Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 109947299

GI number: 109947299

Start: 638420

End: 638740

Strand: Direct

Name: trxA [H]

Synonym: Hac_0728

Alternate gene names: 109947299

Gene position: 638420-638740 (Clockwise)

Preceding gene: 109947298

Following gene: 109947300

Centisome position: 41.08

GC content: 37.69

Gene sequence:

>321_bases
ATGAGTCACTATATTGAATTAACTGAAGAAAATTTTGAAAGCACCATTAAAAAAGGGGTTGCGTTAGTGGATTTTTGGGC
ACCATGGTGTGGTCCTTGCAAGATGCTATCCCCTATAATTGATGAATTGGCTAGCGAATATGAAGGTAAGGCTAAGATTT
GTAAAGTCAATACCGACGATCAAGAAGAATTGAGTGCAAAATTTAACATTAGAAGCATTCCTACCCTTTTATTCACAAAA
GATGGTGAAGTCGTCCATCAGCTAGTGGGCGTGCAAACTAAAGTCGCTTTAAAAGAGCAATTAGACAAACTTTTAGGCTA
G

Upstream 100 bases:

>100_bases
ATATCACTTTTTAGACTTATTTAAAATAAAAGACTTTGCATTAACATTCTCAAGCTAGTATTATTATCGTTAATCAAAAT
CACATATTTAGGAGTAACTA

Downstream 100 bases:

>100_bases
TAGCCATGATAGATTGTGCGATCATTGGAGGTGGTCCTGCAGGCTTGAGTGCGGGGCTTTATGCCACTAGAGGCGGTGTC
AAAAACGCCGTTTTGTTTGA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPIIDELASEYEGKAKICKVNTDDQEELSAKFNIRSIPTLLFTK
DGEVVHQLVGVQTKVALKEQLDKLLG

Sequences:

>Translated_106_residues
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPIIDELASEYEGKAKICKVNTDDQEELSAKFNIRSIPTLLFTK
DGEVVHQLVGVQTKVALKEQLDKLLG
>Mature_105_residues
SHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPIIDELASEYEGKAKICKVNTDDQEELSAKFNIRSIPTLLFTKD
GEVVHQLVGVQTKVALKEQLDKLLG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=85, Percent_Identity=38.8235294117647, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI42794771, Length=89, Percent_Identity=39.3258426966292, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI224493972, Length=89, Percent_Identity=39.3258426966292, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI21361657, Length=109, Percent_Identity=34.8623853211009, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=51, Blast_Score=107, Evalue=1e-25,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=43.1372549019608, Blast_Score=94, Evalue=1e-21,
Organism=Escherichia coli, GI87081747, Length=104, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=89, Percent_Identity=35.9550561797753, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980565, Length=83, Percent_Identity=38.5542168674699, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=74, Percent_Identity=37.8378378378378, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=81, Percent_Identity=43.2098765432099, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=102, Percent_Identity=34.3137254901961, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=100, Percent_Identity=33, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=94, Percent_Identity=36.1702127659575, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=34.375, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=36.9047619047619, Blast_Score=68, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=94, Percent_Identity=30.8510638297872, Blast_Score=61, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639826, Length=74, Percent_Identity=40.5405405405405, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=36.734693877551, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=38.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=38.6666666666667, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=69, Percent_Identity=40.5797101449275, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17530795, Length=69, Percent_Identity=36.231884057971, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI18859803, Length=104, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=38.75, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358065, Length=87, Percent_Identity=34.4827586206897, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11913; Mature: 11782

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPIIDELASEYEGKAKICKVNTDD
CCCCHHHHHHHHHHHHHCCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCC
QEELSAKFNIRSIPTLLFTKDGEVVHQLVGVQTKVALKEQLDKLLG
HHHHHHHCCCCCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPIIDELASEYEGKAKICKVNTDD
CCCHHHHHHHHHHHHHCCCHHEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCC
QEELSAKFNIRSIPTLLFTKDGEVVHQLVGVQTKVALKEQLDKLLG
HHHHHHHCCCCCCCEEEEECCHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]