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The map label for this gene is yfhQ [H]

Identifier: 110633122

GI number: 110633122

Start: 839949

End: 841073

Strand: Reverse

Name: yfhQ [H]

Synonym: Meso_0765

Alternate gene names: 110633122

Gene position: 841073-839949 (Counterclockwise)

Preceding gene: 110633128

Following gene: 110633121

Centisome position: 19.06

GC content: 67.11

Gene sequence:

>1125_bases
ATGACACAGCGAATGACGGCGGAACGAAGGCCGGCAGCGGATGAGACCTCATTCGCCGAAGACCTTCTCCTCTGGTATGA
CCGGCACCATCGCCGCCTTCCCTGGCGCATGCCGCCCGCAATGATCCGGGGTGGGGAGCGGCCCGATCCCTACAGCGTCT
GGCTGTCGGAGATCATGCTGCAGCAGACGACCGTGAGCGCGGTGAAACCCTATTTCGAAAAGTTCCTTGCGCGCTGGCCG
ACCGTCGAGGCGCTGGCAGCCGCTGAAACCGACGACGTCATGAAGGCCTGGGCGGGCCTCGGCTATTATTCGCGGGCACG
CAACCTGAAGAAATGCGCCGAGGCGGTGGCGGAGCGGCACGGCGGCCGGTTTCCCGCCACCGAAGCCGGCCTGAAGGACT
TGCCCGGCATCGGCGACTATACGGCGGCGGCCATCGCGGCGATCGCCTTCAACCGCCCGGCCGCGGTGGTAGACGGCAAT
GTGGAGCGCGTGGTCACCCGGCTCAAGGCAATCGAGACGCCGCTTCCCGCCGCCAAGCCGGAGATCCGCAACGTGGTGGA
AGCGCTGCTGCCGCAAGCGCGGCCCGGCGATTTCGCGCAGGCGATGATGGATCTGGGCGCCACGATCTGCACGCCGCGCC
GGCCCTCCTGCATCCTTTGCCCGGTCGGCGAGCACTGTATGGCTCGCGCCCTCAAGGCGCAGGAGCGGTTCCCGATCAAG
GCCGCCAAGGCGGACAAGCCGCTGCGGCAAGGCGCGGCATTCGTCGCGGTGCGCGCGGACGGTTCGGTTCTCCTGCGGCA
GCGGCCGGAAAAAGGCCTGCTCGGCGGCATGACCGAGGTGCCGACCAGCGCCTGGACCGCCCGGCAGGATGGAGAGAGCA
CCAGGGCAGCGGCCCCCTTCCCCGGCAGTTGGACGAGCTGCGGCGCGATCACGCATGTCTTCACCCATTTTGCCCTCAAT
CTTTCCGTATTCCGGGCAGAAGTCCCGGATTTTGAAGCGCCCTCGGGCCATTGGTGGTCGGCACCGCGCGAATTGCGCGG
GGAAGCGCTGCCGACCGTCATGAAAAAAGCGATCGAGGCCGCTATACCCGGCGCGACAAAGACAAGGAGACAAGACGCCC
GATGA

Upstream 100 bases:

>100_bases
CTGGCGAGATCGCTCACCGGTATGGGATTGCCTGGGCGCATCTTCCCTGTCATGTGCTTTACCTCGGTGGAAACGCAAAC
CTAACGCATTGCGCCCGAAT

Downstream 100 bases:

>100_bases
GCGAAATCCGCCACATCGTCTTCGATATCGGCAAGGTTCTGATCCATTACGACCCGGAGATCCCTTATTCGCGGCTCATT
CCCGATGCGCAAGAGCGACG

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTQRMTAERRPAADETSFAEDLLLWYDRHHRRLPWRMPPAMIRGGERPDPYSVWLSEIMLQQTTVSAVKPYFEKFLARWP
TVEALAAAETDDVMKAWAGLGYYSRARNLKKCAEAVAERHGGRFPATEAGLKDLPGIGDYTAAAIAAIAFNRPAAVVDGN
VERVVTRLKAIETPLPAAKPEIRNVVEALLPQARPGDFAQAMMDLGATICTPRRPSCILCPVGEHCMARALKAQERFPIK
AAKADKPLRQGAAFVAVRADGSVLLRQRPEKGLLGGMTEVPTSAWTARQDGESTRAAAPFPGSWTSCGAITHVFTHFALN
LSVFRAEVPDFEAPSGHWWSAPRELRGEALPTVMKKAIEAAIPGATKTRRQDAR

Sequences:

>Translated_374_residues
MTQRMTAERRPAADETSFAEDLLLWYDRHHRRLPWRMPPAMIRGGERPDPYSVWLSEIMLQQTTVSAVKPYFEKFLARWP
TVEALAAAETDDVMKAWAGLGYYSRARNLKKCAEAVAERHGGRFPATEAGLKDLPGIGDYTAAAIAAIAFNRPAAVVDGN
VERVVTRLKAIETPLPAAKPEIRNVVEALLPQARPGDFAQAMMDLGATICTPRRPSCILCPVGEHCMARALKAQERFPIK
AAKADKPLRQGAAFVAVRADGSVLLRQRPEKGLLGGMTEVPTSAWTARQDGESTRAAAPFPGSWTSCGAITHVFTHFALN
LSVFRAEVPDFEAPSGHWWSAPRELRGEALPTVMKKAIEAAIPGATKTRRQDAR
>Mature_373_residues
TQRMTAERRPAADETSFAEDLLLWYDRHHRRLPWRMPPAMIRGGERPDPYSVWLSEIMLQQTTVSAVKPYFEKFLARWPT
VEALAAAETDDVMKAWAGLGYYSRARNLKKCAEAVAERHGGRFPATEAGLKDLPGIGDYTAAAIAAIAFNRPAAVVDGNV
ERVVTRLKAIETPLPAAKPEIRNVVEALLPQARPGDFAQAMMDLGATICTPRRPSCILCPVGEHCMARALKAQERFPIKA
AKADKPLRQGAAFVAVRADGSVLLRQRPEKGLLGGMTEVPTSAWTARQDGESTRAAAPFPGSWTSCGAITHVFTHFALNL
SVFRAEVPDFEAPSGHWWSAPRELRGEALPTVMKKAIEAAIPGATKTRRQDAR

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=414, Percent_Identity=35.7487922705314, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI115298652, Length=414, Percent_Identity=35.7487922705314, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI115298650, Length=414, Percent_Identity=35.7487922705314, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI115298648, Length=414, Percent_Identity=35.7487922705314, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI190358497, Length=414, Percent_Identity=35.7487922705314, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI6912520, Length=414, Percent_Identity=35.7487922705314, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1789331, Length=313, Percent_Identity=42.1725239616613, Blast_Score=224, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41031; Mature: 40899

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRMTAERRPAADETSFAEDLLLWYDRHHRRLPWRMPPAMIRGGERPDPYSVWLSEIML
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHH
QQTTVSAVKPYFEKFLARWPTVEALAAAETDDVMKAWAGLGYYSRARNLKKCAEAVAERH
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GGRFPATEAGLKDLPGIGDYTAAAIAAIAFNRPAAVVDGNVERVVTRLKAIETPLPAAKP
CCCCCCHHCCHHHCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCH
EIRNVVEALLPQARPGDFAQAMMDLGATICTPRRPSCILCPVGEHCMARALKAQERFPIK
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCC
AAKADKPLRQGAAFVAVRADGSVLLRQRPEKGLLGGMTEVPTSAWTARQDGESTRAAAPF
HHHCCCHHHCCCEEEEEECCCCCHHHCCCCCCHHCCCHHCCCHHHHCCCCCCCCCCCCCC
PGSWTSCGAITHVFTHFALNLSVFRAEVPDFEAPSGHWWSAPRELRGEALPTVMKKAIEA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHH
AIPGATKTRRQDAR
HCCCCCHHHHCCCC
>Mature Secondary Structure 
TQRMTAERRPAADETSFAEDLLLWYDRHHRRLPWRMPPAMIRGGERPDPYSVWLSEIML
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHH
QQTTVSAVKPYFEKFLARWPTVEALAAAETDDVMKAWAGLGYYSRARNLKKCAEAVAERH
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GGRFPATEAGLKDLPGIGDYTAAAIAAIAFNRPAAVVDGNVERVVTRLKAIETPLPAAKP
CCCCCCHHCCHHHCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHCCCCCCCH
EIRNVVEALLPQARPGDFAQAMMDLGATICTPRRPSCILCPVGEHCMARALKAQERFPIK
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCC
AAKADKPLRQGAAFVAVRADGSVLLRQRPEKGLLGGMTEVPTSAWTARQDGESTRAAAPF
HHHCCCHHHCCCEEEEEECCCCCHHHCCCCCCHHCCCHHCCCHHHHCCCCCCCCCCCCCC
PGSWTSCGAITHVFTHFALNLSVFRAEVPDFEAPSGHWWSAPRELRGEALPTVMKKAIEA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHH
AIPGATKTRRQDAR
HCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]