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The map label for this gene is adhA [H]

Identifier: 109947040

GI number: 109947040

Start: 381271

End: 382323

Strand: Reverse

Name: adhA [H]

Synonym: Hac_0437

Alternate gene names: 109947040

Gene position: 382323-381271 (Counterclockwise)

Preceding gene: 109947041

Following gene: 109947038

Centisome position: 24.6

GC content: 40.36

Gene sequence:

>1053_bases
ATGAGAGTCCAATCTAAAGGTTTTGCTATTTTTTCTAAAGACGGGCATTTCAAACCCCATGATTTTAGCCGCCATGCTAT
AGGCCCTCAAGATGTGTTGATTGACATTCATTATGCAGGGATTTGTCATAGCGATATTCATAGCGCTTATAGCGAATGGA
AAGAAGGCATCTACCCTATGATTCCTGGGCATGAAATTGCTGGGGTCATCAAAGAAGTGGGTAAGGAAGTTAAGAAATTT
AAAGTGGGTGATGTGGTGGGAGTGGGCTGTTTTGTCAATTCATGCAAAACTTGTAAGCCATGTAAAGAACACCAAGAGCA
ATTTTGTGCTAACCACAAAACGGTATTCACTTATGATTGTTTGGATTATTTCCATGACAATGAACCCCACATGGGCGGAT
ACTCTAATAACATTGTGGTAGATGAAAATTATGTGATTAGCGTGGATAAAAACGCTCCTTTAGAAAAAGTAGCCCCCTTG
CTTTGTGCGGGCATCACCACTTATTCGCCCTTAAAATTTTCTAAGGTTACTAAAGGCACAAAAGTCGGCGTCGCTGGGTT
TGGTGGGCTAGGAAGCATGGCGGTTAAATACGCTGTGGTCATGGGGGCTGAAGTGAGCGTTTTTGCAAGAAACGAACACA
AAAAACAAGACGCTTTAAGCATGGGGGCTAAACATTTCTACACTGACCCTAAAAATTGTAAAGAAGAATTGGATTTTATC
ATTTCAACCATTCCCACCCACTATGATTTAAAGGACTATCTCAAGCTCTTAACTTATAACGGCGATCTAGCCCTTGTGGG
ACTCCCCCCTATAGAAGTGGCTCCAACGCTTAATGTTTTTGATTTTATCAGTTTGGGTAATCGCAAGGTTTATGGCTCAT
TGATTGGGGGCATTAAAGAAACCCAAGAGATGATGGATTTCTCCATTAAACACAATATTTACCCTGAAATAGATTTGATT
TTAGGCAAGGATATTGATACGGCTTACCATAACCTAACCCATGGGAAAGCAAAATTCCGCTATGTGATTGATATGAAAAA
ATCGTTTGACTAA

Upstream 100 bases:

>100_bases
ACCATATAACCAATAATTGTAAAAATAGTTAAATCCATAAAAATACAAGCAAACCATAAAAACGATACAATAACGGTATT
TTATGAAATAAGGAGTTTTT

Downstream 100 bases:

>100_bases
AGACTTTTAACTCTAGCTCTTTTTTAAGAGCTTGATTAAGATTTTTTTTACAATCCCATGAAGTCCTAGAACTTTAAGGA
TCTTACTGACCACCTTTTTA

Product: NADP-dependent alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRVQSKGFAIFSKDGHFKPHDFSRHAIGPQDVLIDIHYAGICHSDIHSAYSEWKEGIYPMIPGHEIAGVIKEVGKEVKKF
KVGDVVGVGCFVNSCKTCKPCKEHQEQFCANHKTVFTYDCLDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPL
LCAGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVVMGAEVSVFARNEHKKQDALSMGAKHFYTDPKNCKEELDFI
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPIEVAPTLNVFDFISLGNRKVYGSLIGGIKETQEMMDFSIKHNIYPEIDLI
LGKDIDTAYHNLTHGKAKFRYVIDMKKSFD

Sequences:

>Translated_350_residues
MRVQSKGFAIFSKDGHFKPHDFSRHAIGPQDVLIDIHYAGICHSDIHSAYSEWKEGIYPMIPGHEIAGVIKEVGKEVKKF
KVGDVVGVGCFVNSCKTCKPCKEHQEQFCANHKTVFTYDCLDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPL
LCAGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVVMGAEVSVFARNEHKKQDALSMGAKHFYTDPKNCKEELDFI
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPIEVAPTLNVFDFISLGNRKVYGSLIGGIKETQEMMDFSIKHNIYPEIDLI
LGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
>Mature_350_residues
MRVQSKGFAIFSKDGHFKPHDFSRHAIGPQDVLIDIHYAGICHSDIHSAYSEWKEGIYPMIPGHEIAGVIKEVGKEVKKF
KVGDVVGVGCFVNSCKTCKPCKEHQEQFCANHKTVFTYDCLDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPL
LCAGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVVMGAEVSVFARNEHKKQDALSMGAKHFYTDPKNCKEELDFI
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPIEVAPTLNVFDFISLGNRKVYGSLIGGIKETQEMMDFSIKHNIYPEIDLI
LGKDIDTAYHNLTHGKAKFRYVIDMKKSFD

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=320, Percent_Identity=27.8125, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI34577061, Length=318, Percent_Identity=27.0440251572327, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=26.775956284153, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=27.0491803278689, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501929, Length=318, Percent_Identity=26.1006289308176, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=331, Percent_Identity=23.8670694864048, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71743840, Length=331, Percent_Identity=23.8670694864048, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71565154, Length=211, Percent_Identity=29.8578199052133, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786518, Length=354, Percent_Identity=41.2429378531073, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082401, Length=347, Percent_Identity=31.9884726224784, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI87081918, Length=350, Percent_Identity=27.1428571428571, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790045, Length=281, Percent_Identity=27.0462633451957, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788075, Length=286, Percent_Identity=27.6223776223776, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788073, Length=281, Percent_Identity=24.9110320284698, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=319, Percent_Identity=28.2131661442006, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=28.5714285714286, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=326, Percent_Identity=26.9938650306748, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=206, Percent_Identity=33.0097087378641, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=191, Percent_Identity=32.9842931937173, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=190, Percent_Identity=33.1578947368421, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=203, Percent_Identity=30.5418719211823, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=183, Percent_Identity=30.0546448087432, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=367, Percent_Identity=28.6103542234332, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319621, Length=356, Percent_Identity=27.8089887640449, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=354, Percent_Identity=27.683615819209, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319949, Length=346, Percent_Identity=30.0578034682081, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324486, Length=354, Percent_Identity=27.683615819209, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323980, Length=342, Percent_Identity=29.8245614035088, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320033, Length=303, Percent_Identity=27.7227722772277, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=387, Percent_Identity=25.5813953488372, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=330, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=203, Percent_Identity=28.0788177339901, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 39002; Mature: 39002

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVQSKGFAIFSKDGHFKPHDFSRHAIGPQDVLIDIHYAGICHSDIHSAYSEWKEGIYPM
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
IPGHEIAGVIKEVGKEVKKFKVGDVVGVGCFVNSCKTCKPCKEHQEQFCANHKTVFTYDC
CCCHHHHHHHHHHHHHHHHEECCCEEEEHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEHH
LDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLKFSKVTKGT
HHHHCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCC
KVGVAGFGGLGSMAVKYAVVMGAEVSVFARNEHKKQDALSMGAKHFYTDPKNCKEELDFI
EECEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHCCCHHHHHHHHHHH
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPIEVAPTLNVFDFISLGNRKVYGSLIGGIKE
HHHCCCCCCHHHHHHHHEECCCEEEEECCCCCCCCCCCHHHHHHCCCCEEHHHHHCCHHH
TQEMMDFSIKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MRVQSKGFAIFSKDGHFKPHDFSRHAIGPQDVLIDIHYAGICHSDIHSAYSEWKEGIYPM
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
IPGHEIAGVIKEVGKEVKKFKVGDVVGVGCFVNSCKTCKPCKEHQEQFCANHKTVFTYDC
CCCHHHHHHHHHHHHHHHHEECCCEEEEHHHHHCCCCCCHHHHHHHHHHCCCCEEEEEHH
LDYFHDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLKFSKVTKGT
HHHHCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCC
KVGVAGFGGLGSMAVKYAVVMGAEVSVFARNEHKKQDALSMGAKHFYTDPKNCKEELDFI
EECEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCHHHCCCHHHHHHHHHHH
ISTIPTHYDLKDYLKLLTYNGDLALVGLPPIEVAPTLNVFDFISLGNRKVYGSLIGGIKE
HHHCCCCCCHHHHHHHHEECCCEEEEECCCCCCCCCCCHHHHHHCCCCEEHHHHHCCHHH
TQEMMDFSIKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]