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The map label for this gene is nuoH

Identifier: 110633383

GI number: 110633383

Start: 1130757

End: 1131800

Strand: Direct

Name: nuoH

Synonym: Meso_1029

Alternate gene names: 110633383

Gene position: 1130757-1131800 (Clockwise)

Preceding gene: 110633382

Following gene: 110633384

Centisome position: 25.63

GC content: 60.63

Gene sequence:

>1044_bases
ATGGAATCCTTTGTCACGCTCTACGTTCTTCCGGGGCTTCTGATCCTGCTGAAGTCGGTCGCGCTGATCGTCATCCTGCT
GGTGGGGGTCGCCTATATCCTTTACGCCGACCGCAAGATCTGGGCAGCGGTGCAGCTGCGCCGCGGTCCCAATGTGGTGG
GGCCGTGGGGCCTGTTTCAGGCTTTTGCGGATCTATTCAAGTTCGTGTTCAAGGAGCCGGTCATTCCTTCCGGCGCCAAC
AAGGGCGTGTTCCTGCTTGCGCCGGTGGTCGCTGCTGGCCTAGCGCTTGCTGCCTGGGCCGTTATTCCAGTCAGCGAAGG
CTGGGCAATAGCGAACATCAATGTGGGCATTCTCTATGTCTTCGCCATCGCTTCGCTCGAGGTCTATGGCGTGATCATGG
CCGGCTGGGCGTCGAACTCGAAATACCCGTTCCTGGGCGCGCTGCGCTCGGCGGCGCAGATGGTGTCCTACGAGGTTTCC
ATCGGCTTCGTCATCGTGACGGTGCTGCTCGCGGTGGGTTCGCTCAACCTGACCGATATTGTGCTCTCCCAGCGTGACGG
GCTCGGAACCATGGTGGGCCTGCCCAACTCCTTCCTCGACTGGCACTGGCTGGCGCTCTTCCCGATGTTCATCATCTTCT
TCATCTCCGCCCTGGCGGAGACGAACCGCCCGCCATTCGATCTCGTGGAGGCCGAATCGGAGCTGGTCGCCGGCCATATG
ATCGAGTATTCCTCGACGCCCTTCCTGCTCTTCTTCCTCGGCGAATATGTCGCCATCGTGCTGATGTGCGCGCTCACCAC
CATCCTCTTCCTCGGAGGCTGGCTGCCGCCTTTCGACTTCGCTCCCTTTACCTGGGTGCCAGGCGTGGTGTGGTTCGTGC
TCAAGCTGGTGGCCGTGTTCTTCATGTTCGCCCTGGTGAAATCCTTCGTGCCTCGCTACCGCTACGACCAGCTCATGCGG
CTCGGCTGGAAGGTCTTCCTGCCGATCTCGCTCTTCATGGTGGTTGCGACGGCGGCATTCCTGAAATTTACGGGGCTGGT
ATGA

Upstream 100 bases:

>100_bases
TCTCACCAACCCGATCGCGCGCGCATCCGCCATCATGGCGGAATGCTCCGCGCTTGCGCGTGGCGAATTGAAACAGGCGG
CCGAGTAGGGGCGAGAAACG

Downstream 100 bases:

>100_bases
AGAGCCGCCCGTCCAGATTCGCCGGAGAATGACGATGTCAGCTCTTGCTCAAGCCGCCAAATCCCTTCTCCTGAAGGAGT
TTTTTGGTGCAGTCGTGCTT

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MESFVTLYVLPGLLILLKSVALIVILLVGVAYILYADRKIWAAVQLRRGPNVVGPWGLFQAFADLFKFVFKEPVIPSGAN
KGVFLLAPVVAAGLALAAWAVIPVSEGWAIANINVGILYVFAIASLEVYGVIMAGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLAVGSLNLTDIVLSQRDGLGTMVGLPNSFLDWHWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
IEYSSTPFLLFFLGEYVAIVLMCALTTILFLGGWLPPFDFAPFTWVPGVVWFVLKLVAVFFMFALVKSFVPRYRYDQLMR
LGWKVFLPISLFMVVATAAFLKFTGLV

Sequences:

>Translated_347_residues
MESFVTLYVLPGLLILLKSVALIVILLVGVAYILYADRKIWAAVQLRRGPNVVGPWGLFQAFADLFKFVFKEPVIPSGAN
KGVFLLAPVVAAGLALAAWAVIPVSEGWAIANINVGILYVFAIASLEVYGVIMAGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLAVGSLNLTDIVLSQRDGLGTMVGLPNSFLDWHWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
IEYSSTPFLLFFLGEYVAIVLMCALTTILFLGGWLPPFDFAPFTWVPGVVWFVLKLVAVFFMFALVKSFVPRYRYDQLMR
LGWKVFLPISLFMVVATAAFLKFTGLV
>Mature_347_residues
MESFVTLYVLPGLLILLKSVALIVILLVGVAYILYADRKIWAAVQLRRGPNVVGPWGLFQAFADLFKFVFKEPVIPSGAN
KGVFLLAPVVAAGLALAAWAVIPVSEGWAIANINVGILYVFAIASLEVYGVIMAGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLAVGSLNLTDIVLSQRDGLGTMVGLPNSFLDWHWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
IEYSSTPFLLFFLGEYVAIVLMCALTTILFLGGWLPPFDFAPFTWVPGVVWFVLKLVAVFFMFALVKSFVPRYRYDQLMR
LGWKVFLPISLFMVVATAAFLKFTGLV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=303, Percent_Identity=40.9240924092409, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1788618, Length=327, Percent_Identity=41.8960244648318, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1789077, Length=298, Percent_Identity=26.8456375838926, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_MESSB (Q11JJ9)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673591.1
- STRING:   Q11JJ9
- GeneID:   4180387
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1029
- NMPDR:   fig|266779.1.peg.2552
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q11JJ9
- ProtClustDB:   PRK06076
- BioCyc:   MSP266779:MESO_1029-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38204; Mature: 38204

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17de61a0)-; HASH(0x17856c88)-; HASH(0x17518a2c)-; HASH(0x177cf754)-; HASH(0x124a1b90)-; HASH(0x13debfb8)-; HASH(0x19010008)-; HASH(0x17d18d54)-; HASH(0x12577614)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFVTLYVLPGLLILLKSVALIVILLVGVAYILYADRKIWAAVQLRRGPNVVGPWGLFQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHH
AFADLFKFVFKEPVIPSGANKGVFLLAPVVAAGLALAAWAVIPVSEGWAIANINVGILYV
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHH
FAIASLEVYGVIMAGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLAVGSLNLTDI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VLSQRDGLGTMVGLPNSFLDWHWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IEYSSTPFLLFFLGEYVAIVLMCALTTILFLGGWLPPFDFAPFTWVPGVVWFVLKLVAVF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FMFALVKSFVPRYRYDQLMRLGWKVFLPISLFMVVATAAFLKFTGLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MESFVTLYVLPGLLILLKSVALIVILLVGVAYILYADRKIWAAVQLRRGPNVVGPWGLFQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHH
AFADLFKFVFKEPVIPSGANKGVFLLAPVVAAGLALAAWAVIPVSEGWAIANINVGILYV
HHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHEECCCCEEEEECCHHHHHH
FAIASLEVYGVIMAGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLAVGSLNLTDI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VLSQRDGLGTMVGLPNSFLDWHWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IEYSSTPFLLFFLGEYVAIVLMCALTTILFLGGWLPPFDFAPFTWVPGVVWFVLKLVAVF
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FMFALVKSFVPRYRYDQLMRLGWKVFLPISLFMVVATAAFLKFTGLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA