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The map label for this gene is vacA beta fragment 13 [H]

Identifier: 109947098

GI number: 109947098

Start: 439904

End: 440122

Strand: Reverse

Name: vacA beta fragment 13 [H]

Synonym: Hac_0502

Alternate gene names: 109947098

Gene position: 440122-439904 (Counterclockwise)

Preceding gene: 109947099

Following gene: 109947092

Centisome position: 28.32

GC content: 45.21

Gene sequence:

>219_bases
TTGCATGCTGGAGTTTTACAAGAGTTTGCCAACTTTGAATCCAACCACGCTGTGTCTTTGAACGCCTTCAAAGCAAATGC
CGCTCGCAACCCTTTAAACACGCATGCCAGAGTGATGATGGGTGGGGAATTGGATTTGGCTAAAGAAGTGTTTTTGAATT
GGGGCTTCATTGATTTGGACAACTTGATTTCCAATGCGAGCCGTTTCGCTTCCAGTTGA

Upstream 100 bases:

>100_bases
AAAAGCGGCTTTAAGCGATGGTGCAAGCGGTCAGCATTTATCCAACGCTGACGGCAACCTACAAGCCCGCTATTATTGCC
GAGACACTTCATGCTTCTGT

Downstream 100 bases:

>100_bases
GGAATGGGATATAGTTTCTGATCGCTTCTCTAACCCATGCTTGGCATGGGTTTATGGGGGATATTAAAACGAAATCAATA
AAGTCTTAATCTCTTTAGCA

Product: vacuolating cytotoxin fragment 13

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 72; Mature: 72

Protein sequence:

>72_residues
MHAGVLQEFANFESNHAVSLNAFKANAARNPLNTHARVMMGGELDLAKEVFLNWGFIDLDNLISNASRFASS

Sequences:

>Translated_72_residues
MHAGVLQEFANFESNHAVSLNAFKANAARNPLNTHARVMMGGELDLAKEVFLNWGFIDLDNLISNASRFASS
>Mature_72_residues
MHAGVLQEFANFESNHAVSLNAFKANAARNPLNTHARVMMGGELDLAKEVFLNWGFIDLDNLISNASRFASS

Specific function: Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Vacuolating cytotoxin translocator:Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 autotransporter (TC 1.B.12) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005546
- InterPro:   IPR006315
- InterPro:   IPR003842 [H]

Pfam domain/function: PF03797 Autotransporter; PF02691 VacA [H]

EC number: NA

Molecular weight: Translated: 7893; Mature: 7893

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAGVLQEFANFESNHAVSLNAFKANAARNPLNTHARVMMGGELDLAKEVFLNWGFIDLD
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCHH
NLISNASRFASS
HHHHHHHHHCCC
>Mature Secondary Structure
MHAGVLQEFANFESNHAVSLNAFKANAARNPLNTHARVMMGGELDLAKEVFLNWGFIDLD
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCHH
NLISNASRFASS
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7629077 [H]