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The map label for this gene is capL [H]

Identifier: 110632848

GI number: 110632848

Start: 540348

End: 541691

Strand: Reverse

Name: capL [H]

Synonym: Meso_0487

Alternate gene names: 110632848

Gene position: 541691-540348 (Counterclockwise)

Preceding gene: 110632849

Following gene: 110632847

Centisome position: 12.28

GC content: 59.15

Gene sequence:

>1344_bases
ATGGACACGAGCGTCGTAAGCGCCGAAAACATCAAAATCAGGATCGAGTCTCGCGCGGCGACCGCGGGCATCATCGGTCT
GGGTTATGTCGGGCTGCCTTTGGCCGTGGCCGCGGCCAAAGCGGGATATGCGGTATTAGGTTTTGACGTCGACCAATCCA
AAGTCGAAGCCCTGAACGCCGGCAACTCCTATATAGAGGCAGTGCCTGAGCCGTCCTTGCGCGAACAGGTTGCTGTTGGC
CGCTTCGAGGCGACTGCCGATTTTGCGCGCCTCGCCTCATGCGACGTCGTCGTCATTTGCGTGCCGACGCCGCTCACGAA
GCAGCGGGAGCCCGACTTGAGCTTCGTAGAGCAAACCGCATCCGCAATTGCCAGGAATCGCAAGCCCGGTGCCCTCATCA
TCCTCGAATCGACCACTTGGCCCTGGACGACCGAGACGGTCGTCAAGAACATCTTGGAAGCCGACGGCACGAAGAGCGGG
CGTGACTTCTTCCTCGGCTTCTCGCCTGAGCGGGAAGATCCCGGCAATGCCAGCTTCCGAACGGTCACAATCCCGAAGAT
CGTTTCGGGCGACGGGGCAGATGCGCAAGCCCTGGTTGAGGCCTTCTATGGCAATGTAGTGGAGCGCATCGTGCCGGTGT
CTTCTCCTCGGGTAGCTGAGGCAGTGAAGATTACGGAAAACATCTTCCGCGCAGTCAACATCGCGCTCGTCAATGAGCTC
AAGATCATCTACGACGCGATGGACATAGACGTTTGGGAGGTGATCGATGCCGCGGCCACCAAGCCCTTTGGTTTCATGCC
TTTCTATCCGGGCCCCGGACTCGGTGGGCATTGCATCCCAATCGACCCGTTTTATCTCACCTGGAAGGCTCGGGAATACA
ACGTGCCCACCCGCTTCATCGAGCTGGCGGGCGAGATTAACGTTGCCATGCCTCGCTATGTGATCAGCCGGCTTGAGGTC
GCGCTGGATAAGAGCTTCGCCAAATCGCTGAGTGCTTCGAAGGTGCTCATCCTCGGCCTGGCATACAAGAAGAACGTCCC
CGATATCCGCGAAAGCCCGGCCTTCGCCATCATGGACATGCTGAAAGCACGCGGCACGACATTTGACTATCATGACCCCC
ATGTGCCGAGCATTCCACGCACGCGCGAGCACGAGCAGTACTACGGGCAGCGTTCGGTGGGGCTGGATGCGGCGACGATC
TCAAGCTACGACGCAGTCGTCCTCGTGACCGATCATGACGATGTGGACTACGGGCTAGTGGCGGCTAAGGCCAAGCTGGT
GCTGGACACACGGAATGCTTTAGGAAAGCGTGGTTTTAGCGGCGAGACGGTTGTGAAGGCGTGA

Upstream 100 bases:

>100_bases
AAAGCAGCTGTCGTAGTCACCACTCCGAAATTGTGGATTTGTGCCCCTCACGGCCGGAATCCCTGGTTAGATCCCGTTTC
CAACATGGAGGTCCTCCGAC

Downstream 100 bases:

>100_bases
ACTGCAAAGTGAGGTAAGTGGGCCAAATGGCCACTCGGCAAAGGCAAAGATTAGGCTGTAGCCGCTTTGGGATTGTCCTG
TGCTACGCTTGGTAGCCGCT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDTSVVSAENIKIRIESRAATAGIIGLGYVGLPLAVAAAKAGYAVLGFDVDQSKVEALNAGNSYIEAVPEPSLREQVAVG
RFEATADFARLASCDVVVICVPTPLTKQREPDLSFVEQTASAIARNRKPGALIILESTTWPWTTETVVKNILEADGTKSG
RDFFLGFSPEREDPGNASFRTVTIPKIVSGDGADAQALVEAFYGNVVERIVPVSSPRVAEAVKITENIFRAVNIALVNEL
KIIYDAMDIDVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLTWKAREYNVPTRFIELAGEINVAMPRYVISRLEV
ALDKSFAKSLSASKVLILGLAYKKNVPDIRESPAFAIMDMLKARGTTFDYHDPHVPSIPRTREHEQYYGQRSVGLDAATI
SSYDAVVLVTDHDDVDYGLVAAKAKLVLDTRNALGKRGFSGETVVKA

Sequences:

>Translated_447_residues
MDTSVVSAENIKIRIESRAATAGIIGLGYVGLPLAVAAAKAGYAVLGFDVDQSKVEALNAGNSYIEAVPEPSLREQVAVG
RFEATADFARLASCDVVVICVPTPLTKQREPDLSFVEQTASAIARNRKPGALIILESTTWPWTTETVVKNILEADGTKSG
RDFFLGFSPEREDPGNASFRTVTIPKIVSGDGADAQALVEAFYGNVVERIVPVSSPRVAEAVKITENIFRAVNIALVNEL
KIIYDAMDIDVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLTWKAREYNVPTRFIELAGEINVAMPRYVISRLEV
ALDKSFAKSLSASKVLILGLAYKKNVPDIRESPAFAIMDMLKARGTTFDYHDPHVPSIPRTREHEQYYGQRSVGLDAATI
SSYDAVVLVTDHDDVDYGLVAAKAKLVLDTRNALGKRGFSGETVVKA
>Mature_447_residues
MDTSVVSAENIKIRIESRAATAGIIGLGYVGLPLAVAAAKAGYAVLGFDVDQSKVEALNAGNSYIEAVPEPSLREQVAVG
RFEATADFARLASCDVVVICVPTPLTKQREPDLSFVEQTASAIARNRKPGALIILESTTWPWTTETVVKNILEADGTKSG
RDFFLGFSPEREDPGNASFRTVTIPKIVSGDGADAQALVEAFYGNVVERIVPVSSPRVAEAVKITENIFRAVNIALVNEL
KIIYDAMDIDVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLTWKAREYNVPTRFIELAGEINVAMPRYVISRLEV
ALDKSFAKSLSASKVLILGLAYKKNVPDIRESPAFAIMDMLKARGTTFDYHDPHVPSIPRTREHEQYYGQRSVGLDAATI
SSYDAVVLVTDHDDVDYGLVAAKAKLVLDTRNALGKRGFSGETVVKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=467, Percent_Identity=28.2655246252677, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI296040438, Length=375, Percent_Identity=26.9333333333333, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI48994968, Length=409, Percent_Identity=33.2518337408313, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17560350, Length=372, Percent_Identity=26.0752688172043, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136908, Length=370, Percent_Identity=28.1081081081081, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48489; Mature: 48489

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSVVSAENIKIRIESRAATAGIIGLGYVGLPLAVAAAKAGYAVLGFDVDQSKVEALNA
CCCCEEECCCEEEEEECCCCEECEEEHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHC
GNSYIEAVPEPSLREQVAVGRFEATADFARLASCDVVVICVPTPLTKQREPDLSFVEQTA
CCHHEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHH
SAIARNRKPGALIILESTTWPWTTETVVKNILEADGTKSGRDFFLGFSPEREDPGNASFR
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEE
TVTIPKIVSGDGADAQALVEAFYGNVVERIVPVSSPRVAEAVKITENIFRAVNIALVNEL
EEEECEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KIIYDAMDIDVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLTWKAREYNVPTRFI
EEEHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCHHHH
ELAGEINVAMPRYVISRLEVALDKSFAKSLSASKVLILGLAYKKNVPDIRESPAFAIMDM
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHH
LKARGTTFDYHDPHVPSIPRTREHEQYYGQRSVGLDAATISSYDAVVLVTDHDDVDYGLV
HHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHCCCCEEEECCCCEEEEEECCCCCCCCCE
AAKAKLVLDTRNALGKRGFSGETVVKA
EHEEEEEEECHHHHCCCCCCCCCEECC
>Mature Secondary Structure
MDTSVVSAENIKIRIESRAATAGIIGLGYVGLPLAVAAAKAGYAVLGFDVDQSKVEALNA
CCCCEEECCCEEEEEECCCCEECEEEHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHC
GNSYIEAVPEPSLREQVAVGRFEATADFARLASCDVVVICVPTPLTKQREPDLSFVEQTA
CCHHEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHH
SAIARNRKPGALIILESTTWPWTTETVVKNILEADGTKSGRDFFLGFSPEREDPGNASFR
HHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEE
TVTIPKIVSGDGADAQALVEAFYGNVVERIVPVSSPRVAEAVKITENIFRAVNIALVNEL
EEEECEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KIIYDAMDIDVWEVIDAAATKPFGFMPFYPGPGLGGHCIPIDPFYLTWKAREYNVPTRFI
EEEHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCHHHH
ELAGEINVAMPRYVISRLEVALDKSFAKSLSASKVLILGLAYKKNVPDIRESPAFAIMDM
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHH
LKARGTTFDYHDPHVPSIPRTREHEQYYGQRSVGLDAATISSYDAVVLVTDHDDVDYGLV
HHHCCCCCCCCCCCCCCCCCCCCHHHHHCCHHCCCCEEEECCCCEEEEEECCCCCCCCCE
AAKAKLVLDTRNALGKRGFSGETVVKA
EHEEEEEEECHHHHCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]