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The map label for this gene is vllY [H]

Identifier: 110633139

GI number: 110633139

Start: 860292

End: 862184

Strand: Reverse

Name: vllY [H]

Synonym: Meso_0782

Alternate gene names: 110633139

Gene position: 862184-860292 (Counterclockwise)

Preceding gene: 110633140

Following gene: 110633136

Centisome position: 19.54

GC content: 61.75

Gene sequence:

>1893_bases
ATGAGAACTTCGATTGCGACTGTTTCCATCAGCGGCGAGTTCGAGGAGAAGCTTGCTGCCATTGCCCGCGCCGGCTTCGA
CGGCATCGAAATCTTCGAGAACGATCTGCTGGCTTTCGACAGGACGCCGGACGAGGTGGGTCGCATGGTGCGGGACCGTG
GGCTGGAGGTAAACCTTTTTCAGCCTTTCCGCGACTTCGAAGGCATGCCGGAGCCTTTCCGCAGCCGCAATTTCGACCGG
GCCGAGCGCAAGTTCGACCTGATGTGCGATCTCGGCACCGATCTGATGCTGGTCTGCTCGAACGTCTCACCTGTCTCGCT
TGGCGGCATTGACCGTGCCGCCGCCGACCTGCGCGAGCTGGGCGAACGCGCCGCGCGCCGCGGCCTGCGGGTCGGCTACG
AGGCGCTTGCCTGGGGCCGCCACATCAACGACCATCGCGACGCTTGGGAGATCGTGCGCCGCGCCGACCACCCGAATGTC
GGCATCATCCTCGACAGTTTCCACACGCTGTCGCGCAAGATCGACGTCAATTCCATCCGCGCCATTCCCGGCGACAAGAT
CTTCATCGTCCAACTGGCCGACGCACCGCTGATCGACATGGACCTGCTCTATTGGAGCCGGCACTTCCGCAACATGCCGG
GCGAAGGCGATCTGCCGGTGACCGATTTCATGCGCGCCGTCGCCGCCACCGGCTATGACGGCTATCTGTCGCTCGAAATC
TTCAACGACCAGTTCCGCGGCGGTTCGCCGACTGCGATCTCTGTCGATGGCCACCGCTCGCTCGTCTATCTGATGGATCA
GGTGGGGCGCAGCGATCCGGATATTGCTATCGCCGTTCCGGACATGCCGCCGCGCGCCGAGGTCACGGCCATCTCTTTCG
TCGAATTCGCGGCGGCGAAGGACGACCTGCCCCAACTGGAGGCCCTGCTCGCTTCACTCGGTTTCGCGCCGACCGGCCAC
CACCGGAGGAAGAGTGTCACGCTCTATCGCCAAGGTGACATCAACCTTGTGATCAATACTGAGGAAAGCGGCTTTCCTAG
CTCTTCCTACATGGTCCATGGCGCAAATGCCTATGCAATCGGGTTGAAGGTTGCCGACGCCCGCGCCGCCCATGACCGGG
CGATGGCGCTCGGCGCCGAACCGTTCGAGCAGTCGAACGGCCCCGGCGAGGTCACGATTCCTGCAATTCGCGGGCTTGGC
GGCGGCGTCATCTATTTCCTGGACGACGGAGAAGAACTCAAAGACATCTGGGAGAAAGAATTCGAATTCCTGCCGGGTGC
AACAGCCAGCGCAGCAACCGGGCTGACGCGCATCGATCACGTCGCGCAATCGGTGAAATCCGAGGAGCTGCTGACCTGGC
TGCTCTTCTACACGTCGATCCTCGATGCTCATAAGACGCCGATGGTCGACATCATCGATCCGGCTGGCGTTGTGCGAAGC
CAAGTCGTGGAAAACGACACGGGCACGCTGCGCATAACGCTGAACGGCGCTGAAAACCGCAAGACGCTCGCCGGCCATTT
CATCGCCGAGACCTTCGGTTCGAGCACTCAGCACCTTGCCTTCGAAACCAAGGACATCTTCGCCACCGCCGATGCACTGA
AGGAGCACGGCTTCGTTCCGCTGACCATCTCTCCGAACTATTACGGTGACGTCGAGGCCCGCTTCGGTCTCGATCCCGAG
CTCACCGAGGCGATCAAGCTGCGCAATATCCTTTATGACCGTGACGAGCACGGCGAATATTTCCAGCTCTATTCGCCAAC
CTATGGCGAGGGCTTCTTCATCGAAATTGTCGAACGGCGCGGCGGATATCGAGGCTATGGCGCCGCCAATGCCATCTTCC
GCATCGCGGCCCTGCGCAAGCACTTGCGCCCCGCTGGCATGCCGCGCCGGTAA

Upstream 100 bases:

>100_bases
CCCGAAGCCGGAGCTGTCGACGCCCTTGTCCGATCGCGCCAGCGGATCGCCGATCTGATCGGCGCACATGCCCGATGATC
ACACGCAGGAGGTCCATGCC

Downstream 100 bases:

>100_bases
GTCCTGTTCGCACGCCGCGACAGGCCGAGAGATTTCGCGATAAGCAAATCCGCCTATTCGCGAAACATCAAGACCGGGAT
TTTGCACCGGCGGACCATGG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MRTSIATVSISGEFEEKLAAIARAGFDGIEIFENDLLAFDRTPDEVGRMVRDRGLEVNLFQPFRDFEGMPEPFRSRNFDR
AERKFDLMCDLGTDLMLVCSNVSPVSLGGIDRAAADLRELGERAARRGLRVGYEALAWGRHINDHRDAWEIVRRADHPNV
GIILDSFHTLSRKIDVNSIRAIPGDKIFIVQLADAPLIDMDLLYWSRHFRNMPGEGDLPVTDFMRAVAATGYDGYLSLEI
FNDQFRGGSPTAISVDGHRSLVYLMDQVGRSDPDIAIAVPDMPPRAEVTAISFVEFAAAKDDLPQLEALLASLGFAPTGH
HRRKSVTLYRQGDINLVINTEESGFPSSSYMVHGANAYAIGLKVADARAAHDRAMALGAEPFEQSNGPGEVTIPAIRGLG
GGVIYFLDDGEELKDIWEKEFEFLPGATASAATGLTRIDHVAQSVKSEELLTWLLFYTSILDAHKTPMVDIIDPAGVVRS
QVVENDTGTLRITLNGAENRKTLAGHFIAETFGSSTQHLAFETKDIFATADALKEHGFVPLTISPNYYGDVEARFGLDPE
LTEAIKLRNILYDRDEHGEYFQLYSPTYGEGFFIEIVERRGGYRGYGAANAIFRIAALRKHLRPAGMPRR

Sequences:

>Translated_630_residues
MRTSIATVSISGEFEEKLAAIARAGFDGIEIFENDLLAFDRTPDEVGRMVRDRGLEVNLFQPFRDFEGMPEPFRSRNFDR
AERKFDLMCDLGTDLMLVCSNVSPVSLGGIDRAAADLRELGERAARRGLRVGYEALAWGRHINDHRDAWEIVRRADHPNV
GIILDSFHTLSRKIDVNSIRAIPGDKIFIVQLADAPLIDMDLLYWSRHFRNMPGEGDLPVTDFMRAVAATGYDGYLSLEI
FNDQFRGGSPTAISVDGHRSLVYLMDQVGRSDPDIAIAVPDMPPRAEVTAISFVEFAAAKDDLPQLEALLASLGFAPTGH
HRRKSVTLYRQGDINLVINTEESGFPSSSYMVHGANAYAIGLKVADARAAHDRAMALGAEPFEQSNGPGEVTIPAIRGLG
GGVIYFLDDGEELKDIWEKEFEFLPGATASAATGLTRIDHVAQSVKSEELLTWLLFYTSILDAHKTPMVDIIDPAGVVRS
QVVENDTGTLRITLNGAENRKTLAGHFIAETFGSSTQHLAFETKDIFATADALKEHGFVPLTISPNYYGDVEARFGLDPE
LTEAIKLRNILYDRDEHGEYFQLYSPTYGEGFFIEIVERRGGYRGYGAANAIFRIAALRKHLRPAGMPRR
>Mature_630_residues
MRTSIATVSISGEFEEKLAAIARAGFDGIEIFENDLLAFDRTPDEVGRMVRDRGLEVNLFQPFRDFEGMPEPFRSRNFDR
AERKFDLMCDLGTDLMLVCSNVSPVSLGGIDRAAADLRELGERAARRGLRVGYEALAWGRHINDHRDAWEIVRRADHPNV
GIILDSFHTLSRKIDVNSIRAIPGDKIFIVQLADAPLIDMDLLYWSRHFRNMPGEGDLPVTDFMRAVAATGYDGYLSLEI
FNDQFRGGSPTAISVDGHRSLVYLMDQVGRSDPDIAIAVPDMPPRAEVTAISFVEFAAAKDDLPQLEALLASLGFAPTGH
HRRKSVTLYRQGDINLVINTEESGFPSSSYMVHGANAYAIGLKVADARAAHDRAMALGAEPFEQSNGPGEVTIPAIRGLG
GGVIYFLDDGEELKDIWEKEFEFLPGATASAATGLTRIDHVAQSVKSEELLTWLLFYTSILDAHKTPMVDIIDPAGVVRS
QVVENDTGTLRITLNGAENRKTLAGHFIAETFGSSTQHLAFETKDIFATADALKEHGFVPLTISPNYYGDVEARFGLDPE
LTEAIKLRNILYDRDEHGEYFQLYSPTYGEGFFIEIVERRGGYRGYGAANAIFRIAALRKHLRPAGMPRR

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=350, Percent_Identity=22.2857142857143, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI285002264, Length=347, Percent_Identity=22.478386167147, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555220, Length=354, Percent_Identity=24.0112994350282, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24667510, Length=337, Percent_Identity=27.5964391691395, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356105, Length=287, Percent_Identity=27.5261324041812, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 69748; Mature: 69748

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTSIATVSISGEFEEKLAAIARAGFDGIEIFENDLLAFDRTPDEVGRMVRDRGLEVNLF
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHCCEEEECCCHHHHHHHHHHCCCEEEEE
QPFRDFEGMPEPFRSRNFDRAERKFDLMCDLGTDLMLVCSNVSPVSLGGIDRAAADLREL
CCHHHCCCCCCHHHCCCCCHHHHHEEEEEECCCCEEEEECCCCCEECCCCHHHHHHHHHH
GERAARRGLRVGYEALAWGRHINDHRDAWEIVRRADHPNVGIILDSFHTLSRKIDVNSIR
HHHHHHCCHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHCCCCCCEE
AIPGDKIFIVQLADAPLIDMDLLYWSRHFRNMPGEGDLPVTDFMRAVAATGYDGYLSLEI
ECCCCEEEEEEECCCCEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
FNDQFRGGSPTAISVDGHRSLVYLMDQVGRSDPDIAIAVPDMPPRAEVTAISFVEFAAAK
ECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEEHHHHHHHHHCC
DDLPQLEALLASLGFAPTGHHRRKSVTLYRQGDINLVINTEESGFPSSSYMVHGANAYAI
CCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCEEEECCCEEEE
GLKVADARAAHDRAMALGAEPFEQSNGPGEVTIPAIRGLGGGVIYFLDDGEELKDIWEKE
EEEEECCHHHHHHHHHCCCCCHHCCCCCCCEEEHEECCCCCCEEEEECCCHHHHHHHHHH
FEFLPGATASAATGLTRIDHVAQSVKSEELLTWLLFYTSILDAHKTPMVDIIDPAGVVRS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHH
QVVENDTGTLRITLNGAENRKTLAGHFIAETFGSSTQHLAFETKDIFATADALKEHGFVP
HHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCEE
LTISPNYYGDVEARFGLDPELTEAIKLRNILYDRDEHGEYFQLYSPTYGEGFFIEIVERR
EEECCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECC
GGYRGYGAANAIFRIAALRKHLRPAGMPRR
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRTSIATVSISGEFEEKLAAIARAGFDGIEIFENDLLAFDRTPDEVGRMVRDRGLEVNLF
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHCCEEEECCCHHHHHHHHHHCCCEEEEE
QPFRDFEGMPEPFRSRNFDRAERKFDLMCDLGTDLMLVCSNVSPVSLGGIDRAAADLREL
CCHHHCCCCCCHHHCCCCCHHHHHEEEEEECCCCEEEEECCCCCEECCCCHHHHHHHHHH
GERAARRGLRVGYEALAWGRHINDHRDAWEIVRRADHPNVGIILDSFHTLSRKIDVNSIR
HHHHHHCCHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHCCCCCCEE
AIPGDKIFIVQLADAPLIDMDLLYWSRHFRNMPGEGDLPVTDFMRAVAATGYDGYLSLEI
ECCCCEEEEEEECCCCEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEE
FNDQFRGGSPTAISVDGHRSLVYLMDQVGRSDPDIAIAVPDMPPRAEVTAISFVEFAAAK
ECCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCEEHHHHHHHHHCC
DDLPQLEALLASLGFAPTGHHRRKSVTLYRQGDINLVINTEESGFPSSSYMVHGANAYAI
CCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCEEEECCCEEEE
GLKVADARAAHDRAMALGAEPFEQSNGPGEVTIPAIRGLGGGVIYFLDDGEELKDIWEKE
EEEEECCHHHHHHHHHCCCCCHHCCCCCCCEEEHEECCCCCCEEEEECCCHHHHHHHHHH
FEFLPGATASAATGLTRIDHVAQSVKSEELLTWLLFYTSILDAHKTPMVDIIDPAGVVRS
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHH
QVVENDTGTLRITLNGAENRKTLAGHFIAETFGSSTQHLAFETKDIFATADALKEHGFVP
HHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCEE
LTISPNYYGDVEARFGLDPELTEAIKLRNILYDRDEHGEYFQLYSPTYGEGFFIEIVERR
EEECCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEEECC
GGYRGYGAANAIFRIAALRKHLRPAGMPRR
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA