Click here to switch to the map view.

The map label for this gene is mutA [H]

Identifier: 110633214

GI number: 110633214

Start: 950237

End: 951676

Strand: Reverse

Name: mutA [H]

Synonym: Meso_0857

Alternate gene names: 110633214

Gene position: 951676-950237 (Counterclockwise)

Preceding gene: 110633216

Following gene: 110633213

Centisome position: 21.57

GC content: 65.97

Gene sequence:

>1440_bases
ATGGATCGGTCGATCCTGAAGAATGCGGACTTCCCGGCGGTCGACCGCCGGCAGTGGCTGGAACTCGTCGCCAAGTCTTT
GGGCAAGGATACGGATTTCTCGTCGCTGATCCGCCATACGGACGATGAATTGCCGATCGAGCCGCTCTATGAGCGCGCCA
GCGGCGCTTCCGCGCTCACCCGCGTCGATCCCGTTTCCTCGTGGAAGCTGATCCAGCGCATGGACGATCCGGACCCGGCA
CGGGCCAACGCGCAGGCAAGGGAGGATCTGGAAAAGGGCGCGACGGGGCTTTCCATCATCTTCGCCGGTGCTCCTAACGC
CTTCCGCTATGGTCTGCCGGCCACGGCCGAGGCGCTGGAGACAGCCCTTGCCGGATTGCCGCTCGAAGACGTGCATCTGA
GGATCGACGTCCATCCGCAAAGCCGCGCATCCGTCGACTGGCTGGCTGCGGTGCTCAAGAAGCACAAGGCCGATCCGGCG
CGGCTCAGCCTCTCCTTCGGCATCGATCCCGCCTCGCTTTTTGCGGGAACGGGCCGGCTGCGCATGTCTATCGAGGCGCT
GGAAGCTTCCATGCCGCAGTCGCTCGCGGGTTATTTCGTCCTCTCGCTCTCCGGGGTCCTGCTCGAGGCCGATGGCCGCG
TTTTCCACAATGCCGGCGCCACGGAAGCGCAGGAACTCGGCATCATGCTCGCCTCGGCCGTCTCGCATCTGAGAATGTTC
GAGGAGGCCCGCCAGCCGCTCGTCTATGCCGCGCCGCATATCGGATTCGCGCTTAGCGTCGATCAGGACCAGTTCCTCTC
CACGGCCAAGATCAGGGCGTTGCGCAAGCTCTGGACGCGGATGCTGGAGGCCTGCGCAATCGACCCCGCGCCAGTGACGA
TCCATGCGGAAACCTCGTACCGCATGATGACAGCGCGCGATCCCGAGACCAATATCCTGCGCACCACCATCGCCGGCTTT
GCCGCGGCAACGGGCGGCGCCGACTCGATTTCCGTGCTGCCGCACACCATCACCCACGGACTGCCCGACGGCTTTGCGCG
CCGGCTCGCGCGCAACACACAGCTCATCCTGGCGGGCGAAAGCCGGTTGGACTTCGTGGCCGATCCCGCGGCCGGCTCCG
GCGCCATCGAGGCGCTGACAGACGGGCTTTGCGAAAAGGCATGGGAGGAGTTCCGCCAGATCGAGAAGGAAGGCGGCGTA
CTGCGCAGCCTCGCCGCCGGTCACATCCAGCGGCGCGTAGCCTCCGCTCACGCCAAGCGCCTCGCCGAATTCCGCCAGGG
CGCCCGCAATATCGTCGGCACCACACTTTATAAGGCCGCGCAGGAGCGCCCCTTCGCAACGCTTCCTGCCGCGCGACAGC
CGATCCCGACGGACGGGGCGGTGACCTGCATTCCGCTTGCCGCCTCCCGCATCGACGAAGGGCTTGGAGAGCCCACATGA

Upstream 100 bases:

>100_bases
TACAGGCTGCTCTTCAAGCCAAGGTTGATGCAGAGGTGCATTGCAGCAAGCCGCGGCTCATCCTAAACTCATCGGGTCAT
ATGACGCGAACGGAGGCACG

Downstream 100 bases:

>100_bases
TCCCCGACTTTTCCGCCATGGCCTGGTCACCGCCGGCCAAGACGGAAGAGAAATGGCCGGCGGACCGGTGGCAAACGCCC
GAGGGCATCGCCATCCGCCA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MDRSILKNADFPAVDRRQWLELVAKSLGKDTDFSSLIRHTDDELPIEPLYERASGASALTRVDPVSSWKLIQRMDDPDPA
RANAQAREDLEKGATGLSIIFAGAPNAFRYGLPATAEALETALAGLPLEDVHLRIDVHPQSRASVDWLAAVLKKHKADPA
RLSLSFGIDPASLFAGTGRLRMSIEALEASMPQSLAGYFVLSLSGVLLEADGRVFHNAGATEAQELGIMLASAVSHLRMF
EEARQPLVYAAPHIGFALSVDQDQFLSTAKIRALRKLWTRMLEACAIDPAPVTIHAETSYRMMTARDPETNILRTTIAGF
AAATGGADSISVLPHTITHGLPDGFARRLARNTQLILAGESRLDFVADPAAGSGAIEALTDGLCEKAWEEFRQIEKEGGV
LRSLAAGHIQRRVASAHAKRLAEFRQGARNIVGTTLYKAAQERPFATLPAARQPIPTDGAVTCIPLAASRIDEGLGEPT

Sequences:

>Translated_479_residues
MDRSILKNADFPAVDRRQWLELVAKSLGKDTDFSSLIRHTDDELPIEPLYERASGASALTRVDPVSSWKLIQRMDDPDPA
RANAQAREDLEKGATGLSIIFAGAPNAFRYGLPATAEALETALAGLPLEDVHLRIDVHPQSRASVDWLAAVLKKHKADPA
RLSLSFGIDPASLFAGTGRLRMSIEALEASMPQSLAGYFVLSLSGVLLEADGRVFHNAGATEAQELGIMLASAVSHLRMF
EEARQPLVYAAPHIGFALSVDQDQFLSTAKIRALRKLWTRMLEACAIDPAPVTIHAETSYRMMTARDPETNILRTTIAGF
AAATGGADSISVLPHTITHGLPDGFARRLARNTQLILAGESRLDFVADPAAGSGAIEALTDGLCEKAWEEFRQIEKEGGV
LRSLAAGHIQRRVASAHAKRLAEFRQGARNIVGTTLYKAAQERPFATLPAARQPIPTDGAVTCIPLAASRIDEGLGEPT
>Mature_479_residues
MDRSILKNADFPAVDRRQWLELVAKSLGKDTDFSSLIRHTDDELPIEPLYERASGASALTRVDPVSSWKLIQRMDDPDPA
RANAQAREDLEKGATGLSIIFAGAPNAFRYGLPATAEALETALAGLPLEDVHLRIDVHPQSRASVDWLAAVLKKHKADPA
RLSLSFGIDPASLFAGTGRLRMSIEALEASMPQSLAGYFVLSLSGVLLEADGRVFHNAGATEAQELGIMLASAVSHLRMF
EEARQPLVYAAPHIGFALSVDQDQFLSTAKIRALRKLWTRMLEACAIDPAPVTIHAETSYRMMTARDPETNILRTTIAGF
AAATGGADSISVLPHTITHGLPDGFARRLARNTQLILAGESRLDFVADPAAGSGAIEALTDGLCEKAWEEFRQIEKEGGV
LRSLAAGHIQRRVASAHAKRLAEFRQGARNIVGTTLYKAAQERPFATLPAARQPIPTDGAVTCIPLAASRIDEGLGEPT

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=465, Percent_Identity=24.5161290322581, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1789284, Length=470, Percent_Identity=27.2340425531915, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25144500, Length=481, Percent_Identity=25.5717255717256, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 51627; Mature: 51627

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSILKNADFPAVDRRQWLELVAKSLGKDTDFSSLIRHTDDELPIEPLYERASGASALT
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHCCCCHHHH
RVDPVSSWKLIQRMDDPDPARANAQAREDLEKGATGLSIIFAGAPNAFRYGLPATAEALE
HCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHCCCCCHHHHHHH
TALAGLPLEDVHLRIDVHPQSRASVDWLAAVLKKHKADPARLSLSFGIDPASLFAGTGRL
HHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCHH
RMSIEALEASMPQSLAGYFVLSLSGVLLEADGRVFHNAGATEAQELGIMLASAVSHLRMF
EEHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
EEARQPLVYAAPHIGFALSVDQDQFLSTAKIRALRKLWTRMLEACAIDPAPVTIHAETSY
HHHCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
RMMTARDPETNILRTTIAGFAAATGGADSISVLPHTITHGLPDGFARRLARNTQLILAGE
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECC
SRLDFVADPAAGSGAIEALTDGLCEKAWEEFRQIEKEGGVLRSLAAGHIQRRVASAHAKR
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LAEFRQGARNIVGTTLYKAAQERPFATLPAARQPIPTDGAVTCIPLAASRIDEGLGEPT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDRSILKNADFPAVDRRQWLELVAKSLGKDTDFSSLIRHTDDELPIEPLYERASGASALT
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHCCCCHHHH
RVDPVSSWKLIQRMDDPDPARANAQAREDLEKGATGLSIIFAGAPNAFRYGLPATAEALE
HCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCHHCCCCCHHHHHHH
TALAGLPLEDVHLRIDVHPQSRASVDWLAAVLKKHKADPARLSLSFGIDPASLFAGTGRL
HHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCHH
RMSIEALEASMPQSLAGYFVLSLSGVLLEADGRVFHNAGATEAQELGIMLASAVSHLRMF
EEHHHHHHHHCCHHHHHHHHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHH
EEARQPLVYAAPHIGFALSVDQDQFLSTAKIRALRKLWTRMLEACAIDPAPVTIHAETSY
HHHCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
RMMTARDPETNILRTTIAGFAAATGGADSISVLPHTITHGLPDGFARRLARNTQLILAGE
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECC
SRLDFVADPAAGSGAIEALTDGLCEKAWEEFRQIEKEGGVLRSLAAGHIQRRVASAHAKR
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LAEFRQGARNIVGTTLYKAAQERPFATLPAARQPIPTDGAVTCIPLAASRIDEGLGEPT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]