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The map label for this gene is kdsB

Identifier: 109946920

GI number: 109946920

Start: 260839

End: 261570

Strand: Reverse

Name: kdsB

Synonym: Hac_0307

Alternate gene names: 109946920

Gene position: 261570-260839 (Counterclockwise)

Preceding gene: 109946925

Following gene: 109946900

Centisome position: 16.83

GC content: 38.39

Gene sequence:

>732_bases
ATGATTATCATCCCTGCTAGATTAAAATCCAGCCGTTTTGAAAATAAAGTGCTAGAATGTATTTTTGGCTTGCCTATGGT
GGTCCGTTGCGCTAAAAATGCGAGTTTAGTTGATGAATGCGTAGTCGCTTGCGATGATGAAAGCATTATGGAAGTGTGTC
AAAAATTCCATATTAAAGCGGTGATGACCTCCAAACACCATAATAGCGGCACGGAGCGCTGTTTGGAAGCGGCTCAACTC
TTAGGATTAAAAAACGATGAAAGGGTTTTAAACTTGCAAGGCGATGAGCCTTTTTTAGAAAAAGAAGTCATTGCAATGTT
ATTAGAAGCCACTAAAAACGCTCCTTTCATGGCGACCTGCGCTAAAGTCATTGATAAAGAAAAAGCCAAAAACCCTAATT
TAGTCAAGGTGGTTTTAGACCATCAAAATAACGCCTTGTATTTTTCACGCTCCCTTATCCCCTTTTTACGAGATTTTGAT
TTGAAACGCCCCACGCCTCTTTTAGGGCATATTGGCATTTATGGTTTTCATAATAGAGAGATCTTAGAAGAATTATGCTC
CTTAAAGCCATGCGTTTTAGAAGAGATAGAAAAGTTAGAGCAATTGAGGGCTTTGTATTATCAAAAAAATATTCTAGTGA
AAATCGTTCAAAGTGAAAGCGTGGGTATTGACACGAAAGAAGATTTGCAAAACGCTTTGAAAATTTTTAACTCTCTGCCA
ACAACGCCGTGA

Upstream 100 bases:

>100_bases
TTAAAAACTCCTAAAGTTCATTAGCCTAAATCTCAAAAGAAATAAGCTTCTTAAATGGGTATAATACCATAAAAATCCCC
TATTTTATAAGGCTTAAAAG

Downstream 100 bases:

>100_bases
TTTTACTTGACTTTTTATAAAAAACACACTAGAATTTCTTTTTTCAAGCGAAATTCCAGATTAGCTCAGCGGTAGAGTAG
GCGGCTGTTAACCGCTTGGT

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIIIPARLKSSRFENKVLECIFGLPMVVRCAKNASLVDECVVACDDESIMEVCQKFHIKAVMTSKHHNSGTERCLEAAQL
LGLKNDERVLNLQGDEPFLEKEVIAMLLEATKNAPFMATCAKVIDKEKAKNPNLVKVVLDHQNNALYFSRSLIPFLRDFD
LKRPTPLLGHIGIYGFHNREILEELCSLKPCVLEEIEKLEQLRALYYQKNILVKIVQSESVGIDTKEDLQNALKIFNSLP
TTP

Sequences:

>Translated_243_residues
MIIIPARLKSSRFENKVLECIFGLPMVVRCAKNASLVDECVVACDDESIMEVCQKFHIKAVMTSKHHNSGTERCLEAAQL
LGLKNDERVLNLQGDEPFLEKEVIAMLLEATKNAPFMATCAKVIDKEKAKNPNLVKVVLDHQNNALYFSRSLIPFLRDFD
LKRPTPLLGHIGIYGFHNREILEELCSLKPCVLEEIEKLEQLRALYYQKNILVKIVQSESVGIDTKEDLQNALKIFNSLP
TTP
>Mature_243_residues
MIIIPARLKSSRFENKVLECIFGLPMVVRCAKNASLVDECVVACDDESIMEVCQKFHIKAVMTSKHHNSGTERCLEAAQL
LGLKNDERVLNLQGDEPFLEKEVIAMLLEATKNAPFMATCAKVIDKEKAKNPNLVKVVLDHQNNALYFSRSLIPFLRDFD
LKRPTPLLGHIGIYGFHNREILEELCSLKPCVLEEIEKLEQLRALYYQKNILVKIVQSESVGIDTKEDLQNALKIFNSLP
TTP

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=239, Percent_Identity=38.4937238493724, Blast_Score=142, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_HELAH (Q17YX7)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664148.1
- ProteinModelPortal:   Q17YX7
- SMR:   Q17YX7
- STRING:   Q17YX7
- GeneID:   4176133
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0307
- NMPDR:   fig|382638.8.peg.296
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- PhylomeDB:   Q17YX7
- ProtClustDB:   PRK05450
- BioCyc:   HACI382638:HAC_0307-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 27509; Mature: 27509

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIPARLKSSRFENKVLECIFGLPMVVRCAKNASLVDECVVACDDESIMEVCQKFHIKA
CEEECCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VMTSKHHNSGTERCLEAAQLLGLKNDERVLNLQGDEPFLEKEVIAMLLEATKNAPFMATC
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
AKVIDKEKAKNPNLVKVVLDHQNNALYFSRSLIPFLRDFDLKRPTPLLGHIGIYGFHNRE
HHHHHHHHCCCCCEEEEEEECCCCEEEEHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHH
ILEELCSLKPCVLEEIEKLEQLRALYYQKNILVKIVQSESVGIDTKEDLQNALKIFNSLP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHCCC
TTP
CCC
>Mature Secondary Structure
MIIIPARLKSSRFENKVLECIFGLPMVVRCAKNASLVDECVVACDDESIMEVCQKFHIKA
CEEECCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VMTSKHHNSGTERCLEAAQLLGLKNDERVLNLQGDEPFLEKEVIAMLLEATKNAPFMATC
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHH
AKVIDKEKAKNPNLVKVVLDHQNNALYFSRSLIPFLRDFDLKRPTPLLGHIGIYGFHNRE
HHHHHHHHCCCCCEEEEEEECCCCEEEEHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHH
ILEELCSLKPCVLEEIEKLEQLRALYYQKNILVKIVQSESVGIDTKEDLQNALKIFNSLP
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHCCC
TTP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA