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The map label for this gene is folP [H]

Identifier: 109948121

GI number: 109948121

Start: 1430294

End: 1431436

Strand: Reverse

Name: folP [H]

Synonym: Hac_1643

Alternate gene names: 109948121

Gene position: 1431436-1430294 (Counterclockwise)

Preceding gene: 109948122

Following gene: 109948119

Centisome position: 92.12

GC content: 39.28

Gene sequence:

>1143_bases
ATGACTTTAAAACGCCTTAATTCTGATGCGTTAAAAAACGCCCTTCAAAAAATAGGTCCAGAAAAGATCGTGCAAAACCG
CATGCACCAAAAAGGCGTTAGCTTTGTCTTTGAAATCAAACATTTGCCCTTGAGTGCTGCGTTGATTTTAAAGCAAGAAG
CCATAAGTGTTGGAGGCGATTTTGCCACGCCAAAAGATTGTATTTTGGCTAAAGAGCCTTTTTATGATGGGGTGTTGATC
GTGAGCGCTAATCAATTAGAGCGTTTGATTATAAAGTGCTATTCCCAACCCTTTGGGCTTAAACATTTAGCGCAAGAATT
GAAAAGCCATCTCAAAGCCCCTAAACCTAACGCCCCACAGATCATGGCGGTTTTAAACCTTACGCCGGATAGCTTCTATG
AAAAGAGCCGTTTTAGTAGCAAAAAAGCGCTTGAAGAAATCTATCAATTACTAGAAAAGGGCATCACACTCATTGATATA
GGTGCAGCCAGTTCAAGACCACAGAGTGAAATCATTGATCCAAAAATAGAGCAAGAGCGCTTAAAAGAAGTTTTATTGGA
AATCAAATCCCAAAAACTCTACCAACTTGCGCAATTTAGCATAGACACCTACCATGCCAAAACCGCCCAAATGGCTTTGG
AGCATCATTTTTCTATCCTTAATGATGTGAGCGGTTTTAGTAGCGCTGAAATGCTAGAAGTCGCAAGAGACTACAAACCT
ACTTGCATTTTAATGCACTCTCAAAAAACCCCCAAAGACATGCAAGAAAATGTGTTTTACCATAATCTATTTGACGAAAT
GGATCGTTTCTTTAAAGACAAGCTAGAGGTTTTAGAAAAATATGCACTTCAAGATATTGTTTTAGATATTGGGTTTGGAT
TCGCTAAATTAAAAGAGCATAATTTAGCCTTAATCAAGCATTTAAGCCACTTCCTCAAATTCAAAAAACCCTTATTGGTG
GGAGCGAGCCGTAAAAACACGATCGGGCTTATCACCGGGCGTGAAGTTCAAAACCGACTCGCTGGCACTTTAAGCTTGCA
TTTAATGGCGTTACAAAATGGAGCGAGCATTTTAAGAGTGCATGATATTGATGAGCATATTGATCTCATTAAAGTGTTTG
AGAGCCTAGAAGAGACAGATTAG

Upstream 100 bases:

>100_bases
AAGCTTTTGATTTAGCGATCAAGGCCAATAGCTCTTATTATAAGCTTAGCTATAATCTTTTGCCCTTACTTTTAAGCCTT
TTGTCTAAAAAGAGGGTGTG

Downstream 100 bases:

>100_bases
ATAAAATTTTTGGCTCTGATCTTAATGAATATTAGCTATTACAAAAAACACTTTTGAGTATTTTTTAATAACCAATACTC
TATTTTAACCCTAACGCTTA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTLKRLNSDALKNALQKIGPEKIVQNRMHQKGVSFVFEIKHLPLSAALILKQEAISVGGDFATPKDCILAKEPFYDGVLI
VSANQLERLIIKCYSQPFGLKHLAQELKSHLKAPKPNAPQIMAVLNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDI
GAASSRPQSEIIDPKIEQERLKEVLLEIKSQKLYQLAQFSIDTYHAKTAQMALEHHFSILNDVSGFSSAEMLEVARDYKP
TCILMHSQKTPKDMQENVFYHNLFDEMDRFFKDKLEVLEKYALQDIVLDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRVHDIDEHIDLIKVFESLEETD

Sequences:

>Translated_380_residues
MTLKRLNSDALKNALQKIGPEKIVQNRMHQKGVSFVFEIKHLPLSAALILKQEAISVGGDFATPKDCILAKEPFYDGVLI
VSANQLERLIIKCYSQPFGLKHLAQELKSHLKAPKPNAPQIMAVLNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDI
GAASSRPQSEIIDPKIEQERLKEVLLEIKSQKLYQLAQFSIDTYHAKTAQMALEHHFSILNDVSGFSSAEMLEVARDYKP
TCILMHSQKTPKDMQENVFYHNLFDEMDRFFKDKLEVLEKYALQDIVLDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLV
GASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRVHDIDEHIDLIKVFESLEETD
>Mature_379_residues
TLKRLNSDALKNALQKIGPEKIVQNRMHQKGVSFVFEIKHLPLSAALILKQEAISVGGDFATPKDCILAKEPFYDGVLIV
SANQLERLIIKCYSQPFGLKHLAQELKSHLKAPKPNAPQIMAVLNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDIG
AASSRPQSEIIDPKIEQERLKEVLLEIKSQKLYQLAQFSIDTYHAKTAQMALEHHFSILNDVSGFSSAEMLEVARDYKPT
CILMHSQKTPKDMQENVFYHNLFDEMDRFFKDKLEVLEKYALQDIVLDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLVG
ASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRVHDIDEHIDLIKVFESLEETD

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=34.0996168582375, Blast_Score=150, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=27.5316455696203, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 43115; Mature: 42984

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKRLNSDALKNALQKIGPEKIVQNRMHQKGVSFVFEIKHLPLSAALILKQEAISVGGD
CCHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHCCCC
FATPKDCILAKEPFYDGVLIVSANQLERLIIKCYSQPFGLKHLAQELKSHLKAPKPNAPQ
CCCCHHHEEECCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
IMAVLNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDIGAASSRPQSEIIDPKIEQER
EEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCHHHHH
LKEVLLEIKSQKLYQLAQFSIDTYHAKTAQMALEHHFSILNDVSGFSSAEMLEVARDYKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
TCILMHSQKTPKDMQENVFYHNLFDEMDRFFKDKLEVLEKYALQDIVLDIGFGFAKLKEH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRV
HHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECHHHHHHHHHHHHHHHHEECCCCCEEEE
HDIDEHIDLIKVFESLEETD
ECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLKRLNSDALKNALQKIGPEKIVQNRMHQKGVSFVFEIKHLPLSAALILKQEAISVGGD
CHHHCCHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHCCCC
FATPKDCILAKEPFYDGVLIVSANQLERLIIKCYSQPFGLKHLAQELKSHLKAPKPNAPQ
CCCCHHHEEECCCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
IMAVLNLTPDSFYEKSRFSSKKALEEIYQLLEKGITLIDIGAASSRPQSEIIDPKIEQER
EEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHCCCCCHHHHH
LKEVLLEIKSQKLYQLAQFSIDTYHAKTAQMALEHHFSILNDVSGFSSAEMLEVARDYKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
TCILMHSQKTPKDMQENVFYHNLFDEMDRFFKDKLEVLEKYALQDIVLDIGFGFAKLKEH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQNRLAGTLSLHLMALQNGASILRV
HHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECHHHHHHHHHHHHHHHHEECCCCCEEEE
HDIDEHIDLIKVFESLEETD
ECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]