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The map label for this gene is thrS

Identifier: 110633361

GI number: 110633361

Start: 1103527

End: 1105497

Strand: Direct

Name: thrS

Synonym: Meso_1007

Alternate gene names: 110633361

Gene position: 1103527-1105497 (Clockwise)

Preceding gene: 110633360

Following gene: 110633365

Centisome position: 25.01

GC content: 61.54

Gene sequence:

>1971_bases
ATGGCTGAAGCCGCTTCCCTGACATTCCCCGATGGCTCCGTCCGCAATGTCGATGCGGCGATGACCGGAGCCGACATTGC
AGAATCCATATCGAAATCGCTGGCCAAGAAGGCCGTCGCCTATGCCATGGACGGCTCCCTGCGCGATCTATCCGATCCCG
TTGAGCGCAGCGGCAAGATAGAGATCATCACGCGCGAGGACCCGCGCGCGCTGGAGCTTATCAGGCACGACGCGGCGCAT
GTGCTGGCCGAAGCCGTGCAGGAATTGTGGCCGGGCACCCAGGTGACCATCGGCCCGGTGATCGAGAACGGCTTCTATTA
CGATTTCGCCCGCAATGAGCCCTTCACGCTGGATGACCTGCCGGTTATCGAGAAGAAGATGCGGGAGATCGTCGACCGCA
ATAAGCGGTTTTCCAAGGAAGTCTGGCCGCGCGACAAGGCGAAGAAGGTTTTTGCCGACAAGGGCGAGAGCTACAAGGTC
GAGCTGATCGACGCCATCCCGGAAGACCAGGACCTGAAAATCTACTTTCAGGGCGATTGGTTCGATCTCTGCCGCGGCCC
GCACATGGCCTCGACCGGCCAGATCGGCAAGGCGTTCAAGCTGATGAAGGTTGCCGGCGCCTATTGGCGCGGCGATTCCA
ACCGCCCGATGCTGACGCGCATCTACGGTACTGCCTGGGCGGACCAGCAGCAGCTCGACTCTTATCTGCAGATGCTGGAG
GAGGCGGAAAAGCGCGATCATCGCCGCCTCGGCCGCGAGATGGACCTGTTCCATTTCCAGGAGGAGGGGCCGGGCGTCGT
CTTCTGGCACGCCAAGGGCTGGCGCATGTTCCAGAACCTTGTCTCCTACATGCGCCGCCGGCTCGACGGTGTGTATCAGG
AGGTGAATGCGCCGCAGGTGCTCGACCATTCCCTGTGGCAGACCTCAGGCCACTGGGGCTGGTACAAGGAGAACATGTTC
AAGGTCGAGTGCGCCGACGAGGAGGCGGAGGACAAGCGCACCTTCGCGCTGAAGCCGATGAACTGCCCCGGCCATGTGCA
GATCTTCAAGCATGGCCTGAAGTCCTACCGCGACCTGCCGATCCGCCTTGCCGAATTTGGCGCCGTTCACCGCTATGAGC
CTTCGGGCGCCTTGCATGGGCTGATGCGCGTGCGCGGCTTCACACAGGACGATGCGCATATCTTCTGCACGGAAGATCAG
CTCGCCGAGGAGTGCCTCAAGATCAACGATCTGATCCTCTCCACCTATGCCGATTTCGGCTTCGAGGAGATTCAGGTCTT
CTTCTCCACGCGGCCTGAGAAGCGCGTGGGCTCCGATGCGCTCTGGGATCACGCGGAAGAGATCATGGGCGGCGTCTTGG
AGCAGATTGCGGAACGTTCGGGAGGACGCATCAAGACCGCGATCAATCCGGGAGACGGTGCCTTCTACGGTCCGAAATTC
GATTACGTGCTGAAAGATGCCATTGGCCGCCAGTGGCAGTGCGGCACGACACAGGTGGATTTCAACCTGCCGGAGCGCTT
CGGCGCCTTCTACATCGACAAGGATTCGGAGAAGAAACAGCCGGTGATGATCCATCGCGCCATCTGCGGCTCGATGGAGC
GCTTCCTCGGCATCCTGATCGAGAACTATGCGGGACACTTCCCGCTATGGTTCGCGCCGTTGCAGGTGGTGGTGGCAACG
ATCACGTCGGACGCCGACGACTATGCCCGGCAGGTGACCCAGCAACTGAAAGCGGCAGGCCTTACCGCCGAGGCCGACTT
GCGCAACGAGAAGATCAACTACAAGGTCCGCGAGCACAGCCTCGCAAAGGTGCCGGTCATCCTCGTTTGCGGCAAGCGCG
AGGCGGAGGAAGGCAGCGTGAACATCCGCCGGCTCGGCAGCCGGGATCAAGCGTCATTGCTCCTGGCGGAAGCGATTGCC
CAGCTGATCGACGAGGCTACCCCGCCCGACATTCGGCGGGCCAAGGCTTAG

Upstream 100 bases:

>100_bases
ACTGGGGGCTTGCCGATCCCCCTCTATCCCGCTAGATGCGACAGCCTTGATTGTCTTTCACCACCCGCGCTCGTTGGCGG
GACTGGATAAGGAGATTCCA

Downstream 100 bases:

>100_bases
TGAGGGCGCCGGCAAAGCCGGCGCTTTCATCACGCCGTAGAGTCATAAGCCGCAGAATGTGCCGGTCGGCGAGCGACCGC
ATTATCGCCGTTCGTATTGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MAEAASLTFPDGSVRNVDAAMTGADIAESISKSLAKKAVAYAMDGSLRDLSDPVERSGKIEIITREDPRALELIRHDAAH
VLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTLDDLPVIEKKMREIVDRNKRFSKEVWPRDKAKKVFADKGESYKV
ELIDAIPEDQDLKIYFQGDWFDLCRGPHMASTGQIGKAFKLMKVAGAYWRGDSNRPMLTRIYGTAWADQQQLDSYLQMLE
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWRMFQNLVSYMRRRLDGVYQEVNAPQVLDHSLWQTSGHWGWYKENMF
KVECADEEAEDKRTFALKPMNCPGHVQIFKHGLKSYRDLPIRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHIFCTEDQ
LAEECLKINDLILSTYADFGFEEIQVFFSTRPEKRVGSDALWDHAEEIMGGVLEQIAERSGGRIKTAINPGDGAFYGPKF
DYVLKDAIGRQWQCGTTQVDFNLPERFGAFYIDKDSEKKQPVMIHRAICGSMERFLGILIENYAGHFPLWFAPLQVVVAT
ITSDADDYARQVTQQLKAAGLTAEADLRNEKINYKVREHSLAKVPVILVCGKREAEEGSVNIRRLGSRDQASLLLAEAIA
QLIDEATPPDIRRAKA

Sequences:

>Translated_656_residues
MAEAASLTFPDGSVRNVDAAMTGADIAESISKSLAKKAVAYAMDGSLRDLSDPVERSGKIEIITREDPRALELIRHDAAH
VLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTLDDLPVIEKKMREIVDRNKRFSKEVWPRDKAKKVFADKGESYKV
ELIDAIPEDQDLKIYFQGDWFDLCRGPHMASTGQIGKAFKLMKVAGAYWRGDSNRPMLTRIYGTAWADQQQLDSYLQMLE
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWRMFQNLVSYMRRRLDGVYQEVNAPQVLDHSLWQTSGHWGWYKENMF
KVECADEEAEDKRTFALKPMNCPGHVQIFKHGLKSYRDLPIRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHIFCTEDQ
LAEECLKINDLILSTYADFGFEEIQVFFSTRPEKRVGSDALWDHAEEIMGGVLEQIAERSGGRIKTAINPGDGAFYGPKF
DYVLKDAIGRQWQCGTTQVDFNLPERFGAFYIDKDSEKKQPVMIHRAICGSMERFLGILIENYAGHFPLWFAPLQVVVAT
ITSDADDYARQVTQQLKAAGLTAEADLRNEKINYKVREHSLAKVPVILVCGKREAEEGSVNIRRLGSRDQASLLLAEAIA
QLIDEATPPDIRRAKA
>Mature_655_residues
AEAASLTFPDGSVRNVDAAMTGADIAESISKSLAKKAVAYAMDGSLRDLSDPVERSGKIEIITREDPRALELIRHDAAHV
LAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTLDDLPVIEKKMREIVDRNKRFSKEVWPRDKAKKVFADKGESYKVE
LIDAIPEDQDLKIYFQGDWFDLCRGPHMASTGQIGKAFKLMKVAGAYWRGDSNRPMLTRIYGTAWADQQQLDSYLQMLEE
AEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWRMFQNLVSYMRRRLDGVYQEVNAPQVLDHSLWQTSGHWGWYKENMFK
VECADEEAEDKRTFALKPMNCPGHVQIFKHGLKSYRDLPIRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHIFCTEDQL
AEECLKINDLILSTYADFGFEEIQVFFSTRPEKRVGSDALWDHAEEIMGGVLEQIAERSGGRIKTAINPGDGAFYGPKFD
YVLKDAIGRQWQCGTTQVDFNLPERFGAFYIDKDSEKKQPVMIHRAICGSMERFLGILIENYAGHFPLWFAPLQVVVATI
TSDADDYARQVTQQLKAAGLTAEADLRNEKINYKVREHSLAKVPVILVCGKREAEEGSVNIRRLGSRDQASLLLAEAIAQ
LIDEATPPDIRRAKA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=649, Percent_Identity=39.5993836671803, Blast_Score=461, Evalue=1e-129,
Organism=Homo sapiens, GI38570111, Length=625, Percent_Identity=39.04, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI20070344, Length=656, Percent_Identity=37.1951219512195, Blast_Score=421, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=641, Percent_Identity=50.390015600624, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=636, Percent_Identity=40.8805031446541, Blast_Score=473, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984192, Length=636, Percent_Identity=40.8805031446541, Blast_Score=472, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=662, Percent_Identity=39.7280966767372, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6322654, Length=418, Percent_Identity=36.3636363636364, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24583839, Length=647, Percent_Identity=39.1035548686244, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583842, Length=647, Percent_Identity=39.1035548686244, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI28574141, Length=647, Percent_Identity=39.1035548686244, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_MESSB (Q11JM1)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673569.1
- ProteinModelPortal:   Q11JM1
- SMR:   Q11JM1
- STRING:   Q11JM1
- GeneID:   4180521
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_1007
- NMPDR:   fig|266779.1.peg.3978
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- PhylomeDB:   Q11JM1
- ProtClustDB:   PRK00413
- BioCyc:   MSP266779:MESO_1007-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74484; Mature: 74353

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAASLTFPDGSVRNVDAAMTGADIAESISKSLAKKAVAYAMDGSLRDLSDPVERSGKI
CCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHCCCCE
EIITREDPRALELIRHDAAHVLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTLDDL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCC
PVIEKKMREIVDRNKRFSKEVWPRDKAKKVFADKGESYKVELIDAIPEDQDLKIYFQGDW
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCH
FDLCRGPHMASTGQIGKAFKLMKVAGAYWRGDSNRPMLTRIYGTAWADQQQLDSYLQMLE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWRMFQNLVSYMRRRLDGVYQEVNAPQV
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
LDHSLWQTSGHWGWYKENMFKVECADEEAEDKRTFALKPMNCPGHVQIFKHGLKSYRDLP
HHHHHHHCCCCCCEECCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCC
IRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHIFCTEDQLAEECLKINDLILSTYADFG
HHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCC
FEEIQVFFSTRPEKRVGSDALWDHAEEIMGGVLEQIAERSGGRIKTAINPGDGAFYGPKF
HHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCH
DYVLKDAIGRQWQCGTTQVDFNLPERFGAFYIDKDSEKKQPVMIHRAICGSMERFLGILI
HHHHHHHCCCCEECCCEEEECCCHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ENYAGHFPLWFAPLQVVVATITSDADDYARQVTQQLKAAGLTAEADLRNEKINYKVREHS
HHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEECCCC
LAKVPVILVCGKREAEEGSVNIRRLGSRDQASLLLAEAIAQLIDEATPPDIRRAKA
CCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure 
AEAASLTFPDGSVRNVDAAMTGADIAESISKSLAKKAVAYAMDGSLRDLSDPVERSGKI
CCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHCCCCE
EIITREDPRALELIRHDAAHVLAEAVQELWPGTQVTIGPVIENGFYYDFARNEPFTLDDL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCCC
PVIEKKMREIVDRNKRFSKEVWPRDKAKKVFADKGESYKVELIDAIPEDQDLKIYFQGDW
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCH
FDLCRGPHMASTGQIGKAFKLMKVAGAYWRGDSNRPMLTRIYGTAWADQQQLDSYLQMLE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
EAEKRDHRRLGREMDLFHFQEEGPGVVFWHAKGWRMFQNLVSYMRRRLDGVYQEVNAPQV
HHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
LDHSLWQTSGHWGWYKENMFKVECADEEAEDKRTFALKPMNCPGHVQIFKHGLKSYRDLP
HHHHHHHCCCCCCEECCCEEEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCC
IRLAEFGAVHRYEPSGALHGLMRVRGFTQDDAHIFCTEDQLAEECLKINDLILSTYADFG
HHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCC
FEEIQVFFSTRPEKRVGSDALWDHAEEIMGGVLEQIAERSGGRIKTAINPGDGAFYGPKF
HHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCH
DYVLKDAIGRQWQCGTTQVDFNLPERFGAFYIDKDSEKKQPVMIHRAICGSMERFLGILI
HHHHHHHCCCCEECCCEEEECCCHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
ENYAGHFPLWFAPLQVVVATITSDADDYARQVTQQLKAAGLTAEADLRNEKINYKVREHS
HHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEECCCC
LAKVPVILVCGKREAEEGSVNIRRLGSRDQASLLLAEAIAQLIDEATPPDIRRAKA
CCCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA