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The map label for this gene is uvrD [H]

Identifier: 109948205

GI number: 109948205

Start: 1511418

End: 1513463

Strand: Reverse

Name: uvrD [H]

Synonym: Hac_1738

Alternate gene names: 109948205

Gene position: 1513463-1511418 (Counterclockwise)

Preceding gene: 109948206

Following gene: 109948204

Centisome position: 97.4

GC content: 38.91

Gene sequence:

>2046_bases
ATGGATTTTGCAAAAAGTATTTTAGACAATTTAAATGAAGCGCAAAAAATCGCCGCATGCCACATTCAAGGGCCTTTGTT
GATTTTAGCTGGAGCTGGGAGCGGTAAGACTAAGACTTTAACGAGCCGTTTAGCGTATTTGATTGGGGCTTGTGGCGTGC
CTAGCGAGAACACTTTAACGCTCACTTTCACCAATAAAGCGAGCAAAGAAATGCAAGAAAGGGCTTTGAAATTATTGAAA
AACCAAGCGTTTATCCCCCCTTTGCTTTGCACTTTCCATCGTTTTGGTTTGTTGTTTTTAAGACAACACATGAGCCTTTT
AAAAAGGGCGTGCGATTTTTCGGTGCTAGATAGCGATGAGGTTAAAACGCTTTGCAAACAGCTCAAAATTTCAGGTTTTA
GAGCCAATATTTCTCAAATCAAAAACGGCATGATTGATTTAAATACACAAGACACAGAATGCTATAAAGCGTATGATCTT
TATCAAAATGCCTTAAAAAAAGACAATTTAGTGGATTTTGACGATTTGCTTTTTTTAAGCCTTAAGATTTTACAAGACAA
TGAAAAGCTCGCCAAAGAAACTAGTGAGCACTACCATTATATTATGGTAGATGAGTATCAAGACACGAACGCCTTGCAAC
TAGAGTTTTTAAAAATATTGAGTTTCACGCATAATAATTTGTGCGTGGTGGGCGATGATGATCAAAGCATTTATGGTTTT
AGGGGGGCGGATATTTCTAATATTTTAAATTTTTCCAAGCATTTTAAGAGGGCTAAAGTGGTGAAATTAGAGACCAACTA
CCGCTCCAGCGCTGAAATTTTAAAGTGCGCTAACGCGCTCATTAGCCACAACCAAAACCGCCACAAAAAAACGCTCCAGA
GTTTTAAAGGCTCGCGTAAAAGCGTCATTTGTAAAGAGTATTTGACGCAAAAAGAAGAGAGCCTGGATGTGGCTTATCAA
ATCAAAGCCCTTTTAAATAAGGGTGAAAATTTAGAAAATATCGCTATTTTGTACCGCTTAAACGGGCTTAGCCGCAACAT
TGAAGAGAGCTTGAACGCTTTGAATATCCCTTATAGGCTTATCGGAGCGGTGAGTTTCTATGAAAGAGCGGAGATTAAAG
ACGCTCTGGCGTTCATGCATGCAGTGGCCAAAAAAGACGATCGCTTTTTTATCAAGCGCATTTTAAACAAGCCCCCAAGA
GGCCTTGGCAAGATCACTCAAGAATTGATTTTTTCTCTTTTAGATGAGAAGGACTTGAATTTAGAAGAAGCGCTAAAACT
CGGGGCGTTTAAAGACAAATTGAACCCTAAAAACGAATACGCTTTAAAGAAATTCACCGCCATGATAGGGCGATTAAGGG
AGGCTTTTGAATTTTCTGTAGAGAAGTTTTGCGAGCGTTTTTTAGAAGAGACTAATCTGTTAAAAAGCTATGAAAAAGAA
GACAATTACGAAGAAAGAGAGGGCTTTGTCAAAGAGCTTTTAAGCTTAGTGAAAGAGCATTTTAAAACTAACCCCACGCA
TTCTTTGTTAGACTTTTTAAATGAAAGCGTGCTGGATGTCCATAACACAGAAAACGCGCATAAAGTGAGTTGCATGAGCG
TGCATATGAGTAAGGGCTTGGAATTTAAGCATGTGTTTGTGATTGGGTTAGAAGAAGGGTTTTTCCCGCATAGGGGGTTT
AATCAAGAAAGCGATTTGGAAGAAGAAAGGCGCTTGGCTTATGTGGCCATCACTAGGGCTAAAGAAGAATTGCAACTTTC
TTATGTTAAAGAGCGTTCGTATTTTGGGAAAAAAATCACCTGTTTGCCCTCTTCATTTTTAGAAGAAGCTCAGTTGCTCC
AACAAAATAAACCCCCTAAACACGATCACAAAAAAAACACGCCCATTAAAGTGGGGGATTTGATCAAGCATAAGATTTTT
GGTACCGGAAGGGTTTTGGGCGTAGAAAAAGGCTTGAGCGGTTTGTGTTTTAAAATCAATTGCGGGGGGAATGTCTATGA
TAAAATTTCAGAAAAATTTGTAGAAAAAGTGGGTAGCGGATTTTGA

Upstream 100 bases:

>100_bases
AAACCTCTGATTTTTTTTCGCCTTATTTTGATTTTGAAATTGATACCAACCTTTTAAAAGAGCGTTTGAACCAAGAAAAA
AAGGGCGAGTTTTTAGAATA

Downstream 100 bases:

>100_bases
AAATTTTCATTCTTTTTTTCATGGCTTTAAACGCGCTATTGGCTATGGATACTAATACGCTTAAAACAGAGATTAAAGCA
ATTTATCTTAAAGAATACAA

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MDFAKSILDNLNEAQKIAACHIQGPLLILAGAGSGKTKTLTSRLAYLIGACGVPSENTLTLTFTNKASKEMQERALKLLK
NQAFIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDEVKTLCKQLKISGFRANISQIKNGMIDLNTQDTECYKAYDL
YQNALKKDNLVDFDDLLFLSLKILQDNEKLAKETSEHYHYIMVDEYQDTNALQLEFLKILSFTHNNLCVVGDDDQSIYGF
RGADISNILNFSKHFKRAKVVKLETNYRSSAEILKCANALISHNQNRHKKTLQSFKGSRKSVICKEYLTQKEESLDVAYQ
IKALLNKGENLENIAILYRLNGLSRNIEESLNALNIPYRLIGAVSFYERAEIKDALAFMHAVAKKDDRFFIKRILNKPPR
GLGKITQELIFSLLDEKDLNLEEALKLGAFKDKLNPKNEYALKKFTAMIGRLREAFEFSVEKFCERFLEETNLLKSYEKE
DNYEEREGFVKELLSLVKEHFKTNPTHSLLDFLNESVLDVHNTENAHKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRGF
NQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGKKITCLPSSFLEEAQLLQQNKPPKHDHKKNTPIKVGDLIKHKIF
GTGRVLGVEKGLSGLCFKINCGGNVYDKISEKFVEKVGSGF

Sequences:

>Translated_681_residues
MDFAKSILDNLNEAQKIAACHIQGPLLILAGAGSGKTKTLTSRLAYLIGACGVPSENTLTLTFTNKASKEMQERALKLLK
NQAFIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDEVKTLCKQLKISGFRANISQIKNGMIDLNTQDTECYKAYDL
YQNALKKDNLVDFDDLLFLSLKILQDNEKLAKETSEHYHYIMVDEYQDTNALQLEFLKILSFTHNNLCVVGDDDQSIYGF
RGADISNILNFSKHFKRAKVVKLETNYRSSAEILKCANALISHNQNRHKKTLQSFKGSRKSVICKEYLTQKEESLDVAYQ
IKALLNKGENLENIAILYRLNGLSRNIEESLNALNIPYRLIGAVSFYERAEIKDALAFMHAVAKKDDRFFIKRILNKPPR
GLGKITQELIFSLLDEKDLNLEEALKLGAFKDKLNPKNEYALKKFTAMIGRLREAFEFSVEKFCERFLEETNLLKSYEKE
DNYEEREGFVKELLSLVKEHFKTNPTHSLLDFLNESVLDVHNTENAHKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRGF
NQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGKKITCLPSSFLEEAQLLQQNKPPKHDHKKNTPIKVGDLIKHKIF
GTGRVLGVEKGLSGLCFKINCGGNVYDKISEKFVEKVGSGF
>Mature_681_residues
MDFAKSILDNLNEAQKIAACHIQGPLLILAGAGSGKTKTLTSRLAYLIGACGVPSENTLTLTFTNKASKEMQERALKLLK
NQAFIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDEVKTLCKQLKISGFRANISQIKNGMIDLNTQDTECYKAYDL
YQNALKKDNLVDFDDLLFLSLKILQDNEKLAKETSEHYHYIMVDEYQDTNALQLEFLKILSFTHNNLCVVGDDDQSIYGF
RGADISNILNFSKHFKRAKVVKLETNYRSSAEILKCANALISHNQNRHKKTLQSFKGSRKSVICKEYLTQKEESLDVAYQ
IKALLNKGENLENIAILYRLNGLSRNIEESLNALNIPYRLIGAVSFYERAEIKDALAFMHAVAKKDDRFFIKRILNKPPR
GLGKITQELIFSLLDEKDLNLEEALKLGAFKDKLNPKNEYALKKFTAMIGRLREAFEFSVEKFCERFLEETNLLKSYEKE
DNYEEREGFVKELLSLVKEHFKTNPTHSLLDFLNESVLDVHNTENAHKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRGF
NQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGKKITCLPSSFLEEAQLLQQNKPPKHDHKKNTPIKVGDLIKHKIF
GTGRVLGVEKGLSGLCFKINCGGNVYDKISEKFVEKVGSGF

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=689, Percent_Identity=32.2206095791001, Blast_Score=348, Evalue=9e-97,
Organism=Escherichia coli, GI48994965, Length=635, Percent_Identity=35.2755905511811, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1787196, Length=186, Percent_Identity=32.7956989247312, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322369, Length=469, Percent_Identity=29.2110874200426, Blast_Score=154, Evalue=5e-38,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77776; Mature: 77776

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAKSILDNLNEAQKIAACHIQGPLLILAGAGSGKTKTLTSRLAYLIGACGVPSENTLT
CCHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEE
LTFTNKASKEMQERALKLLKNQAFIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDE
EEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
VKTLCKQLKISGFRANISQIKNGMIDLNTQDTECYKAYDLYQNALKKDNLVDFDDLLFLS
HHHHHHHHHHCCHHCCHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LKILQDNEKLAKETSEHYHYIMVDEYQDTNALQLEFLKILSFTHNNLCVVGDDDQSIYGF
HHHHCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
RGADISNILNFSKHFKRAKVVKLETNYRSSAEILKCANALISHNQNRHKKTLQSFKGSRK
CCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
SVICKEYLTQKEESLDVAYQIKALLNKGENLENIAILYRLNGLSRNIEESLNALNIPYRL
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCHHH
IGAVSFYERAEIKDALAFMHAVAKKDDRFFIKRILNKPPRGLGKITQELIFSLLDEKDLN
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
LEEALKLGAFKDKLNPKNEYALKKFTAMIGRLREAFEFSVEKFCERFLEETNLLKSYEKE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DNYEEREGFVKELLSLVKEHFKTNPTHSLLDFLNESVLDVHNTENAHKVSCMSVHMSKGL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHEEHHHCCC
EFKHVFVIGLEEGFFPHRGFNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGKKIT
CEEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCEEE
CLPSSFLEEAQLLQQNKPPKHDHKKNTPIKVGDLIKHKIFGTGRVLGVEKGLSGLCFKIN
ECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEE
CGGNVYDKISEKFVEKVGSGF
CCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDFAKSILDNLNEAQKIAACHIQGPLLILAGAGSGKTKTLTSRLAYLIGACGVPSENTLT
CCHHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEE
LTFTNKASKEMQERALKLLKNQAFIPPLLCTFHRFGLLFLRQHMSLLKRACDFSVLDSDE
EEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
VKTLCKQLKISGFRANISQIKNGMIDLNTQDTECYKAYDLYQNALKKDNLVDFDDLLFLS
HHHHHHHHHHCCHHCCHHHHCCCCEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LKILQDNEKLAKETSEHYHYIMVDEYQDTNALQLEFLKILSFTHNNLCVVGDDDQSIYGF
HHHHCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
RGADISNILNFSKHFKRAKVVKLETNYRSSAEILKCANALISHNQNRHKKTLQSFKGSRK
CCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
SVICKEYLTQKEESLDVAYQIKALLNKGENLENIAILYRLNGLSRNIEESLNALNIPYRL
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCHHH
IGAVSFYERAEIKDALAFMHAVAKKDDRFFIKRILNKPPRGLGKITQELIFSLLDEKDLN
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCC
LEEALKLGAFKDKLNPKNEYALKKFTAMIGRLREAFEFSVEKFCERFLEETNLLKSYEKE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DNYEEREGFVKELLSLVKEHFKTNPTHSLLDFLNESVLDVHNTENAHKVSCMSVHMSKGL
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHEEHHHCCC
EFKHVFVIGLEEGFFPHRGFNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGKKIT
CEEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCEEE
CLPSSFLEEAQLLQQNKPPKHDHKKNTPIKVGDLIKHKIFGTGRVLGVEKGLSGLCFKIN
ECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEE
CGGNVYDKISEKFVEKVGSGF
CCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]