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The map label for this gene is hssS [H]

Identifier: 109946956

GI number: 109946956

Start: 293889

End: 295163

Strand: Reverse

Name: hssS [H]

Synonym: Hac_0346

Alternate gene names: 109946956

Gene position: 295163-293889 (Counterclockwise)

Preceding gene: 109946957

Following gene: 109946955

Centisome position: 18.99

GC content: 36.94

Gene sequence:

>1275_bases
TTGCGTTTTTCTATCTTTTTTAAAGTTTTCGTTTTGTTTACGATAACGCTCTTTAGTTTTGGGGCGTTCGCTTACTATTT
CGTGTCTTCTCAAATCAATCACGAAAAGTATCAAAATGAAATGCGCCACTATCAATTTGTGACCACGATTAATGAAATTT
TAAACAAATACTCTGATTATGACGCCGTAGAAGCTTACCTCTATAAAATTGGTTTTAGGGAAACCACGATAGAAAATTTA
GAAAAAATTCTAGTCAAAAGACGCCACCAGTTGCACCATAGAGATATGGGGTATGCGGAAGTGTTTAAATTCAGCGACAT
GATTTTTATCCTTTTGAAAAAGAAAGAGCGTTTTGTGCTTTATAAGGATTTACACTCCATTTCTTATAGGAATTATTTCT
TTGCGATTACGGTAGGCTTGTTGTTGATTTTATCGCTCTTTTTACTTGTTTTGCAGAGTTTATTGCCTTTAAGAGAGTTA
AGGACTCAAGTCAATCGCTTCGCTCAAGGGGATAAAAGCGTGAGTTGCAAGAGCAAGCAAAAAGATGAAATAGGGGATCT
AGCTAACGAATTTGATCATTGCATCCAAAAAATCAACGCGTTGGATGAATCACGGATCTTATTCTTGCGCTCCATCATGC
ATGAATTGCGCACCCCTATCACAAAAGGCAGGCTCTTAAGCGAAATGCTCAAAGAAGAACTGCCTCAAAAGCGCTTCATT
TCTATTTTTGAACGCTTGAACATGCTGATTGAGCAATTTGCCCGCATTGAGCAGCTCGCTTCAAAAAATTATAGGCACAG
TAAGGAAAAATTTTTAATCAGCGATTTGATTGATAAGATTGAAAAAATGCTTTTGATTGATATGGATAAAGAAAGCCCTA
TCCATGTGCCCTCTTCAAATCATATCATTGAAGCGGATTTTGACTTGTTTTCCATAGCGTTAAAAAACATGATAGACAAT
GCGATCAAATACAGCGATGACAAACAAGTGTTTTTGGACTTCATCGGCAATGATTTGGTGATCTCAAACAAAGGCGAGCC
TTTAAAAGAAGATTTTGAAAAGTATTTGCAACCTTATTTTAAATCTCCTAACCCAAGCCAAGCCCATGGCTTTGGGTTAG
GCATGTATATCATTAAAAATGCTTTAGAGACTATGGGGTTGGATTTGAGCTACCATTATAGCGAGGGGAAAAATTGTTTC
ACTATCCATGATTGCGTTTTGAATTATTGCGATTTAAAAAATGGCGAAGAGCTACCCCCCCCTCCGAAAATTTGA

Upstream 100 bases:

>100_bases
CCAAAATTGAAAAAAACCCCAAACAGCCAGAGCATATCATTTCGGTTAGGGGGATTGGCTATAAATTAGAATATTGATTC
TAATAAGGAGCTAAAGGATT

Downstream 100 bases:

>100_bases
AAGAAATAAAAGAGATGAAAGAGACAAAAAAGACCGATTGCAAAGCTAAAGAAAGCCAATGTATAGAGGGAAAACATGTT
CAAACGATTGAGAAGACTAC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MRFSIFFKVFVLFTITLFSFGAFAYYFVSSQINHEKYQNEMRHYQFVTTINEILNKYSDYDAVEAYLYKIGFRETTIENL
EKILVKRRHQLHHRDMGYAEVFKFSDMIFILLKKKERFVLYKDLHSISYRNYFFAITVGLLLILSLFLLVLQSLLPLREL
RTQVNRFAQGDKSVSCKSKQKDEIGDLANEFDHCIQKINALDESRILFLRSIMHELRTPITKGRLLSEMLKEELPQKRFI
SIFERLNMLIEQFARIEQLASKNYRHSKEKFLISDLIDKIEKMLLIDMDKESPIHVPSSNHIIEADFDLFSIALKNMIDN
AIKYSDDKQVFLDFIGNDLVISNKGEPLKEDFEKYLQPYFKSPNPSQAHGFGLGMYIIKNALETMGLDLSYHYSEGKNCF
TIHDCVLNYCDLKNGEELPPPPKI

Sequences:

>Translated_424_residues
MRFSIFFKVFVLFTITLFSFGAFAYYFVSSQINHEKYQNEMRHYQFVTTINEILNKYSDYDAVEAYLYKIGFRETTIENL
EKILVKRRHQLHHRDMGYAEVFKFSDMIFILLKKKERFVLYKDLHSISYRNYFFAITVGLLLILSLFLLVLQSLLPLREL
RTQVNRFAQGDKSVSCKSKQKDEIGDLANEFDHCIQKINALDESRILFLRSIMHELRTPITKGRLLSEMLKEELPQKRFI
SIFERLNMLIEQFARIEQLASKNYRHSKEKFLISDLIDKIEKMLLIDMDKESPIHVPSSNHIIEADFDLFSIALKNMIDN
AIKYSDDKQVFLDFIGNDLVISNKGEPLKEDFEKYLQPYFKSPNPSQAHGFGLGMYIIKNALETMGLDLSYHYSEGKNCF
TIHDCVLNYCDLKNGEELPPPPKI
>Mature_424_residues
MRFSIFFKVFVLFTITLFSFGAFAYYFVSSQINHEKYQNEMRHYQFVTTINEILNKYSDYDAVEAYLYKIGFRETTIENL
EKILVKRRHQLHHRDMGYAEVFKFSDMIFILLKKKERFVLYKDLHSISYRNYFFAITVGLLLILSLFLLVLQSLLPLREL
RTQVNRFAQGDKSVSCKSKQKDEIGDLANEFDHCIQKINALDESRILFLRSIMHELRTPITKGRLLSEMLKEELPQKRFI
SIFERLNMLIEQFARIEQLASKNYRHSKEKFLISDLIDKIEKMLLIDMDKESPIHVPSSNHIIEADFDLFSIALKNMIDN
AIKYSDDKQVFLDFIGNDLVISNKGEPLKEDFEKYLQPYFKSPNPSQAHGFGLGMYIIKNALETMGLDLSYHYSEGKNCF
TIHDCVLNYCDLKNGEELPPPPKI

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49894; Mature: 49894

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSIFFKVFVLFTITLFSFGAFAYYFVSSQINHEKYQNEMRHYQFVTTINEILNKYSDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DAVEAYLYKIGFRETTIENLEKILVKRRHQLHHRDMGYAEVFKFSDMIFILLKKKERFVL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCHHHH
YKDLHSISYRNYFFAITVGLLLILSLFLLVLQSLLPLRELRTQVNRFAQGDKSVSCKSKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KDEIGDLANEFDHCIQKINALDESRILFLRSIMHELRTPITKGRLLSEMLKEELPQKRFI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
SIFERLNMLIEQFARIEQLASKNYRHSKEKFLISDLIDKIEKMLLIDMDKESPIHVPSSN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HIIEADFDLFSIALKNMIDNAIKYSDDKQVFLDFIGNDLVISNKGEPLKEDFEKYLQPYF
CEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHC
KSPNPSQAHGFGLGMYIIKNALETMGLDLSYHYSEGKNCFTIHDCVLNYCDLKNGEELPP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHCCCCCCCCCC
PPKI
CCCC
>Mature Secondary Structure
MRFSIFFKVFVLFTITLFSFGAFAYYFVSSQINHEKYQNEMRHYQFVTTINEILNKYSDY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DAVEAYLYKIGFRETTIENLEKILVKRRHQLHHRDMGYAEVFKFSDMIFILLKKKERFVL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCHHHH
YKDLHSISYRNYFFAITVGLLLILSLFLLVLQSLLPLRELRTQVNRFAQGDKSVSCKSKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
KDEIGDLANEFDHCIQKINALDESRILFLRSIMHELRTPITKGRLLSEMLKEELPQKRFI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
SIFERLNMLIEQFARIEQLASKNYRHSKEKFLISDLIDKIEKMLLIDMDKESPIHVPSSN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HIIEADFDLFSIALKNMIDNAIKYSDDKQVFLDFIGNDLVISNKGEPLKEDFEKYLQPYF
CEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHC
KSPNPSQAHGFGLGMYIIKNALETMGLDLSYHYSEGKNCFTIHDCVLNYCDLKNGEELPP
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHHHCCCCCCCCCC
PPKI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA