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The map label for this gene is ung

Identifier: 109946892

GI number: 109946892

Start: 227646

End: 228347

Strand: Reverse

Name: ung

Synonym: Hac_0276

Alternate gene names: 109946892

Gene position: 228347-227646 (Counterclockwise)

Preceding gene: 109946893

Following gene: 109946891

Centisome position: 14.69

GC content: 41.17

Gene sequence:

>702_bases
ATGAAGCTTTTTGATTACGCTCCCTTAAGCCTAGCTTGGCGGGAGTTTTTACAAAGCGAATTTAAAAAACCTTATTTTTT
AGAAATAGAAAAACGCTACTTAGAAGCCCTAAAAAGCCCTAAAACCATTTTCCCTAAAAGCTCGCATTTGTTTTACGCAC
TCAATCTAACGCCCCCTTGTGCGGTGAAAATCATTCTTTTAGGGCAAGACCCCTACCATTCCATTTACCTAGAAAATAGC
CAAGAATTGCCTGTGGCGATGGGGTTAAGCTTTGGCGTGAATCCAAACGCCCCCATCCCTCCAAGTTTAAGGAATATTTT
TAAAGAATTGCATGCGAATTTAGGCGTGCCTATACCTTGTTGTGGGGATTTGAGTGCATGGGCTAAAAGGGGTATGCTGT
TATTGAATGCCATTTTAAGCGTGGAAAAAAAGCAAGCCGCTTCGCACCAATATATTGGCTGGGAAAATTTTAGCGACAGG
ATATTAGCGCGTCTTTTTGAAACAACCTCCCCTTTAATCGTGGTGTTATTAGGGAAAGTTGCCCAAAAGAAGATCGCTTT
AATTCCCAAAAATAAACACATCATCATCACAGCCCCCCACCCAAGCCCACTGGCTAGAGGGTTTTTAGGGAGTGGGGTTT
TTACAAGCATTCAAAAAGCTTATAGAGAGATTTATCGCAAGGATTTTGATTTTAGTTTGTGA

Upstream 100 bases:

>100_bases
ATGCTAAAAGGCTATACGCCTGATTTTAATTCGCCCACTTGGTATGAAGAATTAGAAGAACGCATGCAAAAAGAGTATTT
AAAACACTACCATGAATTAA

Downstream 100 bases:

>100_bases
TTAATGTTTGAGACAGAACCCCTTAAGAATGGCTTCATTTAAGAGCATTTGTGATAAAATGTCAATTTTTAAATAAAGGG
AAAACATGCCAATTAAAATC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSHLFYALNLTPPCAVKIILLGQDPYHSIYLENS
QELPVAMGLSFGVNPNAPIPPSLRNIFKELHANLGVPIPCCGDLSAWAKRGMLLLNAILSVEKKQAASHQYIGWENFSDR
ILARLFETTSPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLARGFLGSGVFTSIQKAYREIYRKDFDFSL

Sequences:

>Translated_233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSHLFYALNLTPPCAVKIILLGQDPYHSIYLENS
QELPVAMGLSFGVNPNAPIPPSLRNIFKELHANLGVPIPCCGDLSAWAKRGMLLLNAILSVEKKQAASHQYIGWENFSDR
ILARLFETTSPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLARGFLGSGVFTSIQKAYREIYRKDFDFSL
>Mature_233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSHLFYALNLTPPCAVKIILLGQDPYHSIYLENS
QELPVAMGLSFGVNPNAPIPPSLRNIFKELHANLGVPIPCCGDLSAWAKRGMLLLNAILSVEKKQAASHQYIGWENFSDR
ILARLFETTSPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLARGFLGSGVFTSIQKAYREIYRKDFDFSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=223, Percent_Identity=37.6681614349776, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI6224979, Length=223, Percent_Identity=37.6681614349776, Blast_Score=149, Evalue=1e-36,
Organism=Escherichia coli, GI1788934, Length=208, Percent_Identity=39.9038461538462, Blast_Score=154, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17556304, Length=209, Percent_Identity=38.755980861244, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323620, Length=241, Percent_Identity=34.0248962655602, Blast_Score=126, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_HELAH (Q17Z05)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664120.1
- ProteinModelPortal:   Q17Z05
- SMR:   Q17Z05
- STRING:   Q17Z05
- GeneID:   4176683
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0276
- NMPDR:   fig|382638.8.peg.266
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   MLWGNYA
- PhylomeDB:   Q17Z05
- ProtClustDB:   PRK05254
- BioCyc:   HACI382638:HAC_0276-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26297; Mature: 26297

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSHLFYALNLTPPC
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCC
AVKIILLGQDPYHSIYLENSQELPVAMGLSFGVNPNAPIPPSLRNIFKELHANLGVPIPC
CEEEEEECCCCCCEEEECCCCCCCEEECEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKKQAASHQYIGWENFSDRILARLFETTSPLIVVLLGKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
AQKKIALIPKNKHIIITAPHPSPLARGFLGSGVFTSIQKAYREIYRKDFDFSL
HHHHEEEECCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSHLFYALNLTPPC
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCC
AVKIILLGQDPYHSIYLENSQELPVAMGLSFGVNPNAPIPPSLRNIFKELHANLGVPIPC
CEEEEEECCCCCCEEEECCCCCCCEEECEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKKQAASHQYIGWENFSDRILARLFETTSPLIVVLLGKV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
AQKKIALIPKNKHIIITAPHPSPLARGFLGSGVFTSIQKAYREIYRKDFDFSL
HHHHEEEECCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA