAGATGCTGATGAGCCTGGGTTCGCTCGCCACCATCGGAGCGGAAAAGCCGGACAATCTGGCCATCGTGGTGATCGACAA
TGAGCACTATGCCGAGACCGGCATGCAGCGCACCCACACCGGCCGCGGCATAGACCTTGCGGGTGTGGCGATCGGCTGTC
AATTTCCTGTTGTGCGCACGATCCGCACATCGGCAGAATTGGAAGAGGCGACGCCACTGATCCGCAGGGCGCCCGGTCCG
GTCTTCGCGCTGCTTAAGGTCAGCAACGAGGTCGGTCCGCTCTTTCCCCGCAACCGAGACGGCGTGTTCCAGAAGATGCA
GTTCCGCCGCGCCTTGCTTGGCAGGAGCTGA

Upstream 100 bases:

>100_bases
GAGACCGTGCGTGCCGGCCTCGCCATGGCCTTTTCCGCTCAGCAGGCGATTGCCGTCCTGTTGTCTCAGCGCCTGATCGG
CGCCAAGGTTTTCAAGTGAG

Downstream 100 bases:

>100_bases
AGGCCGATCGAAAGCATGATGTTCCATTTCCGCCGTCCGGCGGCACGAAACGAGGAGAAGACGACGTGGCGACGTACAAG
GCACCCTTGATGCTGATCGG

Product: thiamine pyrophosphate enzyme-like TPP-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MPMTENTLNRREAVKRILADRGDTLTVSSLGGPSYDVAAIQVDFEQDFPLGGAMGQATMTGLGLALSQPKRRVIVFAGDG
EMLMSLGSLATIGAEKPDNLAIVVIDNEHYAETGMQRTHTGRGIDLAGVAIGCQFPVVRTIRTSAELEEATPLIRRAPGP
VFALLKVSNEVGPLFPRNRDGVFQKMQFRRALLGRS

Sequences:

>Translated_196_residues
MPMTENTLNRREAVKRILADRGDTLTVSSLGGPSYDVAAIQVDFEQDFPLGGAMGQATMTGLGLALSQPKRRVIVFAGDG
EMLMSLGSLATIGAEKPDNLAIVVIDNEHYAETGMQRTHTGRGIDLAGVAIGCQFPVVRTIRTSAELEEATPLIRRAPGP
VFALLKVSNEVGPLFPRNRDGVFQKMQFRRALLGRS
>Mature_195_residues
PMTENTLNRREAVKRILADRGDTLTVSSLGGPSYDVAAIQVDFEQDFPLGGAMGQATMTGLGLALSQPKRRVIVFAGDGE
MLMSLGSLATIGAEKPDNLAIVVIDNEHYAETGMQRTHTGRGIDLAGVAIGCQFPVVRTIRTSAELEEATPLIRRAPGPV
FALLKVSNEVGPLFPRNRDGVFQKMQFRRALLGRS

Specific function: Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022494
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C [H]

EC number: =4.1.1.79 [H]

Molecular weight: Translated: 21123; Mature: 20992

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMTENTLNRREAVKRILADRGDTLTVSSLGGPSYDVAAIQVDFEQDFPLGGAMGQATMT
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCHHHH
GLGLALSQPKRRVIVFAGDGEMLMSLGSLATIGAEKPDNLAIVVIDNEHYAETGMQRTHT
HHHHEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHCCHHCCC
GRGIDLAGVAIGCQFPVVRTIRTSAELEEATPLIRRAPGPVFALLKVSNEVGPLFPRNRD
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEECCCCCCCCCCCCC
GVFQKMQFRRALLGRS
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PMTENTLNRREAVKRILADRGDTLTVSSLGGPSYDVAAIQVDFEQDFPLGGAMGQATMT
CCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCHHHH
GLGLALSQPKRRVIVFAGDGEMLMSLGSLATIGAEKPDNLAIVVIDNEHYAETGMQRTHT
HHHHEECCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHCCHHCCC
GRGIDLAGVAIGCQFPVVRTIRTSAELEEATPLIRRAPGPVFALLKVSNEVGPLFPRNRD
CCCEEEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEECCCCCCCCCCCCC
GVFQKMQFRRALLGRS
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10940029 [H]