Click here to switch to the map view.

The map label for this gene is cya [H]

Identifier: 110632973

GI number: 110632973

Start: 689225

End: 691462

Strand: Reverse

Name: cya [H]

Synonym: Meso_0616

Alternate gene names: 110632973

Gene position: 691462-689225 (Counterclockwise)

Preceding gene: 110632974

Following gene: 110632972

Centisome position: 15.67

GC content: 59.61

Gene sequence:

>2238_bases
ATGCCCGCAACCGCCACCTATAATCTGACCGGCAACGCCTATATCGACGGCTTGCTGAGTGGAATCAAATGGGCGCCCAC
CAATCTCACCTACAGCTTTCCCACCAGCGCATCCTATTACGGGTCGGGTTACGGAAGCGGGGAGCCCGGCAGCAATTTCG
GCGCGCTGAACTCGGCACAGCAGGCGGCTGGCCGCGCGGCATTCGATATCTTCTCTTCGGTCGCGAACATCACCTTCAGC
GAAATTGCCGAAACGTCGAACCAGCATGCCGATCTGCGGCTGGCCGCCAGTGACATGGTCGGCACCGCGTGGGCCTATTA
TCCTTCCACCAGGTCTGAGGGCGGGGATGTCTGGTTCAACAAGTCTAACGGCTACTACACGAGCCCGCAGGCAGGGAACT
ACGCCTTCACGACATTCCTGCACGAGATCGGTCATGCGCTGGGTCTTGAGCATGCCCATGAGGGTCACGTGATGCCCGCT
GGCCGTGACTCCATGGAATATACGGTCATGAGCTATCGTTCCTATGTCGGCGCCTCGACGACATCAGGATATGTCAATGA
AAAGTGGGGCTTTGCCCAGTCACTCATGATGTATGACATAGCCGCCCTGCAGCACATGTATGGCGCGAACTACAGCACCA
ATTCCGGCGCCACCACCTATTCCTGGAGTCCAACCACCGGGCAGATGTTCATCAACGGCACCGGTCAGGACATGCCGGGT
GCGAACCGCATCTTCCTCACCGTGTGGGACGGAGGGGGTGCCGACACCTACAATTTCTCGGCATACAGCACCTCTCTCAA
GGTGGATCTGAGACCGGGCGCGTGGACCACCACCTCATCGGACCAGCTTGCCCGGCTGCATTACGACGGCTCGAAGCTTG
CCGCCGGCAACATCGCCAACGCTCTTCTCCATGGAAACGATCCGCGGTCGCTGATCGAAAACGCGAAGGGCGGCTCAGCC
AGCGACAGGATCACCGGGAATACAGCGGTCAACAAGCTGTGTGGAAATGGCGGAAACGACACGCTGAACGGCATGGAAGG
GAACGATGTGCTGATCGGCGGAGCAGGCGCAGACAAACTCAACGGCGGGTCCGGCTTCGACTACGCCAGCTACACGGATG
CAACCGCCGGGGTAGTGGCTCGGCTCTACGCGCCAACGACTAATAAGGGCTATGCGGCCGGTGACACATATACCAGCATC
GAAGGCCTGATCGGCAGTGCGCACAGTGACCAGCTCTCCGGCGATGAGGCCGGCAACAAACTCCACGGAGGCGCGGGCAA
CGATGTGCTCTATGGCCTAGGGGGCAATGACGCGCTTTATGGCGTAGACGGCAATGACAAGCTTTTCGGCAGCGCAGGCG
CAGATAAGCTCGATGGCGGGGCAGGCTTCGATTACGCCAGCTACCAGGATGCAACCGCCGGGGTAGTGTCGCGGCTCGAC
GCGCCCAAAGCCAACAGCGGCCACGCGGCAGGTGACACCTATAGCAGCATCGAAGGCCTGATCGGCAGCAAGTACAGCGA
CAAGCTTTACGGCGATGCAGCCCGCAACAAGCTCTTTGGAGGGGCGGGCAATGATGTGCTCTATGGCCTGGGGGGCAACG
ACGCGCTTTATGGCATGGACGGCACTGACAAGCTTGTGGGCAGTGCAGGCGCAGATAAGCTCGATGGCGGGGCAGGCTTC
GATTATGCCAGCTACCAGGATGCAACGGCTGGCGTAGTGGCGCGGCTCGATCGGCCTTCGAGTAACACTGGCTATGCGGC
CGGTGACACATATACCGGCATCGAAGGCTTGATGGGCAGCAAGTACACAGACAAGCTTTACGGCGATGCGGCTGCTAACA
GGCTTTACGGGGAAGCGGGCAATGATGTGCTTTATGGCCTCGGCGGCAATGATGTGCTGATCGGCGGCGCAGGCGCGGAC
AGGCTGTACGGAGGCGCAGGCGCGGACAGATTCGTCATCGACAAAATCGGCAACTCGCTTCCGACCGCCCGTGACCGGAT
AGGCGACTTTACGCGAGGTGAGGACAAGATCGACTTAAGATCAATCGACGCGAACACTTCACTCGGCGGCGACCAGGCCT
TTTCCTTCATCGGGGGCAAGGCGTTCAGCGGCAAGGCGAGCGAACTTAACTTCGCTGGCAACGTTCTTTCCGGTGACGTG
AACGGCGATCGCATAGCAGATTTCCAGGTCGATATTCCGAACGTTTCCAGCCTTCTGGGAACTGATTTCTACCTCTAA

Upstream 100 bases:

>100_bases
ACCTTCTTCGGCTATATCGCCGCCCCTCTCATGAAAACACTCTCCCGGTCCGTCCGGGAGAGCTGAGCACCACTTGACCC
AAGCAGAGTAGAGAAAACAA

Downstream 100 bases:

>100_bases
GGATCAGGAGGCCTACATGAGTGAATGGATCGACTTCTCACGCTGGCCGGATTGTGCTTCGATGGAAAGGCCCGGGCTGG
TGTTCGAGGTACAAAATGCC

Product: peptidase, metallopeptidases

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MPATATYNLTGNAYIDGLLSGIKWAPTNLTYSFPTSASYYGSGYGSGEPGSNFGALNSAQQAAGRAAFDIFSSVANITFS
EIAETSNQHADLRLAASDMVGTAWAYYPSTRSEGGDVWFNKSNGYYTSPQAGNYAFTTFLHEIGHALGLEHAHEGHVMPA
GRDSMEYTVMSYRSYVGASTTSGYVNEKWGFAQSLMMYDIAALQHMYGANYSTNSGATTYSWSPTTGQMFINGTGQDMPG
ANRIFLTVWDGGGADTYNFSAYSTSLKVDLRPGAWTTTSSDQLARLHYDGSKLAAGNIANALLHGNDPRSLIENAKGGSA
SDRITGNTAVNKLCGNGGNDTLNGMEGNDVLIGGAGADKLNGGSGFDYASYTDATAGVVARLYAPTTNKGYAAGDTYTSI
EGLIGSAHSDQLSGDEAGNKLHGGAGNDVLYGLGGNDALYGVDGNDKLFGSAGADKLDGGAGFDYASYQDATAGVVSRLD
APKANSGHAAGDTYSSIEGLIGSKYSDKLYGDAARNKLFGGAGNDVLYGLGGNDALYGMDGTDKLVGSAGADKLDGGAGF
DYASYQDATAGVVARLDRPSSNTGYAAGDTYTGIEGLMGSKYTDKLYGDAAANRLYGEAGNDVLYGLGGNDVLIGGAGAD
RLYGGAGADRFVIDKIGNSLPTARDRIGDFTRGEDKIDLRSIDANTSLGGDQAFSFIGGKAFSGKASELNFAGNVLSGDV
NGDRIADFQVDIPNVSSLLGTDFYL

Sequences:

>Translated_745_residues
MPATATYNLTGNAYIDGLLSGIKWAPTNLTYSFPTSASYYGSGYGSGEPGSNFGALNSAQQAAGRAAFDIFSSVANITFS
EIAETSNQHADLRLAASDMVGTAWAYYPSTRSEGGDVWFNKSNGYYTSPQAGNYAFTTFLHEIGHALGLEHAHEGHVMPA
GRDSMEYTVMSYRSYVGASTTSGYVNEKWGFAQSLMMYDIAALQHMYGANYSTNSGATTYSWSPTTGQMFINGTGQDMPG
ANRIFLTVWDGGGADTYNFSAYSTSLKVDLRPGAWTTTSSDQLARLHYDGSKLAAGNIANALLHGNDPRSLIENAKGGSA
SDRITGNTAVNKLCGNGGNDTLNGMEGNDVLIGGAGADKLNGGSGFDYASYTDATAGVVARLYAPTTNKGYAAGDTYTSI
EGLIGSAHSDQLSGDEAGNKLHGGAGNDVLYGLGGNDALYGVDGNDKLFGSAGADKLDGGAGFDYASYQDATAGVVSRLD
APKANSGHAAGDTYSSIEGLIGSKYSDKLYGDAARNKLFGGAGNDVLYGLGGNDALYGMDGTDKLVGSAGADKLDGGAGF
DYASYQDATAGVVARLDRPSSNTGYAAGDTYTGIEGLMGSKYTDKLYGDAAANRLYGEAGNDVLYGLGGNDVLIGGAGAD
RLYGGAGADRFVIDKIGNSLPTARDRIGDFTRGEDKIDLRSIDANTSLGGDQAFSFIGGKAFSGKASELNFAGNVLSGDV
NGDRIADFQVDIPNVSSLLGTDFYL
>Mature_744_residues
PATATYNLTGNAYIDGLLSGIKWAPTNLTYSFPTSASYYGSGYGSGEPGSNFGALNSAQQAAGRAAFDIFSSVANITFSE
IAETSNQHADLRLAASDMVGTAWAYYPSTRSEGGDVWFNKSNGYYTSPQAGNYAFTTFLHEIGHALGLEHAHEGHVMPAG
RDSMEYTVMSYRSYVGASTTSGYVNEKWGFAQSLMMYDIAALQHMYGANYSTNSGATTYSWSPTTGQMFINGTGQDMPGA
NRIFLTVWDGGGADTYNFSAYSTSLKVDLRPGAWTTTSSDQLARLHYDGSKLAAGNIANALLHGNDPRSLIENAKGGSAS
DRITGNTAVNKLCGNGGNDTLNGMEGNDVLIGGAGADKLNGGSGFDYASYTDATAGVVARLYAPTTNKGYAAGDTYTSIE
GLIGSAHSDQLSGDEAGNKLHGGAGNDVLYGLGGNDALYGVDGNDKLFGSAGADKLDGGAGFDYASYQDATAGVVSRLDA
PKANSGHAAGDTYSSIEGLIGSKYSDKLYGDAARNKLFGGAGNDVLYGLGGNDALYGMDGTDKLVGSAGADKLDGGAGFD
YASYQDATAGVVARLDRPSSNTGYAAGDTYTGIEGLMGSKYTDKLYGDAAANRLYGEAGNDVLYGLGGNDVLIGGAGADR
LYGGAGADRFVIDKIGNSLPTARDRIGDFTRGEDKIDLRSIDANTSLGGDQAFSFIGGKAFSGKASELNFAGNVLSGDVN
GDRIADFQVDIPNVSSLLGTDFYL

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 77107; Mature: 76976

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00142 ZINC_PROTEASE ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPATATYNLTGNAYIDGLLSGIKWAPTNLTYSFPTSASYYGSGYGSGEPGSNFGALNSAQ
CCCCEEEECCCCHHHHHHHHCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
QAAGRAAFDIFSSVANITFSEIAETSNQHADLRLAASDMVGTAWAYYPSTRSEGGDVWFN
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEE
KSNGYYTSPQAGNYAFTTFLHEIGHALGLEHAHEGHVMPAGRDSMEYTVMSYRSYVGAST
CCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
TSGYVNEKWGFAQSLMMYDIAALQHMYGANYSTNSGATTYSWSPTTGQMFINGTGQDMPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCC
ANRIFLTVWDGGGADTYNFSAYSTSLKVDLRPGAWTTTSSDQLARLHYDGSKLAAGNIAN
CCEEEEEEECCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEECCCEEECCHHHH
ALLHGNDPRSLIENAKGGSASDRITGNTAVNKLCGNGGNDTLNGMEGNDVLIGGAGADKL
HEECCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCC
NGGSGFDYASYTDATAGVVARLYAPTTNKGYAAGDTYTSIEGLIGSAHSDQLSGDEAGNK
CCCCCCCCCCCCCHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
LHGGAGNDVLYGLGGNDALYGVDGNDKLFGSAGADKLDGGAGFDYASYQDATAGVVSRLD
CCCCCCCCEEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
APKANSGHAAGDTYSSIEGLIGSKYSDKLYGDAARNKLFGGAGNDVLYGLGGNDALYGMD
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCHHHHHCCCCCCCCCEEEEECCCCEEECCC
GTDKLVGSAGADKLDGGAGFDYASYQDATAGVVARLDRPSSNTGYAAGDTYTGIEGLMGS
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCC
KYTDKLYGDAAANRLYGEAGNDVLYGLGGNDVLIGGAGADRLYGGAGADRFVIDKIGNSL
CHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHCCCC
PTARDRIGDFTRGEDKIDLRSIDANTSLGGDQAFSFIGGKAFSGKASELNFAGNVLSGDV
CCHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCEEECCC
NGDRIADFQVDIPNVSSLLGTDFYL
CCCEEEEEEECCCCHHHHHCCCCCC
>Mature Secondary Structure 
PATATYNLTGNAYIDGLLSGIKWAPTNLTYSFPTSASYYGSGYGSGEPGSNFGALNSAQ
CCCEEEECCCCHHHHHHHHCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
QAAGRAAFDIFSSVANITFSEIAETSNQHADLRLAASDMVGTAWAYYPSTRSEGGDVWFN
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEE
KSNGYYTSPQAGNYAFTTFLHEIGHALGLEHAHEGHVMPAGRDSMEYTVMSYRSYVGAST
CCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
TSGYVNEKWGFAQSLMMYDIAALQHMYGANYSTNSGATTYSWSPTTGQMFINGTGQDMPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCC
ANRIFLTVWDGGGADTYNFSAYSTSLKVDLRPGAWTTTSSDQLARLHYDGSKLAAGNIAN
CCEEEEEEECCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCEEEEEECCCEEECCHHHH
ALLHGNDPRSLIENAKGGSASDRITGNTAVNKLCGNGGNDTLNGMEGNDVLIGGAGADKL
HEECCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCC
NGGSGFDYASYTDATAGVVARLYAPTTNKGYAAGDTYTSIEGLIGSAHSDQLSGDEAGNK
CCCCCCCCCCCCCHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
LHGGAGNDVLYGLGGNDALYGVDGNDKLFGSAGADKLDGGAGFDYASYQDATAGVVSRLD
CCCCCCCCEEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
APKANSGHAAGDTYSSIEGLIGSKYSDKLYGDAARNKLFGGAGNDVLYGLGGNDALYGMD
CCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCHHHHHCCCCCCCCCEEEEECCCCEEECCC
GTDKLVGSAGADKLDGGAGFDYASYQDATAGVVARLDRPSSNTGYAAGDTYTGIEGLMGS
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCC
KYTDKLYGDAAANRLYGEAGNDVLYGLGGNDVLIGGAGADRLYGGAGADRFVIDKIGNSL
CHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHCCCC
PTARDRIGDFTRGEDKIDLRSIDANTSLGGDQAFSFIGGKAFSGKASELNFAGNVLSGDV
CCHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCEEECCCEEECCC
NGDRIADFQVDIPNVSSLLGTDFYL
CCCEEEEEEECCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]