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The map label for this gene is edd [H]

Identifier: 109947044

GI number: 109947044

Start: 385661

End: 387487

Strand: Direct

Name: edd [H]

Synonym: Hac_0442

Alternate gene names: 109947044

Gene position: 385661-387487 (Clockwise)

Preceding gene: 109947039

Following gene: 109947045

Centisome position: 24.82

GC content: 41.32

Gene sequence:

>1827_bases
ATGCCTAAACATTCTTTAGAACAAATCAAAGAAAAAATTACGGAGCGTAGCAAAAAAACCAGAGAGCTTTATTTAGAAAA
TATCTTTAACCCTAAAAACCAGCCCAAGATTGAGAATTTGGGTTGTGCAAATATCGCGCATGTTACAGCGAGCATGCCAA
AGCATTTAAAAATGCCTTTAGGTTCGCATAAAAGAAAGCATTTTGCGATCATCACGGCTTATAATGACATGCTTTCAGCC
CACCAGCCTTTTAAAGATTACCCTGACTTGATTAAAAAAGAACTGCAAGAGCATAACGCCTATGCGAGCGTCGCTAGTGG
GGTGCCAGCGATGTGTGATGGTATCACGCAAGGTTATGAGGGCATGGAATTGAGCTTGTTTAGTAGAGATGTGATCGCGC
TAAGCACCGTCGTAGGGTTAAGCCATAATGTTTTTGATGGGGCGTTTTTTTTAGGCGTGTGCGATAAAATCGTGCCAGGC
TTACTCATAGGGGCGTTAAGCTTTGGGAATTTAGCGAGCGTGTTTGTGCCAAGCGGGCCTATGGTGAGTGGGATAGAAAA
CTTTAAAAAAGCCAAAGCGCGTCAAGATTTTGCAATGGGAAAGATCAACAGAGAAGAGCTTTTAAAAGTAGAAATGCAAA
GCTACCATGATGTGGGGACTTGCACTTTTTATGGCACGGCTAATTCCAATCAAATGATGATGGAATTTATGGGATTGCAT
GCGGCTAATTCTAGTTTTATCAACCCTAACAACCCCTTACGAAAGGTTTTAGTAGAAGAGAGCGCGAAAAGATTAGCGAG
CGGGAAAGTCCTGCCTTTAGCCAAACTCATTGATGAAAAAAGTATTCTCAACGCTCTTATAGGTTTAATGGCAACAGGGG
GTTCTACTAACCATACTTTACATTTGATCGCTATCGCTAGATCTTGTGGGGTCATTCTCAATTGGGACGATTTTGACGCA
ATCTCTAATCTCATACCCCTTTTAGCTAAAGTCTATCCTAACGGATCAGCCGATGTGAATGCTTTTGAAGCGTGTGGGGG
CTTAGCGTTTGTGATCAAAGAGTTGTTAAAAGAGGGGCTTTTATTTGAAGACACTCATACGATCATGGATACCGAAACGC
AAAAAGGCATGCAAAATTACACCAAAACCCCCTTTTTAGAAAACAATCAATTGGTGTATAAAGATGCCATCAATCATAGC
TTAAATACCGACATCCTACGATCCGTTAGCGAGCCTTTTGCCACTAATGGGGGGCTTAAAATCTTAAAGGGTAATTTGGG
GCGAGCGGTGATTAAAATCTCAGCCATTAAAGATGAACATAGGAAAATTAAGGCTAGAGCGATTGTTTTTAAAACCCAAA
GCGAATTTTTAGAGCGCTTTAAAAATAAAGAATTGGAGAGGGATTTTGTGGCTGTTTTACCTTTCCAAGGGCCGAAGTTT
AATGGCATGCCAGAATTGCACAAACTCACCACGAATTTAGGGGCTTTGCAGGATATGGGCTACAAGGTCGCGCTTGTTAC
AGATGGGCGCATGAGTGGGGCGAGCGGGAAAGTACCTAGCGCGATCCATTTAAGTCCTGAGGGGGCGTTGAATGGGGCGA
TCATTAGGATTAAAGATGGCGATTTAATAGAATTAGACGCTCCTAATAACGCTTTAAATGTGCTTGAAAAGGATTTTGAA
AATAGAGAAATCAACCCCTTGTTTTTAGAAATCTTAAAAGATCTAGAAAAGCCAAGTTTTGGGCTAGGTAGGGAATTATT
TACGAGCTTAAGATTGAATGTCAATACGGCTGAAGAGGGTGCCATGAGTTTTGGCATAAAAATATAA

Upstream 100 bases:

>100_bases
CCAGTCGCGCCAAAAAGAACCAGATCAAAATCTAACATCAATAACCCTTTTAGAGTGTTTTTGAGTTATTATATATTAAA
TCTTAATTGAAGGGGTGTGT

Downstream 100 bases:

>100_bases
AGGATATAAAATGCAAAATAAAATACAAGATAAAGTAATAGAGGTTTTACAAATTAGCCCCATTGTCCCTGTGGTGGTGA
TTGAAGATCTGAAAGACGCT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIENLGCANIAHVTASMPKHLKMPLGSHKRKHFAIITAYNDMLSA
HQPFKDYPDLIKKELQEHNAYASVASGVPAMCDGITQGYEGMELSLFSRDVIALSTVVGLSHNVFDGAFFLGVCDKIVPG
LLIGALSFGNLASVFVPSGPMVSGIENFKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
AANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDA
ISNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTETQKGMQNYTKTPFLENNQLVYKDAINHS
LNTDILRSVSEPFATNGGLKILKGNLGRAVIKISAIKDEHRKIKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKF
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIRIKDGDLIELDAPNNALNVLEKDFE
NREINPLFLEILKDLEKPSFGLGRELFTSLRLNVNTAEEGAMSFGIKI

Sequences:

>Translated_608_residues
MPKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIENLGCANIAHVTASMPKHLKMPLGSHKRKHFAIITAYNDMLSA
HQPFKDYPDLIKKELQEHNAYASVASGVPAMCDGITQGYEGMELSLFSRDVIALSTVVGLSHNVFDGAFFLGVCDKIVPG
LLIGALSFGNLASVFVPSGPMVSGIENFKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
AANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDA
ISNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTETQKGMQNYTKTPFLENNQLVYKDAINHS
LNTDILRSVSEPFATNGGLKILKGNLGRAVIKISAIKDEHRKIKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKF
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIRIKDGDLIELDAPNNALNVLEKDFE
NREINPLFLEILKDLEKPSFGLGRELFTSLRLNVNTAEEGAMSFGIKI
>Mature_607_residues
PKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIENLGCANIAHVTASMPKHLKMPLGSHKRKHFAIITAYNDMLSAH
QPFKDYPDLIKKELQEHNAYASVASGVPAMCDGITQGYEGMELSLFSRDVIALSTVVGLSHNVFDGAFFLGVCDKIVPGL
LIGALSFGNLASVFVPSGPMVSGIENFKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLHA
ANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDAI
SNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTETQKGMQNYTKTPFLENNQLVYKDAINHSL
NTDILRSVSEPFATNGGLKILKGNLGRAVIKISAIKDEHRKIKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKFN
GMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIRIKDGDLIELDAPNNALNVLEKDFEN
REINPLFLEILKDLEKPSFGLGRELFTSLRLNVNTAEEGAMSFGIKI

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=604, Percent_Identity=49.8344370860927, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI48994964, Length=533, Percent_Identity=27.2045028142589, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI2367371, Length=457, Percent_Identity=29.3216630196937, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786464, Length=467, Percent_Identity=26.5524625267666, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322476, Length=473, Percent_Identity=31.7124735729387, Blast_Score=174, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 66901; Mature: 66770

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIENLGCANIAHVTASMPKHLKMPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHCCCC
GSHKRKHFAIITAYNDMLSAHQPFKDYPDLIKKELQEHNAYASVASGVPAMCDGITQGYE
CCCCCCEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCC
GMELSLFSRDVIALSTVVGLSHNVFDGAFFLGVCDKIVPGLLIGALSFGNLASVFVPSGP
CCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
MVSGIENFKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
AANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
HLIAIARSCGVILNWDDFDAISNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGL
EEEEEHHHCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHHCCC
LFEDTHTIMDTETQKGMQNYTKTPFLENNQLVYKDAINHSLNTDILRSVSEPFATNGGLK
EEECCHHHHCCHHHHHHHHHCCCCCCCCCCEEEHHHHCCCCCHHHHHHHHCCCCCCCCCE
ILKGNLGRAVIKISAIKDEHRKIKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKF
EEECCCCEEEEEEEEHHHHHHHEEEHEEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCC
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIRIKDG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEEECC
DLIELDAPNNALNVLEKDFENREINPLFLEILKDLEKPSFGLGRELFTSLRLNVNTAEEG
CEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCC
AMSFGIKI
CCCCCCCC
>Mature Secondary Structure 
PKHSLEQIKEKITERSKKTRELYLENIFNPKNQPKIENLGCANIAHVTASMPKHLKMPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHCCCC
GSHKRKHFAIITAYNDMLSAHQPFKDYPDLIKKELQEHNAYASVASGVPAMCDGITQGYE
CCCCCCEEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCC
GMELSLFSRDVIALSTVVGLSHNVFDGAFFLGVCDKIVPGLLIGALSFGNLASVFVPSGP
CCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
MVSGIENFKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLH
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
AANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTL
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
HLIAIARSCGVILNWDDFDAISNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGL
EEEEEHHHCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHHCCC
LFEDTHTIMDTETQKGMQNYTKTPFLENNQLVYKDAINHSLNTDILRSVSEPFATNGGLK
EEECCHHHHCCHHHHHHHHHCCCCCCCCCCEEEHHHHCCCCCHHHHHHHHCCCCCCCCCE
ILKGNLGRAVIKISAIKDEHRKIKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKF
EEECCCCEEEEEEEEHHHHHHHEEEHEEEEECHHHHHHHHHCCCCCCCEEEEECCCCCCC
NGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIRIKDG
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEEECC
DLIELDAPNNALNVLEKDFENREINPLFLEILKDLEKPSFGLGRELFTSLRLNVNTAEEG
CEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCC
AMSFGIKI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]