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The map label for this gene is uppS [H]

Identifier: 109948079

GI number: 109948079

Start: 1391509

End: 1392180

Strand: Reverse

Name: uppS [H]

Synonym: Hac_1597

Alternate gene names: 109948079

Gene position: 1392180-1391509 (Counterclockwise)

Preceding gene: 109948080

Following gene: 109948078

Centisome position: 89.59

GC content: 36.46

Gene sequence:

>672_bases
ATGGATGGTAATGGCAGGTGGGCTAGATTAAAGAATAAAGCTAGGGCTTATGGGCATAAAAAGGGCGTAAAAACCCTTAA
AGACATTACGATATGGTGTGCTAACTATAAATTAGAATGCTTGACGCTATACGCTTTTTCTACGGAAAATTGGAAACGCC
CCAAAAGTGAAGTGGATTTTTTAATGAAAATGCTTAAAAAATACCTTAAAGATGAGCGATCCACTTACTTGAATAATAAT
ATACGCTTCAGAGCGATAGGGGATTTAGAGGGCTTTTCTAAAGAATTGAGAGACACGATCTTACAACTTGAAAGCGATAC
TAGGTATTTTAAGGATTTTACGCAAGTTTTAGCCCTTAATTATGGCTCTAAAAACGAGCTTTCAAGGGCTTTTAAAAGCT
TACTAGAGAATCCACCTGATAATATAGAGTCTTTAGAAAGCTTGGAAAATGAAATCTCCAATCGTTTAGACACGCATGAT
TTACCGGAAGTGGATTTATTGTTAAGAACAGGGGGGGAAATGCGCTTGTCTAATTTTTTATTGTGGCAGTCTAGCTATGC
GGAATTGTTTTTCACACCGATTTTATGGCCTGATTTCACCCCTAAAGATTTAGAAAACATCATTAGCGATTTTTATAAAA
GAGTGCGCAAATTCGGGGAATTAAAATGCTAG

Upstream 100 bases:

>100_bases
TTTAGTGGATGCTTGCACGCTTTAAATGGTGTATAATTTTAAAGATTTTCTTTAAAAGGTAAAGGCATTGGATAACACTC
TCAAACATCTTGCCATTATT

Downstream 100 bases:

>100_bases
TAGAAATAGAAAATTTGACTAAAACCTATGGGAGTTTAAAAGCGTTAGACAATATCCATTTGAAACTACCCAAACAGCAA
TTTATAGGGCTTTTAGGCCC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MDGNGRWARLKNKARAYGHKKGVKTLKDITIWCANYKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYLKDERSTYLNNN
IRFRAIGDLEGFSKELRDTILQLESDTRYFKDFTQVLALNYGSKNELSRAFKSLLENPPDNIESLESLENEISNRLDTHD
LPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC

Sequences:

>Translated_223_residues
MDGNGRWARLKNKARAYGHKKGVKTLKDITIWCANYKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYLKDERSTYLNNN
IRFRAIGDLEGFSKELRDTILQLESDTRYFKDFTQVLALNYGSKNELSRAFKSLLENPPDNIESLESLENEISNRLDTHD
LPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
>Mature_223_residues
MDGNGRWARLKNKARAYGHKKGVKTLKDITIWCANYKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYLKDERSTYLNNN
IRFRAIGDLEGFSKELRDTILQLESDTRYFKDFTQVLALNYGSKNELSRAFKSLLENPPDNIESLESLENEISNRLDTHD
LPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=37.3873873873874, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=37.3873873873874, Blast_Score=130, Evalue=9e-31,
Organism=Escherichia coli, GI1786371, Length=225, Percent_Identity=42.2222222222222, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71993029, Length=207, Percent_Identity=34.2995169082126, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=230, Percent_Identity=30, Blast_Score=95, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=31.0185185185185, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18857969, Length=204, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26278; Mature: 26278

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGNGRWARLKNKARAYGHKKGVKTLKDITIWCANYKLECLTLYAFSTENWKRPKSEVDF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHH
LMKMLKKYLKDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLESDTRYFKDFTQVLALN
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
YGSKNELSRAFKSLLENPPDNIESLESLENEISNRLDTHDLPEVDLLLRTGGEMRLSNFL
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHH
LWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDGNGRWARLKNKARAYGHKKGVKTLKDITIWCANYKLECLTLYAFSTENWKRPKSEVDF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHH
LMKMLKKYLKDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLESDTRYFKDFTQVLALN
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
YGSKNELSRAFKSLLENPPDNIESLESLENEISNRLDTHDLPEVDLLLRTGGEMRLSNFL
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHH
LWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]