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The map label for this gene is lpxD [H]

Identifier: 109946989

GI number: 109946989

Start: 327354

End: 328364

Strand: Direct

Name: lpxD [H]

Synonym: Hac_0381

Alternate gene names: 109946989

Gene position: 327354-328364 (Clockwise)

Preceding gene: 109946988

Following gene: 109946990

Centisome position: 21.07

GC content: 40.55

Gene sequence:

>1011_bases
ATGAAATTAAGCGAATTGTTAAACACCTACTCTATTGAAACAGAATTTTCGAACGATTTTGAAGTGCATGCTTTAGCGGA
ATTGGATAAAGCAACGCCTAATGATATTAGCTATATTGATCAAGCGCGTTACCTTAAATTTTTAAAGGATTCAAAAGCTG
GGGCGGTGTTTATCCGTAAAAAAGAATCTTCTAAAGTGCCTAAACACATGCAAGCTTTAGTCGTGGATAACCCCCATTTG
GCTTTCGCTAAAGTCTCGCATGCCTTTAAAGTCCCTTTTTTTAAAAACCCAGAAAGCGTTAGCGAGCCTAAACATTTTGA
AAAAGTAACTATCATGCCAAATGTTACGATTGGAGAGAGCGTAGAAATTGGCGAAAACTCTTTGATTTATCCGGGCGTGG
TGATCGCTGATGGGGTCAAAATCGGTAAAAATTGCGTTTTATATCCTCGGGTCATTTTGTATCAAAACACGATTTTAGAA
GATAATGTCATTATCCATGCAGGCAGTGTGATTGGGGGCGATGGCTTTGGTTATGCACACACCGCTTTAGGAGAGCATGT
CAAAATTGAGCATGTGGGGATTGTTAGGATTCAAAAAAATGTAGAAATTGGAGTTAACACGGCGATTGATAGGGCGGTGT
TTGGGGAGACTTTGATTAAAGAGGGCGTTAAGATTGATAACTTGGTTCAAATTGGGCATAATTGTGTTTTGGGTGAACAT
AGCATTGTCGTTTCTCAAGTGGGTTTGAGTGGCTCTACGACCACAGGTCGTAATGTGGTTTTTGGCGGGCAAGTGGGCAT
TGGGGGGCATTTGCATGTGGGCGAATTCACTCAAATTGGAGGCAAAAGCGCGGTGGGTAAAGATTTGCCCCCTAACACTA
ATTTTGCCGGAGCAATCCCTGCTATGGAAATCCATGAATGGCACCATTTCTTAGCTCATTTAAGAACGAATTTTAGAAAA
CAGCAAAAAACGAGTTTGTTGCAAAAAGCTAAAGGGTTTTTTAAGTCTTAA

Upstream 100 bases:

>100_bases
GATGCTGGCTATCATGTAATGGGCATGGGAGCTGTGGAAGAAAAAGATAATAAAGCTGTATTATCATGGGATTTGCATAA
AGAAGGATAAAGGGGTATTG

Downstream 100 bases:

>100_bases
AGAATGAAATAAGCTATAATAAGCCCATTTTGAATACAAACTTTATCACAAGGACAATCAATGAAAGATAGTTTTCTTTT
TACTTCAGAATCAGTAACCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKLSELLNTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKFLKDSKAGAVFIRKKESSKVPKHMQALVVDNPHL
AFAKVSHAFKVPFFKNPESVSEPKHFEKVTIMPNVTIGESVEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILE
DNVIIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGVNTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS

Sequences:

>Translated_336_residues
MKLSELLNTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKFLKDSKAGAVFIRKKESSKVPKHMQALVVDNPHL
AFAKVSHAFKVPFFKNPESVSEPKHFEKVTIMPNVTIGESVEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILE
DNVIIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGVNTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS
>Mature_336_residues
MKLSELLNTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKFLKDSKAGAVFIRKKESSKVPKHMQALVVDNPHL
AFAKVSHAFKVPFFKNPESVSEPKHFEKVTIMPNVTIGESVEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILE
DNVIIHAGSVIGGDGFGYAHTALGEHVKIEHVGIVRIQKNVEIGVNTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIPAMEIHEWHHFLAHLRTNFRK
QQKTSLLQKAKGFFKS

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=319, Percent_Identity=30.4075235109718, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36722; Mature: 36722

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSELLNTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKFLKDSKAGAVFIRK
CCHHHHHHHEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
KESSKVPKHMQALVVDNPHLAFAKVSHAFKVPFFKNPESVSEPKHFEKVTIMPNVTIGES
CCCCCCCHHHEEEEECCCCEEEEEHHHEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCC
VEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILEDNVIIHAGSVIGGDGFGYAH
EECCCCCEECCCEEEECCEEECCCEEECCEEEEEECEEECCCEEEEECCEECCCCCCHHH
TALGEHVKIEHVGIVRIQKNVEIGVNTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
HHCCCCEEEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIP
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCCCCC
AMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLSELLNTYSIETEFSNDFEVHALAELDKATPNDISYIDQARYLKFLKDSKAGAVFIRK
CCHHHHHHHEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEE
KESSKVPKHMQALVVDNPHLAFAKVSHAFKVPFFKNPESVSEPKHFEKVTIMPNVTIGES
CCCCCCCHHHEEEEECCCCEEEEEHHHEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCC
VEIGENSLIYPGVVIADGVKIGKNCVLYPRVILYQNTILEDNVIIHAGSVIGGDGFGYAH
EECCCCCEECCCEEEECCEEECCCEEECCEEEEEECEEECCCEEEEECCEECCCCCCHHH
TALGEHVKIEHVGIVRIQKNVEIGVNTAIDRAVFGETLIKEGVKIDNLVQIGHNCVLGEH
HHCCCCEEEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
SIVVSQVGLSGSTTTGRNVVFGGQVGIGGHLHVGEFTQIGGKSAVGKDLPPNTNFAGAIP
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCCHHHCCCCCCCCCCCCCCCCCCCCCC
AMEIHEWHHFLAHLRTNFRKQQKTSLLQKAKGFFKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA