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The map label for this gene is yrbE [H]

Identifier: 110632504

GI number: 110632504

Start: 177387

End: 178433

Strand: Reverse

Name: yrbE [H]

Synonym: Meso_0142

Alternate gene names: 110632504

Gene position: 178433-177387 (Counterclockwise)

Preceding gene: 110632505

Following gene: 110632503

Centisome position: 4.04

GC content: 61.6

Gene sequence:

>1047_bases
ATGCGTTTGCTCATACTTGGCACAGGCAAGATGGCCAATCAGCATGCCAACCGATTTGCGGCCATTCCCGGCGTGCACAT
CGTCGGCGGTGTCGATATGAATGCAGAGCGCCTCAAGGCCTTCTGCGAACTGCACAAGATCGAGCGCCAGTTCGCCACGG
TGGACGAGGCGCTCGCCTGGGGCGAATTCGACGCGGTCACCAATGTGACGCCCGATGCGGCCCATTACACGACCAGCCTG
GCCTGCATAGCCGCCGGCAAGCATGTGCTTTGCGAAAAGCCGCTCGCCACCAGTTTCGCCGAAGCATCGGAGATGGCGGA
TGCGGCTGAAAAGGCAGGCGTGGTGGCGATGGTCAATCTGAGCTACCGAAATGTTGCGGAGCTTCACGCGGCGCGCGAGC
TGGTGCTTTCCGGCCGCATTGGCGAGGTAAAGCACATAGAAGCCTCCTACCTGCAAAGCTGGCTCGTTTCAAAGACATGG
GGGGACTGGCGCACCGGGCCGCAATGGCTGTGGCGTCTTTCCAAGGGGCACGGCTCCAACGGCACGCTGGGCGATATCGG
CATCCACATCCTCGATTTCGCCTCCTATGGCGCGGCAACCGAGATCGAGACGATCACAAGCCGCCTCAAGACCTTCCCTA
AGGCTGACGGCGACCGGATCGGCGAATATGTTCTCGATGCCAATGACAGTTTTGTCATGACAGCGGGGTTTTCCAACGGA
GCCCTCGGCGTCATCCACGCCACGCGCTGGGCAACGGGCCATCACAATGACCTGCGCGTGCGGATCTATGGCGAAAAGGG
CGGCATCGAGGTGCAGCACACGCTCAAGGAAACGCATCTCAGGGTCTGCCTCGATGAGGACGCCGAGACGGCCACGTGGC
GTGACATGGAAGCCGCGCCCGTGGCGACGAATTACGAGCGCTTCGTCAACGCAGTGCGGCTGAAGATGCCCACCGAGCCG
AGCTTCCGACATGCCGCCGGGCTGCAGCGCATCCTCGACCTGGCTTCCGCTCTGGATGAGACACTTCCTACGCCCGTGCA
TGTTTGA

Upstream 100 bases:

>100_bases
CGCCGAATGTGCCGGTGGAAAAAGCTCCCGAACCCATCACCGAGCGCGGGCCCAAATTGCACAAGCCCGGCGAAGCCGGC
TTCAGATAGGACGACTTCCT

Downstream 100 bases:

>100_bases
CATCCTGTAGCCTCTCTTTCGGGGGAGGCTGCGCCGCAGCGCCGGATGCAGGGTGGCTTTCGCTAGAAGCGCACGAGCCG
CGCAAGCTGCGGAGCCTTCC

Product: oxidoreductase-like

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRLLILGTGKMANQHANRFAAIPGVHIVGGVDMNAERLKAFCELHKIERQFATVDEALAWGEFDAVTNVTPDAAHYTTSL
ACIAAGKHVLCEKPLATSFAEASEMADAAEKAGVVAMVNLSYRNVAELHAARELVLSGRIGEVKHIEASYLQSWLVSKTW
GDWRTGPQWLWRLSKGHGSNGTLGDIGIHILDFASYGAATEIETITSRLKTFPKADGDRIGEYVLDANDSFVMTAGFSNG
ALGVIHATRWATGHHNDLRVRIYGEKGGIEVQHTLKETHLRVCLDEDAETATWRDMEAAPVATNYERFVNAVRLKMPTEP
SFRHAAGLQRILDLASALDETLPTPVHV

Sequences:

>Translated_348_residues
MRLLILGTGKMANQHANRFAAIPGVHIVGGVDMNAERLKAFCELHKIERQFATVDEALAWGEFDAVTNVTPDAAHYTTSL
ACIAAGKHVLCEKPLATSFAEASEMADAAEKAGVVAMVNLSYRNVAELHAARELVLSGRIGEVKHIEASYLQSWLVSKTW
GDWRTGPQWLWRLSKGHGSNGTLGDIGIHILDFASYGAATEIETITSRLKTFPKADGDRIGEYVLDANDSFVMTAGFSNG
ALGVIHATRWATGHHNDLRVRIYGEKGGIEVQHTLKETHLRVCLDEDAETATWRDMEAAPVATNYERFVNAVRLKMPTEP
SFRHAAGLQRILDLASALDETLPTPVHV
>Mature_348_residues
MRLLILGTGKMANQHANRFAAIPGVHIVGGVDMNAERLKAFCELHKIERQFATVDEALAWGEFDAVTNVTPDAAHYTTSL
ACIAAGKHVLCEKPLATSFAEASEMADAAEKAGVVAMVNLSYRNVAELHAARELVLSGRIGEVKHIEASYLQSWLVSKTW
GDWRTGPQWLWRLSKGHGSNGTLGDIGIHILDFASYGAATEIETITSRLKTFPKADGDRIGEYVLDANDSFVMTAGFSNG
ALGVIHATRWATGHHNDLRVRIYGEKGGIEVQHTLKETHLRVCLDEDAETATWRDMEAAPVATNYERFVNAVRLKMPTEP
SFRHAAGLQRILDLASALDETLPTPVHV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI1787574, Length=328, Percent_Identity=27.4390243902439, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 38064; Mature: 38064

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLILGTGKMANQHANRFAAIPGVHIVGGVDMNAERLKAFCELHKIERQFATVDEALAW
CEEEEEECCCHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GEFDAVTNVTPDAAHYTTSLACIAAGKHVLCEKPLATSFAEASEMADAAEKAGVVAMVNL
CCCCHHCCCCCCHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHHHHHHHCCEEEEEEC
SYRNVAELHAARELVLSGRIGEVKHIEASYLQSWLVSKTWGDWRTGPQWLWRLSKGHGSN
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
GTLGDIGIHILDFASYGAATEIETITSRLKTFPKADGDRIGEYVLDANDSFVMTAGFSNG
CCCHHHHHEEEEHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCEEEEECCCCC
ALGVIHATRWATGHHNDLRVRIYGEKGGIEVQHTLKETHLRVCLDEDAETATWRDMEAAP
CEEEEEEEEECCCCCCCEEEEEEECCCCEEHHHHHHHHHEEEEECCCCCCCCCCCCCCCC
VATNYERFVNAVRLKMPTEPSFRHAAGLQRILDLASALDETLPTPVHV
CCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRLLILGTGKMANQHANRFAAIPGVHIVGGVDMNAERLKAFCELHKIERQFATVDEALAW
CEEEEEECCCHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GEFDAVTNVTPDAAHYTTSLACIAAGKHVLCEKPLATSFAEASEMADAAEKAGVVAMVNL
CCCCHHCCCCCCHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHHHHHHHCCEEEEEEC
SYRNVAELHAARELVLSGRIGEVKHIEASYLQSWLVSKTWGDWRTGPQWLWRLSKGHGSN
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
GTLGDIGIHILDFASYGAATEIETITSRLKTFPKADGDRIGEYVLDANDSFVMTAGFSNG
CCCHHHHHEEEEHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCEEEEECCCCC
ALGVIHATRWATGHHNDLRVRIYGEKGGIEVQHTLKETHLRVCLDEDAETATWRDMEAAP
CEEEEEEEEECCCCCCCEEEEEEECCCCEEHHHHHHHHHEEEEECCCCCCCCCCCCCCCC
VATNYERFVNAVRLKMPTEPSFRHAAGLQRILDLASALDETLPTPVHV
CCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]