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The map label for this gene is cusR [H]

Identifier: 110633256

GI number: 110633256

Start: 992983

End: 993657

Strand: Direct

Name: cusR [H]

Synonym: Meso_0902

Alternate gene names: 110633256

Gene position: 992983-993657 (Clockwise)

Preceding gene: 110633255

Following gene: 110633257

Centisome position: 22.5

GC content: 61.04

Gene sequence:

>675_bases
ATGAAGATATTGATCATCGAAGATGACCGCGAGGCGGCGAGCTTCCTCAAGAAAGCCTTTTCCGAAGCGGGGCATATCGC
GGATGTGGCGTCCGACGGAGAGGCCGGCTTTGCGCTTGCCGATGGGGGCAATTACGATGTGTTCGTGATCGATCGCATGC
TCCCGCGCCGCGACGGGCTCTCCGTGATTGCGGGATTGCGAGCGAACGGCAACACGACGCCGGCGCTTATCCTCTCTGCT
TTAGGGGAGGTGGACGACCGGGTGACCGGCCTTCGCGCGGGCGGCGATGATTATCTTACGAAACCTTACGCGTTCTCAGA
ATTGCTCGCCCGCGTGGAAGTGCTGAAACGTCGAGCGGGCACACGCGACGTGGAAACGCTTTATCGGGCCGGCGATCTGG
AACTGGACCGGCTGTCACACACGGTGCGCCGAGGCGGGCAGGAGATCACGCTGCAGCCGCGCGAGTTCAGGCTGCTGGAA
TATCTAATGCGCCATGCCGGCCAGGTGGTCACGCGCACCATGCTTCTGGAGAATGTCTGGGACTATCACTTCGATCCCCA
GACCAATGTGATCGATGTGCATGTCTCGCGCCTCAGAGGCAAGATCGAGAGGGGCTTCGACAAGCCCATTCTGCACACGG
TGCGCGGGGCGGGTTATATGATCCGGGCGGACTGA

Upstream 100 bases:

>100_bases
ATTGGCTGATCGGCACGGGATCAATCGTTATGGGCGGCGGTGAGAAGCTCTCCGCCGCCTTTTCTTGGCATCTGTGCATT
TGTGCCCTTATTGTCGCGCC

Downstream 100 bases:

>100_bases
CCGATGGCCACGCTGTCGGCCGTCATGAAGACAACCGCTGCACGGCTTTCGGCACTTTATCTTGTGCTGTTCGCCGCTTG
CGCGGTGATGCTCGTCATCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKILIIEDDREAASFLKKAFSEAGHIADVASDGEAGFALADGGNYDVFVIDRMLPRRDGLSVIAGLRANGNTTPALILSA
LGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLKRRAGTRDVETLYRAGDLELDRLSHTVRRGGQEITLQPREFRLLE
YLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIERGFDKPILHTVRGAGYMIRAD

Sequences:

>Translated_224_residues
MKILIIEDDREAASFLKKAFSEAGHIADVASDGEAGFALADGGNYDVFVIDRMLPRRDGLSVIAGLRANGNTTPALILSA
LGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLKRRAGTRDVETLYRAGDLELDRLSHTVRRGGQEITLQPREFRLLE
YLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIERGFDKPILHTVRGAGYMIRAD
>Mature_224_residues
MKILIIEDDREAASFLKKAFSEAGHIADVASDGEAGFALADGGNYDVFVIDRMLPRRDGLSVIAGLRANGNTTPALILSA
LGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLKRRAGTRDVETLYRAGDLELDRLSHTVRRGGQEITLQPREFRLLE
YLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRGKIERGFDKPILHTVRGAGYMIRAD

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=45.7013574660633, Blast_Score=215, Evalue=2e-57,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=173, Evalue=9e-45,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=37.5, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=37.10407239819, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.0909090909091, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.6363636363636, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=31.3636363636364, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.4035087719298, Blast_Score=113, Evalue=8e-27,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=31.304347826087, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=30.6666666666667, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=30.1801801801802, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=28.3842794759825, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=30.1724137931034, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=29.1304347826087, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=28.4615384615385, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25010; Mature: 25010

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIIEDDREAASFLKKAFSEAGHIADVASDGEAGFALADGGNYDVFVIDRMLPRRDGL
CEEEEEECCHHHHHHHHHHHHHCCCEEHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCC
SVIAGLRANGNTTPALILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLKRRAG
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
TRDVETLYRAGDLELDRLSHTVRRGGQEITLQPREFRLLEYLMRHAGQVVTRTMLLENVW
CHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPQTNVIDVHVSRLRGKIERGFDKPILHTVRGAGYMIRAD
HCCCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MKILIIEDDREAASFLKKAFSEAGHIADVASDGEAGFALADGGNYDVFVIDRMLPRRDGL
CEEEEEECCHHHHHHHHHHHHHCCCEEHHCCCCCCCEEEECCCCEEEEEEECCCCCCCCC
SVIAGLRANGNTTPALILSALGEVDDRVTGLRAGGDDYLTKPYAFSELLARVEVLKRRAG
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
TRDVETLYRAGDLELDRLSHTVRRGGQEITLQPREFRLLEYLMRHAGQVVTRTMLLENVW
CHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYHFDPQTNVIDVHVSRLRGKIERGFDKPILHTVRGAGYMIRAD
HCCCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]