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The map label for this gene is degP [H]

Identifier: 110633255

GI number: 110633255

Start: 991362

End: 992891

Strand: Direct

Name: degP [H]

Synonym: Meso_0901

Alternate gene names: 110633255

Gene position: 991362-992891 (Clockwise)

Preceding gene: 110633254

Following gene: 110633256

Centisome position: 22.47

GC content: 63.59

Gene sequence:

>1530_bases
ATGAGCGAAGAGCAGAACGTAACCTCCAAAAAAATAACTTCCAAGACCCGCAATCGCCTCGTGGCGGCCGTGGCCTCTGC
GGCTATAGCCGGTGCGGTCGGTTTTAGCGCAATAAGTTCGGGCACCGTCCCGGTGTTCGCTGAGCCGGTGAAGCTGGACA
GGCCCGTTCAGGCGCCCAGTTTTGCCGATGTGGTCGATGTCGTCACACCCGCGGTGGTGAGCGTGCGCATTTCGGGTGAA
GCGCCGGAGACGGGCACGGTGGCGACGCCGTTCTTCGACATGCCGGGCTTTGACAATCTTCCGCCGAACCATCCGTTGCG
CCGTTTCTTCGATGAGTTCCAGAGGCGTGACGAGCAGCCGCGCGGCCCGCAGCAGCGCCGGCGCACCCGGCCGGTTGCCC
AAGGTTCCGGGTTCTTCATCTCCGGTGACGGCTATATCGTCACCAACAACCATGTGGTCGAAGGTGGAAATCAGTACACG
GTCGTTCTGGAGGACGGCACCGAGCTGCAGGCCGATCTGATCGGCAAGGACCCCCGCACCGATCTGGCGGTACTCAAGGT
TAAAGCCGACCGCGAGTTCACCTATGTGACCTGGGCCAATGACGATGCGGCACGCGTGGGCGACTGGGTGGTTGCCGTGG
GCAACCCGTTCGGGCTCGGCGGTACGGTGACGGCGGGCATCGTTTCGGCCCGAGGCCGTGAGATCGGCGCCGGGAATTAC
GATGACTTCCTGCAGATCGACGCGGCGGTGAATCAGGGCAACTCCGGCGGGCCGACCTTCAACCTCGCCGGTGAGGTGGT
TGGCGTCAACACCGCGATTTTCTCGCCCTCCGGCGGCAATGTCGGCATTGCCTTCGCAATTCCGGCTTCCCTTGCCAAGA
CGGTCGTAGAGCAGCTTATCGAGGATGGTTCCGTCGAGCGCGGCTATATGGGAGTCAGCATCCAGGAGGTGACACCCCAG
ATCGCGGAGTCGCTTGGCCTGCAGGACGCAAGGGGCGCGCTGATCAACAGCGCGAACAGCGGCGATCCCGCAGCCAGGGC
AGGTATTCAAGCCGGTGACGTCGTTATCGCAGTGAACGGCAAGACCATCGCCACCCCCCGCGAGTTGGCTCGCACGGTGG
CGGCTATCCAGCCTGGCACCGAGATCGATGTTACGGTGTGGCGCAACGGTAAGTCGCAGGATTTTTCCGTGACGTTGACG
GAGATGCCTGACACTGACCAGGTCGCTTCGGCGGCGCCCAGCGCGCCCTCGCAGGATGAGGGCGGTCAGCCGGCAAGCTT
TGGATTGACGGTTGCACCGGCCGATGACGGCAATGGCCTCGTCGTCACCGATGTCGAGCCGGGCAGCGTGGCGGAGGAGA
ACGGAATCCAGCCGGGAGACGTGATCCGCGCCATCAATTCTCAGCCCGTAACAACGGCGGGCGACCTCAAGAAGGCTGCT
GATGCGGCATCGAGTGCCGGCCGTGGCGCAGTGCTCCTGCAGGTCGTGCGTGATGACGCTAACCGCTTCGTCGCGCTGCC
AATTGGCTGA

Upstream 100 bases:

>100_bases
TTGGAAATGGCATCGTAAGGTACTCAGTCCTATTTCAATGGCGGAACGGGACGAGGATGCGTCCCCCGAGTGGATCCAAG
GTATGAGGAGTTGGTTCGTC

Downstream 100 bases:

>100_bases
TCGGCACGGGATCAATCGTTATGGGCGGCGGTGAGAAGCTCTCCGCCGCCTTTTCTTGGCATCTGTGCATTTGTGCCCTT
ATTGTCGCGCCATGAAGATA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSEEQNVTSKKITSKTRNRLVAAVASAAIAGAVGFSAISSGTVPVFAEPVKLDRPVQAPSFADVVDVVTPAVVSVRISGE
APETGTVATPFFDMPGFDNLPPNHPLRRFFDEFQRRDEQPRGPQQRRRTRPVAQGSGFFISGDGYIVTNNHVVEGGNQYT
VVLEDGTELQADLIGKDPRTDLAVLKVKADREFTYVTWANDDAARVGDWVVAVGNPFGLGGTVTAGIVSARGREIGAGNY
DDFLQIDAAVNQGNSGGPTFNLAGEVVGVNTAIFSPSGGNVGIAFAIPASLAKTVVEQLIEDGSVERGYMGVSIQEVTPQ
IAESLGLQDARGALINSANSGDPAARAGIQAGDVVIAVNGKTIATPRELARTVAAIQPGTEIDVTVWRNGKSQDFSVTLT
EMPDTDQVASAAPSAPSQDEGGQPASFGLTVAPADDGNGLVVTDVEPGSVAEENGIQPGDVIRAINSQPVTTAGDLKKAA
DAASSAGRGAVLLQVVRDDANRFVALPIG

Sequences:

>Translated_509_residues
MSEEQNVTSKKITSKTRNRLVAAVASAAIAGAVGFSAISSGTVPVFAEPVKLDRPVQAPSFADVVDVVTPAVVSVRISGE
APETGTVATPFFDMPGFDNLPPNHPLRRFFDEFQRRDEQPRGPQQRRRTRPVAQGSGFFISGDGYIVTNNHVVEGGNQYT
VVLEDGTELQADLIGKDPRTDLAVLKVKADREFTYVTWANDDAARVGDWVVAVGNPFGLGGTVTAGIVSARGREIGAGNY
DDFLQIDAAVNQGNSGGPTFNLAGEVVGVNTAIFSPSGGNVGIAFAIPASLAKTVVEQLIEDGSVERGYMGVSIQEVTPQ
IAESLGLQDARGALINSANSGDPAARAGIQAGDVVIAVNGKTIATPRELARTVAAIQPGTEIDVTVWRNGKSQDFSVTLT
EMPDTDQVASAAPSAPSQDEGGQPASFGLTVAPADDGNGLVVTDVEPGSVAEENGIQPGDVIRAINSQPVTTAGDLKKAA
DAASSAGRGAVLLQVVRDDANRFVALPIG
>Mature_508_residues
SEEQNVTSKKITSKTRNRLVAAVASAAIAGAVGFSAISSGTVPVFAEPVKLDRPVQAPSFADVVDVVTPAVVSVRISGEA
PETGTVATPFFDMPGFDNLPPNHPLRRFFDEFQRRDEQPRGPQQRRRTRPVAQGSGFFISGDGYIVTNNHVVEGGNQYTV
VLEDGTELQADLIGKDPRTDLAVLKVKADREFTYVTWANDDAARVGDWVVAVGNPFGLGGTVTAGIVSARGREIGAGNYD
DFLQIDAAVNQGNSGGPTFNLAGEVVGVNTAIFSPSGGNVGIAFAIPASLAKTVVEQLIEDGSVERGYMGVSIQEVTPQI
AESLGLQDARGALINSANSGDPAARAGIQAGDVVIAVNGKTIATPRELARTVAAIQPGTEIDVTVWRNGKSQDFSVTLTE
MPDTDQVASAAPSAPSQDEGGQPASFGLTVAPADDGNGLVVTDVEPGSVAEENGIQPGDVIRAINSQPVTTAGDLKKAAD
AASSAGRGAVLLQVVRDDANRFVALPIG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=261, Percent_Identity=35.2490421455939, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI22129776, Length=270, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4506141, Length=288, Percent_Identity=32.9861111111111, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7019477, Length=287, Percent_Identity=32.404181184669, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1786356, Length=469, Percent_Identity=36.4605543710021, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1789629, Length=498, Percent_Identity=34.7389558232932, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789630, Length=277, Percent_Identity=41.5162454873646, Blast_Score=198, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=32.9861111111111, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52754; Mature: 52623

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEQNVTSKKITSKTRNRLVAAVASAAIAGAVGFSAISSGTVPVFAEPVKLDRPVQAPS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCC
FADVVDVVTPAVVSVRISGEAPETGTVATPFFDMPGFDNLPPNHPLRRFFDEFQRRDEQP
HHHHHHHHCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
RGPQQRRRTRPVAQGSGFFISGDGYIVTNNHVVEGGNQYTVVLEDGTELQADLIGKDPRT
CCHHHHHHCCCCCCCCCEEEECCCEEEECCEEEECCCEEEEEEECCCEEEHHHCCCCCCC
DLAVLKVKADREFTYVTWANDDAARVGDWVVAVGNPFGLGGTVTAGIVSARGREIGAGNY
CEEEEEEECCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCC
DDFLQIDAAVNQGNSGGPTFNLAGEVVGVNTAIFSPSGGNVGIAFAIPASLAKTVVEQLI
CCCEEEEEHHCCCCCCCCEEEECCEEEEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHH
EDGSVERGYMGVSIQEVTPQIAESLGLQDARGALINSANSGDPAARAGIQAGDVVIAVNG
HCCCCCCCEEEEEHHHHCHHHHHHCCCCCCCHHHEECCCCCCHHHHCCCCCCCEEEEECC
KTIATPRELARTVAAIQPGTEIDVTVWRNGKSQDFSVTLTEMPDTDQVASAAPSAPSQDE
CEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHCCCCCCCCCC
GGQPASFGLTVAPADDGNGLVVTDVEPGSVAEENGIQPGDVIRAINSQPVTTAGDLKKAA
CCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHCCCCHHHHHHHCCCCCCCCHHHHHHHH
DAASSAGRGAVLLQVVRDDANRFVALPIG
HHHCCCCCCEEEEEEEECCCCCEEEEECC
>Mature Secondary Structure 
SEEQNVTSKKITSKTRNRLVAAVASAAIAGAVGFSAISSGTVPVFAEPVKLDRPVQAPS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCC
FADVVDVVTPAVVSVRISGEAPETGTVATPFFDMPGFDNLPPNHPLRRFFDEFQRRDEQP
HHHHHHHHCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
RGPQQRRRTRPVAQGSGFFISGDGYIVTNNHVVEGGNQYTVVLEDGTELQADLIGKDPRT
CCHHHHHHCCCCCCCCCEEEECCCEEEECCEEEECCCEEEEEEECCCEEEHHHCCCCCCC
DLAVLKVKADREFTYVTWANDDAARVGDWVVAVGNPFGLGGTVTAGIVSARGREIGAGNY
CEEEEEEECCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCC
DDFLQIDAAVNQGNSGGPTFNLAGEVVGVNTAIFSPSGGNVGIAFAIPASLAKTVVEQLI
CCCEEEEEHHCCCCCCCCEEEECCEEEEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHH
EDGSVERGYMGVSIQEVTPQIAESLGLQDARGALINSANSGDPAARAGIQAGDVVIAVNG
HCCCCCCCEEEEEHHHHCHHHHHHCCCCCCCHHHEECCCCCCHHHHCCCCCCCEEEEECC
KTIATPRELARTVAAIQPGTEIDVTVWRNGKSQDFSVTLTEMPDTDQVASAAPSAPSQDE
CEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHCCCCCCCCCC
GGQPASFGLTVAPADDGNGLVVTDVEPGSVAEENGIQPGDVIRAINSQPVTTAGDLKKAA
CCCCCCCCEEEEECCCCCCEEEEECCCCCCHHHCCCCHHHHHHHCCCCCCCCHHHHHHHH
DAASSAGRGAVLLQVVRDDANRFVALPIG
HHHCCCCCCEEEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]