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The map label for this gene is nuoI [H]

Identifier: 110633384

GI number: 110633384

Start: 1131835

End: 1132326

Strand: Direct

Name: nuoI [H]

Synonym: Meso_1030

Alternate gene names: 110633384

Gene position: 1131835-1132326 (Clockwise)

Preceding gene: 110633383

Following gene: 110633385

Centisome position: 25.65

GC content: 63.01

Gene sequence:

>492_bases
ATGTCAGCTCTTGCTCAAGCCGCCAAATCCCTTCTCCTGAAGGAGTTTTTTGGTGCAGTCGTGCTTTCCATGCGGCAGTT
CTTCGCGCCGAAGGCGACGCTGAACTATCCGCACGAGAAAGGACCGCTATCGCCCCGCTTCCGCGGCGAGCACGCGTTGC
GCCGCTACCCCAATGGCGAGGAGCGCTGCATCGCCTGCAAGCTCTGCGAGGCGATCTGCCCGGCGCAGGCCATCACCATC
GAGGCCGGGCCGCGCCGCAACGACGGCACGCGCCGTACCGTGCGGTACGATATCGACATGGTGAAGTGCATCTATTGCGG
CTTCTGCCAGGAGGCCTGCCCTGTGGATGCCATCGTGGAAGGACCGAATTTCGAGTTCGCGACGGAAACGCGCGAGGAAC
TCTATTACGACAAGGACAAGCTGCTTGCGAACGGCGACCGCTGGGAGCGCGAGCTTGCGCGCAACATCGCGCTCGACGCG
CCCTATCGCTGA

Upstream 100 bases:

>100_bases
CTGCCGATCTCGCTCTTCATGGTGGTTGCGACGGCGGCATTCCTGAAATTTACGGGGCTGGTATGAAGAGCCGCCCGTCC
AGATTCGCCGGAGAATGACG

Downstream 100 bases:

>100_bases
TAGGGGCGGCGGTGTCGCAGGAGTAGACGAGGGCGGGGCGCTCCTTTAAGAGAGCCGGCAATCAGGGCGGAACGGAAGGC
TGGGGCGGCAGCTCCGGCAA

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSALAQAAKSLLLKEFFGAVVLSMRQFFAPKATLNYPHEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITI
EAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNIALDA
PYR

Sequences:

>Translated_163_residues
MSALAQAAKSLLLKEFFGAVVLSMRQFFAPKATLNYPHEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITI
EAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNIALDA
PYR
>Mature_162_residues
SALAQAAKSLLLKEFFGAVVLSMRQFFAPKATLNYPHEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIE
AGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNIALDAP
YR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=162, Percent_Identity=72.2222222222222, Blast_Score=243, Evalue=5e-65,
Organism=Escherichia coli, GI1788617, Length=142, Percent_Identity=40.1408450704225, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555194, Length=160, Percent_Identity=68.125, Blast_Score=226, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17864306, Length=158, Percent_Identity=70.253164556962, Blast_Score=237, Evalue=2e-63,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18541; Mature: 18410

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALAQAAKSLLLKEFFGAVVLSMRQFFAPKATLNYPHEKGPLSPRFRGEHALRRYPNGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
ERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVE
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEC
GPNFEFATETREELYYDKDKLLANGDRWERELARNIALDAPYR
CCCCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SALAQAAKSLLLKEFFGAVVLSMRQFFAPKATLNYPHEKGPLSPRFRGEHALRRYPNGE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
ERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVE
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEC
GPNFEFATETREELYYDKDKLLANGDRWERELARNIALDAPYR
CCCCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]