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The map label for this gene is tmk

Identifier: 109948201

GI number: 109948201

Start: 1509142

End: 1509717

Strand: Reverse

Name: tmk

Synonym: Hac_1734

Alternate gene names: 109948201

Gene position: 1509717-1509142 (Counterclockwise)

Preceding gene: 109948202

Following gene: 109948200

Centisome position: 97.15

GC content: 39.24

Gene sequence:

>576_bases
ATGTATGTGGTGTTAGAAGGCATTGATGGCGTGGGCAAAAGCACTCAAATAGAATTGTTAAAAAGCGCGTTTCAAAACGC
CCTTTTTACCAAAGAGCCAGGGGGGACAAAAATAGGCGAAACTTTAAGGCATATAGCTTTACATGAAAACCTCAGCGAGT
TAGCCAGAGCGTTTTTATTCTTAAGCGATAGGGCTGAGCATATAGAAAGCGTTATCAAACCGGCTTTAAAAGAAAAAAAA
CTCATCATTAGCGATAGGAGTTTGATCTCTGGCATGGCTTATAGCGCATTTTCAAGCTTGGAATTAAACCTGCTTGCCAC
TCAAAGCATCTTACCCGCAAAAATCATTCTTTTATGGATAGACAAAGAGGGCTTAAAAGAGCGCTTAAGCCTTAAAAGCT
TGGACAAAATAGAAAACCAAGGCGTAGAAAAATTACTCCATATCCAGCAAAAGTTCAAAACGCATGCTTATGCTTTAAAA
GAACAATTTGGGTGCGAGGTTTTGGAATTAAACGCTAAAGAAAACGCCAAAAATTTGCATGAGCGAATCAGCGCCTTTAT
CCAATGCGTTGTTTAA

Upstream 100 bases:

>100_bases
TTTATTAGCTCTTCTATTGTGCGATCCATTATCGCTCATAAGGGCGATGCGAGCCATTTAGTGCCTAAAGAAATTTACCC
TTTTATTTCAAAGGTTTAAA

Downstream 100 bases:

>100_bases
CTTGTTTAAGGCTCTCTTTCAAGCCCCTTTGCCAGAATTGCTTGAACGATTTGCCCTTAAGCTTAAAAGTAAGGGTTTTA
GAGGGCGTGAGCGTGTATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MYVVLEGIDGVGKSTQIELLKSAFQNALFTKEPGGTKIGETLRHIALHENLSELARAFLFLSDRAEHIESVIKPALKEKK
LIISDRSLISGMAYSAFSSLELNLLATQSILPAKIILLWIDKEGLKERLSLKSLDKIENQGVEKLLHIQQKFKTHAYALK
EQFGCEVLELNAKENAKNLHERISAFIQCVV

Sequences:

>Translated_191_residues
MYVVLEGIDGVGKSTQIELLKSAFQNALFTKEPGGTKIGETLRHIALHENLSELARAFLFLSDRAEHIESVIKPALKEKK
LIISDRSLISGMAYSAFSSLELNLLATQSILPAKIILLWIDKEGLKERLSLKSLDKIENQGVEKLLHIQQKFKTHAYALK
EQFGCEVLELNAKENAKNLHERISAFIQCVV
>Mature_191_residues
MYVVLEGIDGVGKSTQIELLKSAFQNALFTKEPGGTKIGETLRHIALHENLSELARAFLFLSDRAEHIESVIKPALKEKK
LIISDRSLISGMAYSAFSSLELNLLATQSILPAKIILLWIDKEGLKERLSLKSLDKIENQGVEKLLHIQQKFKTHAYALK
EQFGCEVLELNAKENAKNLHERISAFIQCVV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=158, Percent_Identity=32.9113924050633, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_HELAH (Q17V96)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_665429.1
- ProteinModelPortal:   Q17V96
- STRING:   Q17V96
- GeneID:   4177484
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_1734
- NMPDR:   fig|382638.8.peg.1677
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   DRAEHYE
- ProtClustDB:   PRK00698
- BioCyc:   HACI382638:HAC_1734-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21411; Mature: 21411

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVLEGIDGVGKSTQIELLKSAFQNALFTKEPGGTKIGETLRHIALHENLSELARAFLF
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSAFSSLELNLLATQSILPAKIILLWI
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DKEGLKERLSLKSLDKIENQGVEKLLHIQQKFKTHAYALKEQFGCEVLELNAKENAKNLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
ERISAFIQCVV
HHHHHHHHHCC
>Mature Secondary Structure
MYVVLEGIDGVGKSTQIELLKSAFQNALFTKEPGGTKIGETLRHIALHENLSELARAFLF
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSAFSSLELNLLATQSILPAKIILLWI
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DKEGLKERLSLKSLDKIENQGVEKLLHIQQKFKTHAYALKEQFGCEVLELNAKENAKNLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
ERISAFIQCVV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA