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The map label for this gene is cah [H]

Identifier: 109946999

GI number: 109946999

Start: 335560

End: 336303

Strand: Reverse

Name: cah [H]

Synonym: Hac_0392

Alternate gene names: 109946999

Gene position: 336303-335560 (Counterclockwise)

Preceding gene: 109947003

Following gene: 109946998

Centisome position: 21.64

GC content: 40.59

Gene sequence:

>744_bases
ATGAAAAAAACTTTTTTGATCGCTCTAGCACTTGCAACTTCTCTTATAGGTGCTGAAAAAACCCATTGGGATTACAAAAA
CAAAGAAAATGGCCCACACCATTGGGACAAATTGCATAAAGATTTTGAAATGTGCAAAAGCGGTAAGAGCCAGTCTCCTA
TCAATATTGAGCATTATTACCACACGCAAGATAAAGCCGATTTGCAATTCAAATACGCCGCTTCCAAACCTAAAGCGGTA
TCTTTCACCCACCACACTTTAAAGGCTTCGTTTGAGCCGACTAATCATATCAATTATAGAGGGCATGACTATGTGTTGGA
TAATGTGCATTTCCACGCCCCTATGGAGTTTTTAATCAATGGTAAAAATAAGCCTTTGAGTGCGCATTTCGTGCATAAAG
ACGCTAAAGGGCGTTTGTTAGTGTTAGCGATTGGCTTTGAAGAAGGGAAAGAAAACCCAAACCTTAACCCTATTTTAGAA
GGCATTCAAAAGAAACAGGATTTTAAGGCGGTAGTTTTAGACGCTTTCTTGCCTAAAACAATCAATTACTACCATTTTAA
CGGCTCTTTGACCGCTCCGCCTTGCACAGAAGGGGTGGCATGGTTTGTGATAGAAGAGCCTTTGGAAATCTCTGCCAAGC
AATTAGCTGAAATCAAAAAACGCATGAAAAATTCGCCTAACCAACGCCCCGTCCAGCCTGACTACAACACCGTAATCATT
AAAAGTTCAACTGAAACCCGCTAA

Upstream 100 bases:

>100_bases
GGGGCTTATCCTTAAGCTCATTTTTGACAGCCCCATCCGTTATGGTTTGAGCGCTAGAATTGAGTCGTTGTTTAAAAAAT
TTAAAATAAAGGATAACGAA

Downstream 100 bases:

>100_bases
AATTTAAAACTCTCTCTTTTTAAAGAGAGAGACATCAAAATCATTTTTTGTAAAACAACGCTAAAAATTGTAACCGCCTA
GTATTTTGTAAAGCGCTTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKKTFLIALALATSLIGAEKTHWDYKNKENGPHHWDKLHKDFEMCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAV
SFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINGKNKPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLNPILE
GIQKKQDFKAVVLDAFLPKTINYYHFNGSLTAPPCTEGVAWFVIEEPLEISAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSTETR

Sequences:

>Translated_247_residues
MKKTFLIALALATSLIGAEKTHWDYKNKENGPHHWDKLHKDFEMCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAV
SFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINGKNKPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLNPILE
GIQKKQDFKAVVLDAFLPKTINYYHFNGSLTAPPCTEGVAWFVIEEPLEISAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSTETR
>Mature_247_residues
MKKTFLIALALATSLIGAEKTHWDYKNKENGPHHWDKLHKDFEMCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAV
SFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINGKNKPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLNPILE
GIQKKQDFKAVVLDAFLPKTINYYHFNGSLTAPPCTEGVAWFVIEEPLEISAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSTETR

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4885101, Length=260, Percent_Identity=26.5384615384615, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI38348436, Length=254, Percent_Identity=28.3464566929134, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4557395, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI258679498, Length=252, Percent_Identity=24.2063492063492, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI192447434, Length=252, Percent_Identity=24.2063492063492, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI192447432, Length=252, Percent_Identity=24.2063492063492, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI192447430, Length=252, Percent_Identity=24.2063492063492, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4502517, Length=252, Percent_Identity=24.2063492063492, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22027500, Length=241, Percent_Identity=26.1410788381743, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI130979954, Length=287, Percent_Identity=21.9512195121951, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI130979679, Length=287, Percent_Identity=21.9512195121951, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI9910366, Length=287, Percent_Identity=21.9512195121951, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI4885099, Length=263, Percent_Identity=24.7148288973384, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62240989, Length=172, Percent_Identity=28.4883720930233, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI91208428, Length=236, Percent_Identity=30.5084745762712, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24645604, Length=272, Percent_Identity=24.6323529411765, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358169, Length=287, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221329761, Length=272, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 28232; Mature: 28232

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTFLIALALATSLIGAEKTHWDYKNKENGPHHWDKLHKDFEMCKSGKSQSPINIEHYY
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
HTQDKADLQFKYAASKPKAVSFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
ECCCCCCEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEECCEEECCCEEEEEC
GKNKPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLNPILEGIQKKQDFKAVVLDAFLPKT
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
INYYHFNGSLTAPPCTEGVAWFVIEEPLEISAKQLAEIKKRMKNSPNQRPVQPDYNTVII
CEEEEECCEECCCCCCCCEEEEEECCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
KSSTETR
ECCCCCC
>Mature Secondary Structure
MKKTFLIALALATSLIGAEKTHWDYKNKENGPHHWDKLHKDFEMCKSGKSQSPINIEHYY
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
HTQDKADLQFKYAASKPKAVSFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
ECCCCCCEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEECCEEECCCEEEEEC
GKNKPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLNPILEGIQKKQDFKAVVLDAFLPKT
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
INYYHFNGSLTAPPCTEGVAWFVIEEPLEISAKQLAEIKKRMKNSPNQRPVQPDYNTVII
CEEEEECCEECCCCCCCCEEEEEECCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
KSSTETR
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]