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The map label for this gene is nuoD

Identifier: 110633379

GI number: 110633379

Start: 1125066

End: 1126256

Strand: Direct

Name: nuoD

Synonym: Meso_1025

Alternate gene names: 110633379

Gene position: 1125066-1126256 (Clockwise)

Preceding gene: 110633378

Following gene: 110633380

Centisome position: 25.5

GC content: 62.22

Gene sequence:

>1191_bases
GTGGCTGAAACCTCCATCCGCAACTTCAATATCAATTTCGGCCCGCAGCATCCGGCCGCGCACGGCGTGCTTCGTCTTGT
TCTGGAGCTCGACGGCGAGGTGGTGGAGCGCGTGGATCCCCATATCGGGCTGCTCCACCGCGGCACCGAAAAGCTGATCG
AGTATAAGACCTACCTGCAGGCGATCCCGTATTTCGACCGGCTCGACTATGTCGCGCCGATGAACCAGGAGCATGCCTTC
GCGCTGGCGATCGAGCGGTTGCTGGGCATTGACGTGCCTATCCGTGGCCAGCTCATCCGTGTTCTCTATTCCGAGATCAG
CCGCATCCTGAACCACCTGCTCAACATCACCACGCAGGCGATGGACGTCGGTGCGCTCACCCCGCCGCTGTGGGGGTTCG
AGGAGCGCGAGAAGCTGATGGTCTTCTACGAGCGGGCTTCCGGCGCCCGCATGCACGCGGCCTATTTCCGGCCCGGCGGT
GTGCACCAGGACCTGCCGGAAAAGCTGGTGGAGGATATCGGCAAGTGGATCGATCCGTTCCTGAAGACGGTCGACGATCT
CGATGAACTCCTGACCGAGAACCGGATCTTCAAGCAGCGCAACGCCGATATCGGAATCGTGTCGCTCGAGGATGCCTGGG
CCTGGGGCTTTTCGGGCGTGATGGTGCGCGGCTCCGGCGCGGCCTGGGACCTGCGCAAGAGCCAGCCCTACGAGTGCTAC
CCGGAGATGGATTTCGACATCCCTGTGGGCAAGAATGGCGACTGCTACGACCGCTATCTCATCCGCATGGAGGAGATGCG
CCAGTCGGCCAAGATCATGCGGCAATGCGTTGAGCGTCTGCTCGGCAAGGAGCGCGTTGGCCCCGTCTCGAACATGGACG
GCAAGGTCGTGCCGCCGAAGCGCGCCGCCATGAAGCGATCGATGGAATCGCTCATCCATCACTTCAAGCTCTATACGGAA
GGCTATCACGTGCCGGCCGGCGAGGTTTACGCGGCCGTCGAGGCGCCGAAAGGCGAGTTCGGCGTCTATCTCGTGGCCGA
CGGCACCAACAAGCCCTACCGCTGCAAGCTGCGCGCGCCGGGCTTCGCTCATCTTCAGGCCATGGATTTCATGTGCCGCG
GCCATCTTCTTGCCGACGTAACCGCCGTGCTCGGCTCCCTCGATATCGTGTTTGGTGAGGTAGACAGATAA

Upstream 100 bases:

>100_bases
GCAGGAATTCAGAAATTTCGACTTTTTGTCTCCATGGGAGGGAACCGATTACGTCCTTCCTGGCGATGAAAAAGCAAAGC
AGTGATCGGGAAGGTGTCGC

Downstream 100 bases:

>100_bases
TGGCAGTCCGCCGTCTCGCAGACGAAGCCGTCCAGCCCCAGGGCTTTGCCTTCACCAGGGAAAACGAGGCCTGGGCGCAT
CATACGATCCGCAAATACCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAETSIRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQAIPYFDRLDYVAPMNQEHAF
ALAIERLLGIDVPIRGQLIRVLYSEISRILNHLLNITTQAMDVGALTPPLWGFEEREKLMVFYERASGARMHAAYFRPGG
VHQDLPEKLVEDIGKWIDPFLKTVDDLDELLTENRIFKQRNADIGIVSLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
PEMDFDIPVGKNGDCYDRYLIRMEEMRQSAKIMRQCVERLLGKERVGPVSNMDGKVVPPKRAAMKRSMESLIHHFKLYTE
GYHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRCKLRAPGFAHLQAMDFMCRGHLLADVTAVLGSLDIVFGEVDR

Sequences:

>Translated_396_residues
MAETSIRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQAIPYFDRLDYVAPMNQEHAF
ALAIERLLGIDVPIRGQLIRVLYSEISRILNHLLNITTQAMDVGALTPPLWGFEEREKLMVFYERASGARMHAAYFRPGG
VHQDLPEKLVEDIGKWIDPFLKTVDDLDELLTENRIFKQRNADIGIVSLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
PEMDFDIPVGKNGDCYDRYLIRMEEMRQSAKIMRQCVERLLGKERVGPVSNMDGKVVPPKRAAMKRSMESLIHHFKLYTE
GYHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRCKLRAPGFAHLQAMDFMCRGHLLADVTAVLGSLDIVFGEVDR
>Mature_395_residues
AETSIRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQAIPYFDRLDYVAPMNQEHAFA
LAIERLLGIDVPIRGQLIRVLYSEISRILNHLLNITTQAMDVGALTPPLWGFEEREKLMVFYERASGARMHAAYFRPGGV
HQDLPEKLVEDIGKWIDPFLKTVDDLDELLTENRIFKQRNADIGIVSLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECYP
EMDFDIPVGKNGDCYDRYLIRMEEMRQSAKIMRQCVERLLGKERVGPVSNMDGKVVPPKRAAMKRSMESLIHHFKLYTEG
YHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRCKLRAPGFAHLQAMDFMCRGHLLADVTAVLGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=394, Percent_Identity=64.9746192893401, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI260898743, Length=388, Percent_Identity=64.1752577319588, Blast_Score=517, Evalue=1e-147,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=39.5348837209302, Blast_Score=294, Evalue=9e-81,
Organism=Escherichia coli, GI1789076, Length=391, Percent_Identity=25.3196930946292, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788832, Length=388, Percent_Identity=25.7731958762887, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=63.7055837563452, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=62.9441624365482, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=62.4365482233503, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221459469, Length=394, Percent_Identity=55.5837563451777, Blast_Score=477, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_MESSB (Q11JK3)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673587.1
- ProteinModelPortal:   Q11JK3
- SMR:   Q11JK3
- STRING:   Q11JK3
- GeneID:   4180383
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1025
- NMPDR:   fig|266779.1.peg.2556
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MADVITI
- PhylomeDB:   Q11JK3
- ProtClustDB:   PRK06075
- BioCyc:   MSP266779:MESO_1025-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 44906; Mature: 44775

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00535 COMPLEX1_49K; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETSIRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQ
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHHHH
AIPYFDRLDYVAPMNQEHAFALAIERLLGIDVPIRGQLIRVLYSEISRILNHLLNITTQA
HCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMVFYERASGARMHAAYFRPGGVHQDLPEKLVEDIGKWIDPF
HHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LKTVDDLDELLTENRIFKQRNADIGIVSLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCEEEECCCCEEECCCCCCCCCC
PEMDFDIPVGKNGDCYDRYLIRMEEMRQSAKIMRQCVERLLGKERVGPVSNMDGKVVPPK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCH
RAAMKRSMESLIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRCKLRAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQAMDFMCRGHLLADVTAVLGSLDIVFGEVDR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
AETSIRNFNINFGPQHPAAHGVLRLVLELDGEVVERVDPHIGLLHRGTEKLIEYKTYLQ
CCCCCEEEECCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHCCHHHHHHHHHHHH
AIPYFDRLDYVAPMNQEHAFALAIERLLGIDVPIRGQLIRVLYSEISRILNHLLNITTQA
HCCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEEREKLMVFYERASGARMHAAYFRPGGVHQDLPEKLVEDIGKWIDPF
HHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LKTVDDLDELLTENRIFKQRNADIGIVSLEDAWAWGFSGVMVRGSGAAWDLRKSQPYECY
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCEEEECCCCEEECCCCCCCCCC
PEMDFDIPVGKNGDCYDRYLIRMEEMRQSAKIMRQCVERLLGKERVGPVSNMDGKVVPPK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCCH
RAAMKRSMESLIHHFKLYTEGYHVPAGEVYAAVEAPKGEFGVYLVADGTNKPYRCKLRAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQAMDFMCRGHLLADVTAVLGSLDIVFGEVDR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA