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The map label for this gene is yvgW [H]

Identifier: 109947461

GI number: 109947461

Start: 797947

End: 800007

Strand: Reverse

Name: yvgW [H]

Synonym: Hac_0913

Alternate gene names: 109947461

Gene position: 800007-797947 (Counterclockwise)

Preceding gene: 109947462

Following gene: 109947460

Centisome position: 51.48

GC content: 41.05

Gene sequence:

>2061_bases
ATGCAAGAATACCACATTCACAATTTGGATTGCCCTGATTGTGCAGCTAAATTGGAAAGGGATTTAAACAAACTGGACTG
TGTGAAAAAAGCTCAAATCAATTTTAGCACCAGCAAGTTGTTTTTGGATACGAGCGATTTTGAAAAGGTTAAGGCTTTCA
TTAAGCAAAACGAACCGCATTTGAGCCTGTCTTTTAAAGAAGCCGTAGAAAAGCCCTTGAGTTTTACCCCACTCATTACG
ACAATTATTGTCTTTTTAGGCGCGATTTTAATCTTACGCTTAAACCCTAGCGCTTTCATTGAAAAGGCGGTGTTTGTGGT
GTTAGCTTTAGTGTATCTCATAAGCGGTAAAGATGTGATTTTAGGGGCGTTTCGTGGGCTTAGAAAAGGGCAATTCTTTG
ATGAAAACGCTCTCATGCTCATTGCGACTATTGCGGCTTTTTGCGTGGGGGCTTATGAAGAGAGTGTGTCTATTATTGTG
TTTTATTCAGCGGGTGAGTTTTTGCAAAAACTCGCTATCTCGCGCTCTAAAAAATCCCTTAAGGCTTTAGTGGATGTCGC
CCCTAATTTAGCCTACTTGAAAAAGGGCGATGAATTGGTGAGTGTTACGCCTGAAGATTTGCAAATCAATGATATTGTGG
TGGTGAAAGTTGGCGAAAAAGTGCCTGTTGATGGCGTGGTGATTAAAGGCGAGAGTTTGCTAGATGAAAGGGCGTTGAGT
GGGGAGTCCATGCCTATTAATGTCAGTGAAAACTCTAAAGTGCTTGGGGGGAGTTTGAATTTAAAGGCGGTGCTTGAAAT
TAAAGTAGAAAAAATTTATAAAGATTCTTCTATCGCTAAAGTGGTGGATTTAGTCCAACAAGCCACGAATGAAAAGAGTG
AAACAGAGAAATTTATCACTAAATTTTCACGCTACTACACCCCAAGCGTTTTATTTATTGCGTTAATGATCGCTGTATTA
CCGCCCTTGTTTTCTATGGGGAGCTTTGATGAGTGGATTTATAGGGGGCTTGTGGCTTTAATGGTGAGCTGTCCTTGTGC
ATTAGTGATTTCTGTGCCTTTAGGGTATTTTGGAGGCGTGGGAGCGGCGAGTAGGAAAGGTATTTTGATGAAAGGTGTGC
ATGTTTTAGAGGTACTTACCCAAGCTAAAAGCATCGCCTTTGATAAAACCGGCACCTTAACTAAAGGCGTTTTTAAAGTG
ATGGATATTGTGCCACAAAACAGGCATTCTAAAGAAGAAGTTTTGCATTACGCTTCTTGTTCGCAGCTCTTATCCACGCA
CCCAATTGCTTTATCCATTCAAAAAGCTTGCGAGGAAATGTTAAAAGACAATCAGCACCAACATGACATTAAAAATTACG
AAGAATTGAGCGGAATGGGGGTTAAAGCGCAATGCCATGCGGATTTGATCATCGCAGGGAATGAAAAAATGTTTGATAAA
TTCAATATCGCGCACAGCCCTTCCCCACAAAATGGCACGATCGTGCATGTAGCTTTTAACCAAAATTATATAGGTTATAT
CGTAATTAGCGATGAGATTAAAGATGACGCTATAGAGTGTTTAAGGGATTTAAAAGCACAAGGGATAGAAAATTTTTGCA
TTTTGAGTGGGGATAGAAAAAGCGTGACAGAAAGCATTGCAAAAACTTTAGGCTGTGAATACCATGCGAGCTTGTTGCCT
GAAGAAAAAACGAGCGTGTTTAAAAACTTTAAAGAGCGCTATAAAGCCCCGGCGATTTTTGTTGGCGATGGCATCAATGA
TGCGCCAACTCTAGCGAGTGCTGATGTGGGGATTGGCATGGGGAAAGGATCAGAATTGAGTAAGCAAAGTGCGGACATTG
TGATCACGAATGATTCTTTAAATTCATTAGTGAAAGTCCTAGCGATCGCTAAAAAAACTAAAAGCATTATTTGGCAAAAT
ATCTTGTTTGCTTTAGGGATTAAGATGGTTTTTATCGTGCTAGGGCTTATGGGGGTAGCGAGCTTGTGGGAAGCCGTTTT
TGGCGATGTGGGGGTTACGCTTTTAGCCTTGGCTAATTCCATGCGCGCGATGAGGGCTTAA

Upstream 100 bases:

>100_bases
TGCGGACTTAAACGCTTGCGAGGGTATAGAAAAATCTCACATGCTTAAAGCGTTGAGTTTTAGAAAGATTTCTTAAAATT
TTTTTAATAAGGGAGAGAAA

Downstream 100 bases:

>100_bases
GAAAGAGCCTTTTTATCGCTAGTGCATTAAGAAGCTTAAAGGGGAAAAATGCATAAAATAGAGCAATTACTCCAAACTCT
AGTGCTGATGGGGTGGAGTT

Product: heavy metal-transporting ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MQEYHIHNLDCPDCAAKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAVEKPLSFTPLIT
TIIVFLGAILILRLNPSAFIEKAVFVVLALVYLISGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIIV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDELVSVTPEDLQINDIVVVKVGEKVPVDGVVIKGESLLDERALS
GESMPINVSENSKVLGGSLNLKAVLEIKVEKIYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
MDIVPQNRHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDNQHQHDIKNYEELSGMGVKAQCHADLIIAGNEKMFDK
FNIAHSPSPQNGTIVHVAFNQNYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSVTESIAKTLGCEYHASLLP
EEKTSVFKNFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKMVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Sequences:

>Translated_686_residues
MQEYHIHNLDCPDCAAKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAVEKPLSFTPLIT
TIIVFLGAILILRLNPSAFIEKAVFVVLALVYLISGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIIV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDELVSVTPEDLQINDIVVVKVGEKVPVDGVVIKGESLLDERALS
GESMPINVSENSKVLGGSLNLKAVLEIKVEKIYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
MDIVPQNRHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDNQHQHDIKNYEELSGMGVKAQCHADLIIAGNEKMFDK
FNIAHSPSPQNGTIVHVAFNQNYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSVTESIAKTLGCEYHASLLP
EEKTSVFKNFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKMVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA
>Mature_686_residues
MQEYHIHNLDCPDCAAKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPHLSLSFKEAVEKPLSFTPLIT
TIIVFLGAILILRLNPSAFIEKAVFVVLALVYLISGKDVILGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIIV
FYSAGEFLQKLAISRSKKSLKALVDVAPNLAYLKKGDELVSVTPEDLQINDIVVVKVGEKVPVDGVVIKGESLLDERALS
GESMPINVSENSKVLGGSLNLKAVLEIKVEKIYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVL
PPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKV
MDIVPQNRHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDNQHQHDIKNYEELSGMGVKAQCHADLIIAGNEKMFDK
FNIAHSPSPQNGTIVHVAFNQNYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRKSVTESIAKTLGCEYHASLLP
EEKTSVFKNFKERYKAPAIFVGDGINDAPTLASADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQN
ILFALGIKMVFIVLGLMGVASLWEAVFGDVGVTLLALANSMRAMRA

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=24.812030075188, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI115529486, Length=697, Percent_Identity=26.8292682926829, Blast_Score=194, Evalue=3e-49,
Organism=Homo sapiens, GI55743073, Length=524, Percent_Identity=27.6717557251908, Blast_Score=176, Evalue=9e-44,
Organism=Escherichia coli, GI1789879, Length=693, Percent_Identity=33.1890331890332, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1786691, Length=505, Percent_Identity=29.3069306930693, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786914, Length=504, Percent_Identity=24.6031746031746, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17556548, Length=575, Percent_Identity=28.1739130434783, Blast_Score=178, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=27.037037037037, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319772, Length=600, Percent_Identity=25.8333333333333, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI221329854, Length=570, Percent_Identity=24.5614035087719, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 75034; Mature: 75034

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEYHIHNLDCPDCAAKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEAVEKPLSFTPLITTIIVFLGAILILRLNPSAFIEKAVFVVLALVYLISGKDVI
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIIVFYSAGEFLQKLAISRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDELVSVTPEDLQINDIVVVKVGEKVPVDGVVIKGESLLDERALS
HHHHHHCCCHHHHHCCCCEEEECCCCEEECCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPINVSENSKVLGGSLNLKAVLEIKVEKIYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCEEEECCCCEEECCCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAVLPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVMDIVPQNRHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDNQHQHDIKNYEELSGMGVKAQCHADLIIAGNEKMFDK
HHHHHCCCHHEEHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECEEEEEECCCHHHHH
FNIAHSPSPQNGTIVHVAFNQNYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK
CCCCCCCCCCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCHH
SVTESIAKTLGCEYHASLLPEEKTSVFKNFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKMVFIVLGLMGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQEYHIHNLDCPDCAAKLERDLNKLDCVKKAQINFSTSKLFLDTSDFEKVKAFIKQNEPH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCCC
LSLSFKEAVEKPLSFTPLITTIIVFLGAILILRLNPSAFIEKAVFVVLALVYLISGKDVI
EEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LGAFRGLRKGQFFDENALMLIATIAAFCVGAYEESVSIIVFYSAGEFLQKLAISRSKKSL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHH
KALVDVAPNLAYLKKGDELVSVTPEDLQINDIVVVKVGEKVPVDGVVIKGESLLDERALS
HHHHHHCCCHHHHHCCCCEEEECCCCEEECCEEEEEECCCCCCCCEEECCHHHHHHHHCC
GESMPINVSENSKVLGGSLNLKAVLEIKVEKIYKDSSIAKVVDLVQQATNEKSETEKFIT
CCCCEEEECCCCEEECCCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHH
KFSRYYTPSVLFIALMIAVLPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHCCCC
GAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVMDIVPQNRHSKEEVLHYASC
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SQLLSTHPIALSIQKACEEMLKDNQHQHDIKNYEELSGMGVKAQCHADLIIAGNEKMFDK
HHHHHCCCHHEEHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECEEEEEECCCHHHHH
FNIAHSPSPQNGTIVHVAFNQNYIGYIVISDEIKDDAIECLRDLKAQGIENFCILSGDRK
CCCCCCCCCCCCEEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCHH
SVTESIAKTLGCEYHASLLPEEKTSVFKNFKERYKAPAIFVGDGINDAPTLASADVGIGM
HHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
GKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKMVFIVLGLMGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLWEAVFGDVGVTLLALANSMRAMRA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]